TAB1 — 71 ClinVar variants
All ClinVar germline TAB1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 66 flagged for review →
2 Benign · 2 Likely benign · 67 Uncertain significance
Full TAB1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 66
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAB1 p.Ala225Ser Uncertain significance Single submitter
- TAB1 p.Ala260Val Uncertain significance Single submitter
- TAB1 p.Ala325Thr Uncertain significance Single submitter
- TAB1 p.Ala397Thr Uncertain significance Single submitter
- TAB1 p.Ala503Thr Uncertain significance Single submitter
- TAB1 p.Ala98Val Uncertain significance Single submitter
- TAB1 p.Arg103Gln Uncertain significance Single submitter
- TAB1 p.Arg103Gly Uncertain significance Single submitter
- TAB1 p.Arg104His Uncertain significance Single submitter
- TAB1 p.Arg336His Uncertain significance Single submitter
- TAB1 p.Arg354Gln Uncertain significance Single submitter
- TAB1 p.Arg354Trp Uncertain significance Single submitter
- TAB1 p.Arg35Cys Uncertain significance Single submitter
- TAB1 p.Arg35His Uncertain significance Single submitter
- TAB1 p.Arg463His Uncertain significance Single submitter
- TAB1 p.Arg463Ser Uncertain significance Single submitter
- TAB1 p.Arg465Trp Uncertain significance Single submitter
- TAB1 p.Arg489His Uncertain significance Single submitter
- TAB1 p.Arg75Gln Uncertain significance Single submitter
- TAB1 p.Asn34Ser Uncertain significance Single submitter
- TAB1 p.Asn94Lys Uncertain significance Single submitter
- TAB1 p.Asp196Asn Uncertain significance Single submitter
- TAB1 p.Asp196Gly Uncertain significance Single submitter
- TAB1 p.Asp224Asn Uncertain significance Single submitter
- TAB1 p.Asp40Gly Uncertain significance Single submitter
- TAB1 p.Asp475Gly Uncertain significance Single submitter
- TAB1 p.Gln134Arg Uncertain significance Single submitter
- TAB1 p.Gln237Arg Uncertain significance Single submitter
- TAB1 p.Gln451Lys Uncertain significance Single submitter
- TAB1 p.Glu159Gln Uncertain significance Single submitter
- TAB1 p.Glu238Gly Uncertain significance Single submitter
- TAB1 p.Glu371Lys Uncertain significance Single submitter
- TAB1 p.Gly226Glu Uncertain significance Single submitter
- TAB1 p.Gly476Ser Uncertain significance Single submitter
- TAB1 p.His273Arg Uncertain significance Single submitter
- TAB1 p.Leu152Arg Uncertain significance Single submitter
- TAB1 p.Leu173Pro Uncertain significance Single submitter
- TAB1 p.Leu257Phe Uncertain significance Single submitter
- TAB1 p.Leu434Phe Uncertain significance Single submitter
- TAB1 p.Leu461Phe Uncertain significance Single submitter
- TAB1 p.Phe342Cys Uncertain significance Single submitter
- TAB1 p.Pro270Ser Uncertain significance Single submitter
- TAB1 p.Pro377Leu Uncertain significance Single submitter
- TAB1 p.Ser438Asn Uncertain significance Single submitter
- TAB1 p.Ser469Leu Uncertain significance Single submitter
- TAB1 p.Thr253Arg Uncertain significance Single submitter
- TAB1 p.Thr253Met Uncertain significance Single submitter
- TAB1 p.Thr426Ile Uncertain significance Single submitter
- TAB1 p.Thr433Ile Uncertain significance Single submitter
- TAB1 p.Tyr148Cys Uncertain significance Single submitter
- TAB1 p.Val180Ile Uncertain significance Single submitter
