TAAR5 — 57 ClinVar variants
All ClinVar germline TAAR5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
3 Benign · 1 Benign/Likely benign · 6 Likely benign · 47 Uncertain significance
Full TAAR5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAAR5 p.Ala230Val Uncertain significance Single submitter
- TAAR5 p.Ala58Pro Uncertain significance Single submitter
- TAAR5 p.Arg108Leu Uncertain significance Single submitter
- TAAR5 p.Arg26Lys Uncertain significance Single submitter
- TAAR5 p.Asn301Ser Uncertain significance Single submitter
- TAAR5 p.Cys99Arg Uncertain significance Single submitter
- TAAR5 p.Gly103Arg Uncertain significance Single submitter
- TAAR5 p.His124Arg Uncertain significance Single submitter
- TAAR5 p.Ile260Val Uncertain significance Single submitter
- TAAR5 p.Ile33Met Uncertain significance Single submitter
- TAAR5 p.Leu35Met Uncertain significance Single submitter
- TAAR5 p.Leu39Val Uncertain significance Single submitter
- TAAR5 p.Lys198Thr Uncertain significance Single submitter
- TAAR5 p.Lys238Arg Uncertain significance Single submitter
- TAAR5 p.Phe105Leu Uncertain significance Single submitter
- TAAR5 p.Phe123Val Uncertain significance Single submitter
- TAAR5 p.Phe290Cys Uncertain significance Single submitter
- TAAR5 p.Phe296Tyr Uncertain significance Single submitter
- TAAR5 p.Phe307Tyr Uncertain significance Single submitter
- TAAR5 p.Pro143Ser Uncertain significance Single submitter
- TAAR5 p.Pro187Ser Uncertain significance Single submitter
- TAAR5 p.Pro206Leu Uncertain significance Single submitter
- TAAR5 p.Pro25Ser Uncertain significance Single submitter
- TAAR5 p.Pro302Leu Uncertain significance Single submitter
- TAAR5 p.Ser167Leu Uncertain significance Single submitter
- TAAR5 p.Ser180Asn Uncertain significance Single submitter
- TAAR5 p.Ser321Cys Uncertain significance Single submitter
- TAAR5 p.Thr115Ala Uncertain significance Single submitter
- TAAR5 p.Thr115Asn Uncertain significance Single submitter
- TAAR5 p.Thr120Ser Uncertain significance Single submitter
- TAAR5 p.Thr166Ala Uncertain significance Single submitter
- TAAR5 p.Thr227Ala Uncertain significance Single submitter
- TAAR5 p.Thr27Ile Uncertain significance Single submitter
- TAAR5 p.Val224Met Uncertain significance Single submitter
- TAAR5 p.Val53Ile Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- TAAR5 p.Ala40Asp Uncertain significance Single submitter
- TAAR5 p.Arg313Trp Uncertain significance Single submitter
- TAAR5 p.Cys126Phe Uncertain significance Single submitter
- TAAR5 p.Gly259Val Uncertain significance Single submitter
- TAAR5 p.Leu141Phe Uncertain significance Single submitter
- TAAR5 p.Leu320Pro Uncertain significance Single submitter
- TAAR5 p.Leu39Pro Uncertain significance Single submitter
- TAAR5 p.Ser237Ile Uncertain significance Single submitter
- TAAR5 p.Thr120Ile Uncertain significance Single submitter
- TAAR5 p.Thr67Met Likely benign Single submitter
- TAAR5 p.Val49Met Uncertain significance Single submitter
All TAAR5 variants
Benign 3
- p.Arg330Cys Single submitter
- p.Leu140= Single submitter
- p.Thr227= Single submitter
Benign/Likely benign 1
- p.Thr272Met Multiple submitters
Likely benign 6
- p.Ala64Val Single submitter
- p.Arg330Pro Single submitter
- p.Leu119= Single submitter
- p.Leu195Met Single submitter
- p.Phe16= Single submitter
- p.Thr67Met Single submitter ⚠
Uncertain significance 47
- p.Ala230Val Single submitter ⚠
- p.Ala40Asp Single submitter ⚠
- p.Ala58Pro Single submitter ⚠
- p.Arg108Leu Single submitter ⚠
- p.Arg108Pro Single submitter
- p.Arg26Lys Single submitter ⚠
- p.Arg313Trp Single submitter ⚠
- p.Asn301Ser Single submitter ⚠
- p.Asp271Glu Single submitter
- p.Cys126Phe Single submitter ⚠
- p.Cys99Arg Single submitter ⚠
- p.Gly103Arg Single submitter ⚠
- p.Gly259Val Single submitter ⚠
- p.His124Arg Single submitter ⚠
- p.Ile260Val Single submitter ⚠
- p.Ile33Met Single submitter ⚠
- p.Leu141Phe Single submitter ⚠
- p.Leu320Pro Single submitter ⚠
- p.Leu35Met Single submitter ⚠
- p.Leu39Pro Single submitter ⚠
- p.Leu39Val Single submitter ⚠
- p.Lys198Thr Single submitter ⚠
- p.Lys238Arg Single submitter ⚠
- p.Phe105Leu Single submitter ⚠
- p.Phe123Val Single submitter ⚠
- p.Phe290Cys Single submitter ⚠
- p.Phe296Tyr Single submitter ⚠
- p.Phe307Tyr Single submitter ⚠
- p.Pro143Ser Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro206Leu Single submitter ⚠
- p.Pro25Ser Single submitter ⚠
- p.Pro302Leu Single submitter ⚠
- p.Ser167Leu Single submitter ⚠
- p.Ser180Asn Single submitter ⚠
- p.Ser237Ile Single submitter ⚠
- p.Ser321Cys Single submitter ⚠
- p.Thr115Ala Single submitter ⚠
- p.Thr115Asn Single submitter ⚠
- p.Thr120Ile Single submitter ⚠
- p.Thr120Ser Single submitter ⚠
- p.Thr166Ala Single submitter ⚠
- p.Thr227Ala Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Val224Met Single submitter ⚠
- p.Val49Met Single submitter ⚠
- p.Val53Ile Single submitter ⚠