TACR1 — 53 ClinVar variants
All ClinVar germline TACR1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 47 flagged for review →
1 Benign · 4 Likely benign · 48 Uncertain significance
Full TACR1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 47
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 40
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TACR1 p.Ala118Ser Uncertain significance Single submitter
- TACR1 p.Ala162Val Uncertain significance Single submitter
- TACR1 p.Arg311Ser Uncertain significance Single submitter
- TACR1 p.Arg313Leu Uncertain significance Single submitter
- TACR1 p.Arg340Gln Uncertain significance Single submitter
- TACR1 p.Asn23Ser Uncertain significance Single submitter
- TACR1 p.Asn404Ser Uncertain significance Single submitter
- TACR1 p.Cys180Trp Uncertain significance Single submitter
- TACR1 p.Glu183Lys Uncertain significance Single submitter
- TACR1 p.Gly230Arg Uncertain significance Single submitter
- TACR1 p.Gly230Glu Uncertain significance Single submitter
- TACR1 p.Gly329Ser Uncertain significance Single submitter
- TACR1 p.Gly372Val Uncertain significance Single submitter
- TACR1 p.Ile151Leu Uncertain significance Single submitter
- TACR1 p.Ile182Met Uncertain significance Single submitter
- TACR1 p.Ile266Leu Uncertain significance Single submitter
- TACR1 p.Ile326Met Uncertain significance Single submitter
- TACR1 p.Leu102Val Uncertain significance Single submitter
- TACR1 p.Leu308Phe Uncertain significance Single submitter
- TACR1 p.Leu354Met Uncertain significance Single submitter
- TACR1 p.Lys194Arg Uncertain significance Single submitter
- TACR1 p.Lys350Thr Uncertain significance Single submitter
- TACR1 p.Met250Val Uncertain significance Single submitter
- TACR1 p.Pro188Leu Uncertain significance Single submitter
- TACR1 p.Pro369Thr Uncertain significance Single submitter
- TACR1 p.Pro377Thr Uncertain significance Single submitter
- TACR1 p.Ser378Leu Uncertain significance Single submitter
- TACR1 p.Ser390Asn Uncertain significance Single submitter
- TACR1 p.Thr124Met Uncertain significance Single submitter
- TACR1 p.Thr171Arg Uncertain significance Single submitter
- TACR1 p.Thr222Ser Uncertain significance Single submitter
- TACR1 p.Thr344Pro Uncertain significance Single submitter
- TACR1 p.Thr40Ala Uncertain significance Single submitter
- TACR1 p.Tyr92Phe Uncertain significance Single submitter
- TACR1 p.Tyr99Cys Uncertain significance Single submitter
- TACR1 p.Val218Ala Uncertain significance Single submitter
- TACR1 p.Val218Ile Uncertain significance Single submitter
- TACR1 p.Val240Ala Uncertain significance Single submitter
- TACR1 p.Val286Ile Uncertain significance Single submitter
- TACR1 p.Val33Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TACR1 p.Ala77Thr Uncertain significance Single submitter
- TACR1 p.Arg235Cys Uncertain significance Single submitter
- TACR1 p.Arg340Trp Uncertain significance Single submitter
- TACR1 p.Arg353Cys Uncertain significance Single submitter
- TACR1 p.Val179Ala Uncertain significance Single submitter
- TACR1 p.Val43Ala Uncertain significance Single submitter
- TACR1 p.Val43Met Uncertain significance Single submitter
All TACR1 variants
Benign 1
- p.Ser378= No assertion criteria TACR1-related disorder
Likely benign 4
- p.Arg311= Single submitter
- p.Pro188= Single submitter
- p.Phe257= No assertion criteria TACR1-related disorder
- p.Val253Met No assertion criteria TACR1-related disorder
Uncertain significance 48
- p.Ala118Ser Single submitter ⚠
- p.Ala118Thr Single submitter
- p.Ala162Val Single submitter ⚠
- p.Ala77Thr Single submitter ⚠
- p.Arg235Cys Single submitter ⚠
- p.Arg311Ser Single submitter ⚠
- p.Arg313Leu Single submitter ⚠
- p.Arg340Gln Single submitter ⚠
- p.Arg340Trp Single submitter ⚠
- p.Arg353Cys Single submitter ⚠
- p.Asn23Ser Single submitter ⚠
- p.Asn404Ser Single submitter ⚠
- p.Cys180Trp Single submitter ⚠
- p.Glu183Lys Single submitter ⚠
- p.Gly230Arg Single submitter ⚠
- p.Gly230Glu Single submitter ⚠
- p.Gly329Ser Single submitter ⚠
- p.Gly372Val Single submitter ⚠
- p.Ile151Leu Single submitter ⚠
- p.Ile182Met Single submitter ⚠
- p.Ile266Leu Single submitter ⚠
- p.Ile326Met Single submitter ⚠
- p.Leu102Val Single submitter ⚠
- p.Leu308Phe Single submitter ⚠
- p.Leu354Met Single submitter ⚠
- p.Lys194Arg Single submitter ⚠
- p.Lys350Thr Single submitter ⚠
- p.Met250Val Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro369Thr Single submitter ⚠
- p.Pro377Thr Single submitter ⚠
- p.Ser378Leu Single submitter ⚠
- p.Ser390Asn Single submitter ⚠
- p.Thr124Met Single submitter ⚠
- p.Thr171Arg Single submitter ⚠
- p.Thr222Ser Single submitter ⚠
- p.Thr344Pro Single submitter ⚠
- p.Thr40Ala Single submitter ⚠
- p.Tyr92Phe Single submitter ⚠
- p.Tyr99Cys Single submitter ⚠
- p.Val179Ala Single submitter ⚠
- p.Val218Ala Single submitter ⚠
- p.Val218Ile Single submitter ⚠
- p.Val240Ala Single submitter ⚠
- p.Val286Ile Single submitter ⚠
- p.Val33Ile Single submitter ⚠
- p.Val43Ala Single submitter ⚠
- p.Val43Met Single submitter ⚠