TAAR1 — 49 ClinVar variants
All ClinVar germline TAAR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
3 Benign · 2 Likely benign · 44 Uncertain significance
Full TAAR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAAR1 p.Ala168Gly Uncertain significance Single submitter
- TAAR1 p.Ala217Thr Uncertain significance Single submitter
- TAAR1 p.Ala305Val Uncertain significance Single submitter
- TAAR1 p.Arg330Thr Uncertain significance Single submitter
- TAAR1 p.Asn20Ser Uncertain significance Single submitter
- TAAR1 p.Asp226Asn Uncertain significance Single submitter
- TAAR1 p.Cys13Trp Uncertain significance Single submitter
- TAAR1 p.Gln232His Uncertain significance Single submitter
- TAAR1 p.Glu169Lys Uncertain significance Single submitter
- TAAR1 p.Gly167Asp Uncertain significance Single submitter
- TAAR1 p.Gly293Arg Uncertain significance Single submitter
- TAAR1 p.Ile137Thr Uncertain significance Single submitter
- TAAR1 p.Ile241Val Uncertain significance Single submitter
- TAAR1 p.Ile280Val Uncertain significance Single submitter
- TAAR1 p.Ile48Val Uncertain significance Single submitter
- TAAR1 p.Ile98Val Uncertain significance Single submitter
- TAAR1 p.Leu129Pro Uncertain significance Single submitter
- TAAR1 p.Leu337Met Uncertain significance Single submitter
- TAAR1 p.Leu42Met Uncertain significance Single submitter
- TAAR1 p.Lys316Arg Uncertain significance Single submitter
- TAAR1 p.Met237Ile Uncertain significance Single submitter
- TAAR1 p.Met302Thr Uncertain significance Single submitter
- TAAR1 p.Pro301Leu Uncertain significance Single submitter
- TAAR1 p.Pro301Ser Uncertain significance Single submitter
- TAAR1 p.Ser101Asn Uncertain significance Single submitter
- TAAR1 p.Ser190Cys Uncertain significance Single submitter
- TAAR1 p.Ser204Thr Uncertain significance Single submitter
- TAAR1 p.Ser64Phe Uncertain significance Single submitter
- TAAR1 p.Thr197Ile Uncertain significance Single submitter
- TAAR1 p.Thr284Ile Uncertain significance Single submitter
- TAAR1 p.Thr298Ala Uncertain significance Single submitter
- TAAR1 p.Val39Ala Uncertain significance Single submitter
- TAAR1 p.Val39Ile Uncertain significance Single submitter
- TAAR1 p.Val94Ala Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TAAR1 p.Arg23Cys Benign Single submitter
- TAAR1 p.Arg23His Uncertain significance Single submitter
- TAAR1 p.Glu169Ala Uncertain significance Single submitter
- TAAR1 p.His175Pro Uncertain significance Single submitter
- TAAR1 p.Lys245Glu Uncertain significance Single submitter
- TAAR1 p.Met30Ile Uncertain significance Single submitter
- TAAR1 p.Phe195Leu Uncertain significance Single submitter
- TAAR1 p.Thr67Pro Uncertain significance Single submitter
- TAAR1 p.Tyr172Asp Uncertain significance Single submitter
All TAAR1 variants
Benign 3
- p.Arg23Cys Single submitter ⚠
- p.Thr252Ala Single submitter
- p.Thr37= Single submitter
Uncertain significance 44
- p.Ala168Gly Single submitter ⚠
- p.Ala217Thr Single submitter ⚠
- p.Ala249Thr Single submitter
- p.Ala305Val Single submitter ⚠
- p.Arg23His Single submitter ⚠
- p.Arg330Thr Single submitter ⚠
- p.Asn20Ser Single submitter ⚠
- p.Asp226Asn Single submitter ⚠
- p.Cys13Trp Single submitter ⚠
- p.Gln232His Single submitter ⚠
- p.Glu169Ala Single submitter ⚠
- p.Glu169Lys Single submitter ⚠
- p.Gly167Asp Single submitter ⚠
- p.Gly293Arg Single submitter ⚠
- p.His175Pro Single submitter ⚠
- p.Ile137Thr Single submitter ⚠
- p.Ile241Val Single submitter ⚠
- p.Ile269Asn Single submitter
- p.Ile280Val Single submitter ⚠
- p.Ile48Val Single submitter ⚠
- p.Ile98Val Single submitter ⚠
- p.Leu129Pro Single submitter ⚠
- p.Leu337Met Single submitter ⚠
- p.Leu42Met Single submitter ⚠
- p.Lys245Glu Single submitter ⚠
- p.Lys316Arg Single submitter ⚠
- p.Met237Ile Single submitter ⚠
- p.Met302Thr Single submitter ⚠
- p.Met30Ile Single submitter ⚠
- p.Phe195Leu Single submitter ⚠
- p.Pro301Leu Single submitter ⚠
- p.Pro301Ser Single submitter ⚠
- p.Ser101Asn Single submitter ⚠
- p.Ser190Cys Single submitter ⚠
- p.Ser204Thr Single submitter ⚠
- p.Ser64Phe Single submitter ⚠
- p.Thr197Ile Single submitter ⚠
- p.Thr284Ile Single submitter ⚠
- p.Thr298Ala Single submitter ⚠
- p.Thr67Pro Single submitter ⚠
- p.Tyr172Asp Single submitter ⚠
- p.Val39Ala Single submitter ⚠
- p.Val39Ile Single submitter ⚠
- p.Val94Ala Single submitter ⚠