TAF15 — 202 ClinVar variants
All ClinVar germline TAF15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
4 Conflicting · 30 Benign · 7 Benign/Likely benign · 57 Likely benign · 104 Uncertain significance
Full TAF15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 36
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
TAF15 p.Arg395Gln
Uncertain significance
Multiple submitters
TAF15-related disorder
-
TAF15 p.Ile312Val
Uncertain significance
Multiple submitters
TAF15-related disorder
-
TAF15 p.Ala102Val
Uncertain significance
Single submitter
extraskeletal myxoid chondrosarcoma
- TAF15 p.Ala224Ser Uncertain significance Single submitter
-
TAF15 p.Arg408Cys
Uncertain significance
Single submitter
TAF15-related disorder
- TAF15 p.Arg475Pro Uncertain significance Single submitter
- TAF15 p.Arg528Gln Uncertain significance Single submitter
- TAF15 p.Arg580Lys Uncertain significance Single submitter
- TAF15 p.Asn311Ser Uncertain significance Single submitter
- TAF15 p.Asn589Ser Uncertain significance Single submitter
- TAF15 p.Asp123Asn Uncertain significance Single submitter
- TAF15 p.Asp130Ala Uncertain significance Single submitter
- TAF15 p.Gln146Lys Uncertain significance Single submitter
- TAF15 p.Gln152Glu Uncertain significance Single submitter
- TAF15 p.Gln73Pro Uncertain significance Single submitter
- TAF15 p.Gln75Glu Uncertain significance Single submitter
- TAF15 p.Gln90Arg Uncertain significance Single submitter
- TAF15 p.Gly127Ser Uncertain significance Single submitter
- TAF15 p.Gly329Ala Uncertain significance Single submitter
- TAF15 p.Gly416Ser Uncertain significance Single submitter
-
TAF15 p.Gly530Ser
Uncertain significance
Single submitter
TAF15-related disorder
- TAF15 p.Gly556Ser Uncertain significance Single submitter
- TAF15 p.His139Arg Uncertain significance Single submitter
- TAF15 p.His159Tyr Uncertain significance Single submitter
- TAF15 p.His309Gln Uncertain significance Single submitter
- TAF15 p.Lys261Met Uncertain significance Single submitter
- TAF15 p.Met577Ile Uncertain significance Single submitter
- TAF15 p.Pro384Arg Uncertain significance Single submitter
- TAF15 p.Ser104Ala Uncertain significance Single submitter
- TAF15 p.Ser2Leu Uncertain significance Single submitter
- TAF15 p.Ser51Gly Uncertain significance Single submitter
- TAF15 p.Ser6Gly Uncertain significance Single submitter
- TAF15 p.Ser95Leu Uncertain significance Single submitter
- TAF15 p.Thr160Pro Uncertain significance Single submitter
- TAF15 p.Thr41Ala Uncertain significance Single submitter
-
TAF15 p.Arg337Cys
Uncertain significance
No assertion criteria
TAF15-related disorder
Predictors split 56
The independent predictors disagree with each other — read with care.
-
TAF15 p.Arg483Gln
Uncertain significance
Multiple submitters
TAF15-related disorder
- TAF15 p.Arg483Gly Uncertain significance Multiple submitters
-
TAF15 p.Arg545Gln
Uncertain significance
Multiple submitters
TAF15-related disorder
-
TAF15 p.Gly473Glu
Uncertain significance
Multiple submitters
TAF15-related disorder
- TAF15 p.Tyr20Cys Uncertain significance Multiple submitters
- TAF15 p.Tyr455Cys Likely benign Multiple submitters
- TAF15 p.Arg475Gln Uncertain significance Single submitter
-
TAF15 p.Arg512Gln
Uncertain significance
Single submitter
TAF15-related disorder
- TAF15 p.Arg528Trp Uncertain significance Single submitter
- TAF15 p.Arg535Gly Uncertain significance Single submitter
- TAF15 p.Arg535His Uncertain significance Single submitter
- TAF15 p.Asn380Tyr Uncertain significance Single submitter
- TAF15 p.Asp229Glu Uncertain significance Single submitter
