TADA2A — 53 ClinVar variants
All ClinVar germline TADA2A variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 50 flagged for review →
53 Uncertain significance
Full TADA2A gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 50
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TADA2A p.Ala183Val Uncertain significance Single submitter
- TADA2A p.Ala202Val Uncertain significance Single submitter
- TADA2A p.Ala82Thr Uncertain significance Single submitter
- TADA2A p.Arg163Gln Uncertain significance Single submitter
- TADA2A p.Arg241Gln Uncertain significance Single submitter
- TADA2A p.Arg241Trp Uncertain significance Single submitter
- TADA2A p.Arg242Gln Uncertain significance Single submitter
- TADA2A p.Arg301Lys Uncertain significance Single submitter
- TADA2A p.Arg314Cys Uncertain significance Single submitter
- TADA2A p.Arg317His Uncertain significance Single submitter
- TADA2A p.Arg338His Uncertain significance Single submitter
- TADA2A p.Arg339Gln Uncertain significance Single submitter
- TADA2A p.Arg3His Uncertain significance Single submitter
- TADA2A p.Asn296Lys Uncertain significance Single submitter
- TADA2A p.Asn9Ser Uncertain significance Single submitter
- TADA2A p.Asp195Glu Uncertain significance Single submitter
- TADA2A p.Asp304Asn Uncertain significance Single submitter
- TADA2A p.Gln219His Uncertain significance Single submitter
- TADA2A p.Gln248Arg Uncertain significance Single submitter
- TADA2A p.Gln44Lys Uncertain significance Single submitter
- TADA2A p.Glu136Lys Uncertain significance Single submitter
- TADA2A p.Glu382Gln Uncertain significance Single submitter
- TADA2A p.Gly167Arg Uncertain significance Single submitter
- TADA2A p.Gly91Val Uncertain significance Single submitter
- TADA2A p.Ile144Val Uncertain significance Single submitter
- TADA2A p.Leu376Pro Uncertain significance Single submitter
- TADA2A p.Lys132Arg Uncertain significance Single submitter
- TADA2A p.Lys14Glu Uncertain significance Single submitter
- TADA2A p.Lys268Arg Uncertain significance Single submitter
- TADA2A p.Lys398Thr Uncertain significance Single submitter
- TADA2A p.Met254Val Uncertain significance Single submitter
- TADA2A p.Met25Val Uncertain significance Single submitter
- TADA2A p.Phe40Ser Uncertain significance Single submitter
- TADA2A p.Pro11Arg Uncertain significance Single submitter
- TADA2A p.Pro73Arg Uncertain significance Single submitter
- TADA2A p.Ser159Ala Uncertain significance Single submitter
- TADA2A p.Ser355Leu Uncertain significance Single submitter
- TADA2A p.Thr368Ser Uncertain significance Single submitter
- TADA2A p.Thr441Ser Uncertain significance Single submitter
- TADA2A p.Tyr211Cys Uncertain significance Single submitter
- TADA2A p.Tyr23Cys Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TADA2A p.Asp158Glu Uncertain significance Single submitter
- TADA2A p.Asp186Glu Uncertain significance Single submitter
- TADA2A p.Cys90Arg Uncertain significance Single submitter
- TADA2A p.Glu217Asp Uncertain significance Single submitter
- TADA2A p.Leu320Pro Uncertain significance Single submitter
- TADA2A p.Lys107Glu Uncertain significance Single submitter
- TADA2A p.Met169Val Uncertain significance Single submitter
- TADA2A p.Phe146Leu Uncertain significance Single submitter
- TADA2A p.Val87Met Uncertain significance Single submitter
All TADA2A variants
Uncertain significance 53
- p.Ala183Val Single submitter ⚠
- p.Ala202Val Single submitter ⚠
- p.Ala82Thr Single submitter ⚠
- p.Arg163Gln Single submitter ⚠
- p.Arg241Gln Single submitter ⚠
- p.Arg241Trp Single submitter ⚠
- p.Arg242Gln Single submitter ⚠
- p.Arg301Lys Single submitter ⚠
- p.Arg314Cys Single submitter ⚠
- p.Arg317His Single submitter ⚠
- p.Arg338His Single submitter ⚠
- p.Arg339Gln Single submitter ⚠
- p.Arg3His Single submitter ⚠
- p.Asn296Lys Single submitter ⚠
- p.Asn9Ser Single submitter ⚠
- p.Asp158Glu Single submitter ⚠
- p.Asp186Glu Single submitter ⚠
- p.Asp195Glu Single submitter ⚠
- p.Asp209Gly Single submitter
- p.Asp227His Single submitter
- p.Asp304Asn Single submitter ⚠
- p.Cys90Arg Single submitter ⚠
- p.Gln219His Single submitter ⚠
- p.Gln248Arg Single submitter ⚠
- p.Gln44Lys Single submitter ⚠
- p.Glu136Lys Single submitter ⚠
- p.Glu217Asp Single submitter ⚠
- p.Glu382Gln Single submitter ⚠
- p.Gly167Arg Single submitter ⚠
- p.Gly91Val Single submitter ⚠
- p.Ile144Val Single submitter ⚠
- p.Leu320Pro Single submitter ⚠
- p.Leu376Pro Single submitter ⚠
- p.Lys107Glu Single submitter ⚠
- p.Lys132Arg Single submitter ⚠
- p.Lys14Glu Single submitter ⚠
- p.Lys268Arg Single submitter ⚠
- p.Lys398Thr Single submitter ⚠
- p.Met169Val Single submitter ⚠
- p.Met254Val Single submitter ⚠
- p.Met25Val Single submitter ⚠
- p.Phe146Leu Single submitter ⚠
- p.Phe40Ser Single submitter ⚠
- p.Pro11Arg Single submitter ⚠
- p.Pro73Arg Single submitter ⚠
- p.Ser159Ala Single submitter ⚠
- p.Ser197Leu Single submitter
- p.Ser355Leu Single submitter ⚠
- p.Thr368Ser Single submitter ⚠
- p.Thr441Ser Single submitter ⚠
- p.Tyr211Cys Single submitter ⚠
- p.Tyr23Cys Single submitter ⚠
- p.Val87Met Single submitter ⚠