- TAB1 p.Val231Met Uncertain significance Single submitter
- TAB1 p.Val281Leu Uncertain significance Single submitter
- TAB1 p.Val29Ile Uncertain significance Single submitter
- TAB1 p.Val493Met Uncertain significance Single submitter
- TAB1 p.Val500Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TAB1 p.Ala171Val Uncertain significance Single submitter
- TAB1 p.Arg242Trp Uncertain significance Single submitter
- TAB1 p.Arg489Cys Uncertain significance Single submitter
- TAB1 p.Asn364Lys Uncertain significance Single submitter
- TAB1 p.Asp101Asn Uncertain significance Single submitter
- TAB1 p.Asp123Glu Uncertain significance Single submitter
- TAB1 p.Asp458His Uncertain significance Single submitter
- TAB1 p.Gly459Arg Uncertain significance Single submitter
- TAB1 p.Leu155Phe Uncertain significance Single submitter
- TAB1 p.Leu409Ile Uncertain significance Single submitter
All TAB1 variants
Benign 2
- c.325-5C>T Multiple submitters
- p.His355= Multiple submitters
Likely benign 2
- p.Ala98Thr Single submitter
- p.Ser259= Single submitter
Uncertain significance 67
- p.Ala171Val Single submitter ⚠
- p.Ala225Ser Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala325Thr Single submitter ⚠
- p.Ala397Thr Single submitter ⚠
- p.Ala503Thr Single submitter ⚠
- p.Ala98Val Single submitter ⚠
- p.Arg103Gln Single submitter ⚠
- p.Arg103Gly Single submitter ⚠
- p.Arg104His Single submitter ⚠
- p.Arg242Trp Single submitter ⚠
- p.Arg336His Single submitter ⚠
- p.Arg348Cys Single submitter
- p.Arg354Gln Single submitter ⚠
- p.Arg354Trp Single submitter ⚠
- p.Arg35Cys Single submitter ⚠
- p.Arg35His Single submitter ⚠
- p.Arg463His Single submitter ⚠
- p.Arg463Ser Single submitter ⚠
- p.Arg465Trp Single submitter ⚠
- p.Arg489Cys Single submitter ⚠
- p.Arg489His Single submitter ⚠
- p.Arg75Gln Single submitter ⚠
- p.Asn34Ser Single submitter ⚠
- p.Asn364Lys Single submitter ⚠
- p.Asn94Lys Single submitter ⚠
- p.Asp101Asn Single submitter ⚠
- p.Asp123Glu Single submitter ⚠
- p.Asp196Asn Single submitter ⚠
- p.Asp196Gly Single submitter ⚠
- p.Asp224Asn Single submitter ⚠
- p.Asp40Gly Single submitter ⚠
- p.Asp458His Single submitter ⚠
- p.Asp475Gly Single submitter ⚠
- p.Gln134Arg Single submitter ⚠
- p.Gln237Arg Single submitter ⚠
- p.Gln451Lys Single submitter ⚠
- p.Glu159Gln Single submitter ⚠
- p.Glu238Gly Single submitter ⚠
- p.Glu371Lys Single submitter ⚠
- p.Gly226Glu Single submitter ⚠
- p.Gly459Arg Single submitter ⚠
- p.Gly476Ser Single submitter ⚠
- p.His273Arg Single submitter ⚠
- p.Leu152Arg Single submitter ⚠
- p.Leu155Phe Single submitter ⚠
- p.Leu173Pro Single submitter ⚠
- p.Leu257Phe Single submitter ⚠
- p.Leu409Ile Single submitter ⚠
- p.Leu434Phe Single submitter ⚠
- p.Leu461Phe Single submitter ⚠
- p.Phe342Cys Single submitter ⚠
- p.Pro270Ser Single submitter ⚠
- p.Pro377Leu Single submitter ⚠
- p.Ser438Asn Single submitter ⚠
- p.Ser469Leu Single submitter ⚠
- p.Thr253Arg Single submitter ⚠
- p.Thr253Met Single submitter ⚠
- p.Thr426Ile Single submitter ⚠
- p.Thr433Ile Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠
- p.Val180Ile Single submitter ⚠
- p.Val231Met Single submitter ⚠
- p.Val281Leu Single submitter ⚠
- p.Val29Ile Single submitter ⚠
- p.Val493Met Single submitter ⚠
- p.Val500Met Single submitter ⚠