- TAF15 p.Asp440Asn Uncertain significance Single submitter
- TAF15 p.Asp440Val Uncertain significance Single submitter
- TAF15 p.Gly200Arg Uncertain significance Single submitter
- TAF15 p.Gly338Arg Uncertain significance Single submitter
- TAF15 p.Gly366Arg Uncertain significance Single submitter
- TAF15 p.Gly391Glu Uncertain significance Single submitter
- TAF15 p.Gly391Val Uncertain significance Single submitter
- TAF15 p.Gly439Arg Uncertain significance Single submitter
- TAF15 p.Gly453Ser Likely benign Single submitter
- TAF15 p.Gly453Val Uncertain significance Single submitter
- TAF15 p.Gly462Ser Uncertain significance Single submitter
- TAF15 p.Gly464Val Uncertain significance Single submitter
- TAF15 p.Gly476Arg Uncertain significance Single submitter
- TAF15 p.Gly500Ser Uncertain significance Single submitter
- TAF15 p.Gly523Arg Uncertain significance Single submitter
- TAF15 p.Gly529Arg Uncertain significance Single submitter
- TAF15 p.Gly536Ala Uncertain significance Single submitter
- TAF15 p.Gly551Arg Uncertain significance Single submitter
-
TAF15 p.Gly556Asp
Uncertain significance
Single submitter
TAF15-related disorder
- TAF15 p.Ile300Val Uncertain significance Single submitter
- TAF15 p.Lys281Glu Uncertain significance Single submitter
- TAF15 p.Met368Thr Uncertain significance Single submitter
- TAF15 p.Phe346Ser Uncertain significance Single submitter
- TAF15 p.Ser442Asn Uncertain significance Single submitter
- TAF15 p.Ser442Cys Uncertain significance Single submitter
- TAF15 p.Ser539Ile Uncertain significance Single submitter
- TAF15 p.Ser76Ile Uncertain significance Single submitter
- TAF15 p.Thr41Met Uncertain significance Single submitter
- TAF15 p.Tyr105Cys Uncertain significance Single submitter
- TAF15 p.Tyr122Cys Likely benign Single submitter
- TAF15 p.Tyr149Cys Uncertain significance Single submitter
- TAF15 p.Tyr177Cys Uncertain significance Single submitter
- TAF15 p.Tyr35Phe Uncertain significance Single submitter
- TAF15 p.Tyr455Asn Uncertain significance Single submitter
- TAF15 p.Tyr463Cys Conflicting Single submitter
- TAF15 p.Tyr471Cys Uncertain significance Single submitter
- TAF15 p.Tyr515Asp Uncertain significance Single submitter
- TAF15 p.Tyr522His Uncertain significance Single submitter
- TAF15 p.Tyr549Cys Uncertain significance Single submitter
- TAF15 p.Tyr83Cys Uncertain significance Single submitter
-
TAF15 p.Gly69Cys
Likely benign
No assertion criteria
TAF15-related disorder
-
TAF15 p.Tyr110Cys
Uncertain significance
No assertion criteria
TAF15-related disorder
-
TAF15 p.Tyr486Cys
Uncertain significance
No assertion criteria
TAF15-related disorder
All TAF15 variants
Conflicting classifications of pathogenicity 4
- p.454_461GYGGDRGG[3] Single submitter TAF15-related disorder
- p.454GYGGDRGG[5] Single submitter amyotrophic lateral sclerosis
- p.Arg459_Gly460insSerGlyGlyGlyTyrGlyGlyAspArg Single submitter
- p.Tyr463Cys Single submitter ⚠
Benign 30
- c.291-84G>A Multiple submitters
- c.485-107G>A Multiple submitters
- c.606-147C>T Multiple submitters
- c.641-289G>A Multiple submitters
- c.8-260A>G Multiple submitters
- p.Arg388His Multiple submitters
- p.Asp292= Multiple submitters
- p.Asp482= Multiple submitters
- p.Gly429= Multiple submitters
- p.Gly444= Multiple submitters
- p.Gly542Ser Multiple submitters
- p.Tyr508= Multiple submitters
- c.1088+60A>G Single submitter
- c.290+105del Single submitter
- c.291-142A>G Single submitter
- c.291-278dup Single submitter
- c.48-210C>A Single submitter
- c.485-178G>C Single submitter
