TACR2 — 60 ClinVar variants
All ClinVar germline TACR2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
5 Benign · 4 Likely benign · 51 Uncertain significance
Full TACR2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TACR2 p.Ala116Thr Uncertain significance Single submitter
- TACR2 p.Ala161Ser Uncertain significance Single submitter
- TACR2 p.Ala237Gly Uncertain significance Single submitter
- TACR2 p.Ala373Val Uncertain significance Single submitter
- TACR2 p.Ala37Thr Uncertain significance Single submitter
- TACR2 p.Ala84Ser Uncertain significance Single submitter
- TACR2 p.Ala84Thr Uncertain significance Single submitter
- TACR2 p.Arg323Cys Uncertain significance Single submitter
- TACR2 p.Arg65His Uncertain significance Single submitter
- TACR2 p.Asn74Ser Uncertain significance Single submitter
- TACR2 p.Asn86Asp Uncertain significance Single submitter
- TACR2 p.Asn90Ser Uncertain significance Single submitter
- TACR2 p.Gln233Arg Uncertain significance Single submitter
- TACR2 p.Gln233Leu Uncertain significance Single submitter
- TACR2 p.Gly22Ser Uncertain significance Single submitter
- TACR2 p.Gly381Ala Uncertain significance Single submitter
- TACR2 p.His352Arg Uncertain significance Single submitter
- TACR2 p.Ile114Thr Uncertain significance Single submitter
- TACR2 p.Ile155Val Uncertain significance Single submitter
- TACR2 p.Ile53Val Uncertain significance Single submitter
- TACR2 p.Ile58Asn Uncertain significance Single submitter
- TACR2 p.Leu222Val Uncertain significance Single submitter
- TACR2 p.Leu80Arg Uncertain significance Single submitter
- TACR2 p.Lys250Gln Uncertain significance Single submitter
- TACR2 p.Met117Ile Uncertain significance Single submitter
- TACR2 p.Met133Val Uncertain significance Single submitter
- TACR2 p.Met301Thr Uncertain significance Single submitter
- TACR2 p.Pro330Ser Uncertain significance Single submitter
- TACR2 p.Ser189Gly Uncertain significance Single submitter
- TACR2 p.Ser18Asn Uncertain significance Single submitter
- TACR2 p.Ser30Arg Uncertain significance Single submitter
- TACR2 p.Ser370Arg Uncertain significance Single submitter
- TACR2 p.Thr20Ile Uncertain significance Single submitter
- TACR2 p.Thr341Arg Uncertain significance Single submitter
- TACR2 p.Thr341Met Uncertain significance Single submitter
- TACR2 p.Thr394Asn Uncertain significance Single submitter
- TACR2 p.Trp156Cys Uncertain significance Single submitter
- TACR2 p.Trp383Arg Uncertain significance Single submitter
- TACR2 p.Tyr197Cys Uncertain significance Single submitter
- TACR2 p.Tyr93Cys Uncertain significance Single submitter
- TACR2 p.Val136Ile Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TACR2 p.Ala87Asp Uncertain significance Single submitter
- TACR2 p.Arg142Trp Uncertain significance Single submitter
- TACR2 p.Arg315Cys Uncertain significance Single submitter
- TACR2 p.Arg65Cys Uncertain significance Single submitter
- TACR2 p.Cys325Tyr Uncertain significance Single submitter
- TACR2 p.Gly191Asp Uncertain significance Single submitter
- TACR2 p.Leu254Pro Uncertain significance Single submitter
- TACR2 p.Phe322Leu Uncertain significance Single submitter
- TACR2 p.Pro186Ser Uncertain significance Single submitter
All TACR2 variants
Benign 5
- p.Arg323His Multiple submitters
- p.Asp5Gly Multiple submitters
- p.Thr251Ala Multiple submitters
- c.392+8G>A Single submitter
- p.Pro376= Single submitter
Likely benign 4
- p.Ala211Val Single submitter
- p.Leu257Val Single submitter
- p.Thr193Met Single submitter
- p.Thr341= Single submitter
Uncertain significance 51
- p.Ala116Thr Single submitter ⚠
- p.Ala161Ser Single submitter ⚠
- p.Ala237Gly Single submitter ⚠
- p.Ala373Val Single submitter ⚠
- p.Ala37Thr Single submitter ⚠
- p.Ala84Ser Single submitter ⚠
- p.Ala84Thr Single submitter ⚠
- p.Ala87Asp Single submitter ⚠
- p.Arg142Trp Single submitter ⚠
- p.Arg315Cys Single submitter ⚠
- p.Arg323Cys Single submitter ⚠
- p.Arg65Cys Single submitter ⚠
- p.Arg65His Single submitter ⚠
- p.Asn74Ser Single submitter ⚠
- p.Asn86Asp Single submitter ⚠
- p.Asn90Ser Single submitter ⚠
- p.Cys325Tyr Single submitter ⚠
- p.Gln233Arg Single submitter ⚠
- p.Gln233Leu Single submitter ⚠
- p.Gly191Asp Single submitter ⚠
- p.Gly22Ser Single submitter ⚠
- p.Gly381Ala Single submitter ⚠
- p.His352Arg Single submitter ⚠
- p.Ile114Thr Single submitter ⚠
- p.Ile155Val Single submitter ⚠
- p.Ile53Val Single submitter ⚠
- p.Ile58Asn Single submitter ⚠
- p.Leu222Val Single submitter ⚠
- p.Leu254Arg Single submitter
- p.Leu254Pro Single submitter ⚠
- p.Leu80Arg Single submitter ⚠
- p.Lys250Gln Single submitter ⚠
- p.Met117Ile Single submitter ⚠
- p.Met133Val Single submitter ⚠
- p.Met301Thr Single submitter ⚠
- p.Phe322Leu Single submitter ⚠
- p.Pro186Ser Single submitter ⚠
- p.Pro330Ser Single submitter ⚠
- p.Ser189Gly Single submitter ⚠
- p.Ser18Asn Single submitter ⚠
- p.Ser30Arg Single submitter ⚠
- p.Ser370Arg Single submitter ⚠
- p.Thr20Ile Single submitter ⚠
- p.Thr341Arg Single submitter ⚠
- p.Thr341Met Single submitter ⚠
- p.Thr394Asn Single submitter ⚠
- p.Trp156Cys Single submitter ⚠
- p.Trp383Arg Single submitter ⚠
- p.Tyr197Cys Single submitter ⚠
- p.Tyr93Cys Single submitter ⚠
- p.Val136Ile Single submitter ⚠