- c.605+57dup Single submitter
- c.673+56del Single submitter
- c.673+56dup Single submitter
- c.783+142G>C Single submitter
- c.783+152T>A Single submitter
- c.783+320G>A Single submitter
- c.913+48dup Single submitter
- c.914-216G>A Single submitter
- p.442SGGGYGGDR[1] Single submitter
- p.Arg562= Single submitter
- p.Asp449= Single submitter
- p.Gly448= Single submitter
Benign/Likely benign 7
- c.485-4G>C Multiple submitters
- p.454GYGGDRGG[3] Multiple submitters
- p.492GGYGGDR[4] Multiple submitters
- p.492GGYGGDR[6] Multiple submitters
- p.Gly242= Multiple submitters
- p.Gly453= Multiple submitters
- p.Pro220= Multiple submitters
Likely benign 57
- c.1178-29G>A Multiple submitters
- c.641-29T>C Multiple submitters
- c.641-50T>C Multiple submitters
- c.7+288G>A Multiple submitters
- c.913+37G>T Multiple submitters
- p.Gly468= Multiple submitters
- p.Gly52Ser Multiple submitters
- p.Gly555= Multiple submitters
- p.Tyr455Cys Multiple submitters ⚠
- c.1006+3A>G Single submitter
- c.1089-25G>A Single submitter
- c.185-16C>T Single submitter
- c.290+106A>T Single submitter
- c.290+157G>A Single submitter
- c.291-278del Single submitter
- c.606-321_606-317del Single submitter
- c.673+257C>A Single submitter
- c.674-294C>A Single submitter
- c.8-17C>A Single submitter
- c.8-202A>G Single submitter
- p.442SGGGYGGDR[3] Single submitter
- p.Arg467= Single submitter
- p.Arg526_Ser527insGlyGlyTyrGlyGlyAspArg Single submitter TAF15-related disorder
- p.Asp489= Single submitter
- p.Asp497= Single submitter
- p.Gly453Ser Single submitter ⚠
- p.Gly457= Single submitter
- p.Gly464= Single submitter
- p.Gly465= Single submitter
- p.Gly469= Single submitter
- p.Gly493= Single submitter
- p.Gly495= Single submitter
- p.Gly500= Single submitter
- p.Gly521= Single submitter
- p.Gly556= Single submitter
- p.Ser438= Single submitter
- p.Ser438Gly Single submitter
- p.Tyr122Cys Single submitter ⚠
- p.Tyr515= Single submitter
- c.484+6A>G No assertion criteria TAF15-related disorder
- c.673+6G>C No assertion criteria TAF15-related disorder
- c.913+10A>T No assertion criteria TAF15-related disorder
- p.479YGGDRGG[1] No assertion criteria TAF15-related disorder
- p.Asp440= No assertion criteria TAF15-related disorder
- p.Cys365= No assertion criteria TAF15-related disorder
- p.Gly416= No assertion criteria TAF15-related disorder
- p.Gly424_Ser432del No assertion criteria TAF15-related disorder
- p.Gly456= No assertion criteria TAF15-related disorder
- p.Gly460= No assertion criteria TAF15-related disorder
- p.Gly461= No assertion criteria TAF15-related disorder
- p.Gly476= No assertion criteria TAF15-related disorder
- p.Gly477= No assertion criteria TAF15-related disorder
- p.Gly491= No assertion criteria TAF15-related disorder
- p.Gly69Cys No assertion criteria TAF15-related disorder ⚠
- p.His215Gln No assertion criteria TAF15-related disorder
- p.Thr41= No assertion criteria TAF15-related disorder
- p.Tyr427_Gly435del No assertion criteria TAF15-related disorder
Uncertain significance 104
- p.Arg395Gln Multiple submitters TAF15-related disorder ⚠
- p.Arg483Gln Multiple submitters TAF15-related disorder ⚠
- p.Arg483Gly Multiple submitters ⚠
- p.Arg545Gln Multiple submitters TAF15-related disorder ⚠
- p.Gly473Glu Multiple submitters TAF15-related disorder ⚠
- p.Ile312Val Multiple submitters TAF15-related disorder ⚠
- p.Ser432_Arg459del Multiple submitters amyotrophic lateral sclerosis
- p.Ser539_Gly565del Multiple submitters TAF15-related disorder
- p.Tyr20Cys Multiple submitters ⚠
- c.1401_1402ins1351_1377 Single submitter amyotrophic lateral sclerosis
- p.478GYGGDRGGYGGDRGG[1] Single submitter
- p.Ala102Val Single submitter extraskeletal myxoid chondrosarcoma ⚠
- p.Ala224Ser Single submitter ⚠
- p.Arg408Cys Single submitter TAF15-related disorder ⚠
- p.Arg459_Gly460insSer Single submitter amyotrophic lateral sclerosis
- p.Arg475Gln Single submitter ⚠
- p.Arg475Pro Single submitter ⚠
- p.Arg512Gln Single submitter TAF15-related disorder ⚠
- p.Arg526_Ser527insGlyGlyTyrGlyGlyAspArgGlyGlyTyrGlyGlyAspArg Single submitter TAF15-related disorder
- p.Arg528Gln Single submitter ⚠
- p.Arg528Trp Single submitter ⚠
- p.Arg535Gly Single submitter ⚠
- p.Arg535His Single submitter ⚠
- p.Arg580Lys Single submitter ⚠
- p.Asn311Ser Single submitter ⚠
- p.Asn380Tyr Single submitter ⚠
- p.Asn589Ser Single submitter ⚠
- p.Asp123Asn Single submitter ⚠
- p.Asp130Ala Single submitter ⚠
- p.Asp229Glu Single submitter ⚠
- p.Asp440Asn Single submitter ⚠
- p.Asp440Val Single submitter ⚠
- p.Gln146Lys Single submitter ⚠
- p.Gln152Glu Single submitter ⚠
- p.Gln48Arg Single submitter
- p.Gln73Pro Single submitter ⚠
- p.Gln75Glu Single submitter ⚠
- p.Gln90Arg Single submitter ⚠
- p.Gly127Ser Single submitter ⚠
- p.Gly200Arg Single submitter ⚠
- p.Gly329Ala Single submitter ⚠
- p.Gly338Arg Single submitter ⚠
- p.Gly339Val Single submitter
- p.Gly366Arg Single submitter ⚠
- p.Gly391Glu Single submitter ⚠
- p.Gly391Val Single submitter ⚠
- p.Gly416Ser Single submitter ⚠
- p.Gly424_Ser432dup Single submitter
- p.Gly439Arg Single submitter ⚠
- p.Gly444Asp Single submitter
- p.Gly447Ser Single submitter
- p.Gly453Val Single submitter ⚠
- p.Gly462Ser Single submitter ⚠
- p.Gly464Val Single submitter ⚠
- p.Gly476Arg Single submitter ⚠
- p.Gly500Ser Single submitter ⚠
- p.Gly507_Tyr508insGlyTyrGlyGlyAspArgGlyGlyTyrGlyGlyAspArgGlyGly Single submitter
- p.Gly514Asp Single submitter
- p.Gly523Arg Single submitter ⚠
- p.Gly529Arg Single submitter ⚠
- p.Gly529Trp Single submitter
- p.Gly530Ser Single submitter TAF15-related disorder ⚠
- p.Gly536Ala Single submitter ⚠
- p.Gly551Arg Single submitter ⚠
- p.Gly556Asp Single submitter TAF15-related disorder ⚠
- p.Gly556Ser Single submitter ⚠
- p.His139Arg Single submitter ⚠
- p.His159Tyr Single submitter ⚠
- p.His309Gln Single submitter ⚠
- p.Ile300Val Single submitter ⚠
- p.Lys261Met Single submitter ⚠
- p.Lys281Glu Single submitter ⚠
- p.Met368Thr Single submitter ⚠
- p.Met577Ile Single submitter ⚠
- p.Phe346Ser Single submitter ⚠
- p.Pro384Arg Single submitter ⚠
- p.Ser104Ala Single submitter ⚠
- p.Ser2Leu Single submitter ⚠
- p.Ser442Asn Single submitter ⚠
- p.Ser442Cys Single submitter ⚠
- p.Ser51Gly Single submitter ⚠
- p.Ser539Ile Single submitter ⚠
- p.Ser6Gly Single submitter ⚠
- p.Ser76Ile Single submitter ⚠
- p.Ser95Leu Single submitter ⚠
- p.Thr160Pro Single submitter ⚠
- p.Thr41Ala Single submitter ⚠
- p.Thr41Met Single submitter ⚠
- p.Tyr105Cys Single submitter ⚠
- p.Tyr149Cys Single submitter ⚠
- p.Tyr177Cys Single submitter ⚠
- p.Tyr35Phe Single submitter ⚠
- p.Tyr455Asn Single submitter ⚠
- p.Tyr471Cys Single submitter ⚠
- p.Tyr515Asp Single submitter ⚠
- p.Tyr522His Single submitter ⚠
- p.Tyr549Cys Single submitter ⚠
- p.Tyr83Cys Single submitter ⚠
- p.454GYGGDRGG[2] No assertion criteria TAF15-related disorder
- p.557GYGGDRGG[1] No assertion criteria TAF15-related disorder
- p.Arg337Cys No assertion criteria TAF15-related disorder ⚠
- p.Gly485_Tyr486insGlyTyrGlyGlyAspArgGlyGly No assertion criteria TAF15-related disorder
- p.Tyr110Cys No assertion criteria TAF15-related disorder ⚠
- p.Tyr486Cys No assertion criteria TAF15-related disorder ⚠