TAF1B — 74 ClinVar variants
All ClinVar germline TAF1B variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 67 flagged for review →
3 Likely benign · 71 Uncertain significance
Full TAF1B gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 67
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 60
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAF1B p.Ala164Val Uncertain significance Single submitter
- TAF1B p.Ala421Thr Uncertain significance Single submitter
- TAF1B p.Arg111His Uncertain significance Single submitter
- TAF1B p.Arg12Ser Uncertain significance Single submitter
- TAF1B p.Arg201Gln Uncertain significance Single submitter
- TAF1B p.Asn46Ser Uncertain significance Single submitter
- TAF1B p.Asn66Thr Uncertain significance Single submitter
- TAF1B p.Asp103Asn Uncertain significance Single submitter
- TAF1B p.Asp103Tyr Uncertain significance Single submitter
- TAF1B p.Asp439Asn Uncertain significance Single submitter
- TAF1B p.Asp485Gly Uncertain significance Single submitter
- TAF1B p.Asp485Val Uncertain significance Single submitter
- TAF1B p.Asp73Asn Uncertain significance Single submitter
- TAF1B p.Gln183Leu Uncertain significance Single submitter
- TAF1B p.Gln503Arg Uncertain significance Single submitter
- TAF1B p.Glu185Gly Uncertain significance Single submitter
- TAF1B p.Glu275Lys Uncertain significance Single submitter
- TAF1B p.Glu419Asp Uncertain significance Single submitter
- TAF1B p.Glu419Lys Uncertain significance Single submitter
- TAF1B p.Glu500Gln Uncertain significance Single submitter
- TAF1B p.Gly205Arg Uncertain significance Single submitter
- TAF1B p.Gly22Cys Uncertain significance Single submitter
- TAF1B p.Gly502Val Uncertain significance Single submitter
- TAF1B p.His141Gln Uncertain significance Single submitter
- TAF1B p.His251Arg Uncertain significance Single submitter
- TAF1B p.His303Arg Uncertain significance Single submitter
- TAF1B p.His327Leu Uncertain significance Single submitter
- TAF1B p.Ile229Val Uncertain significance Single submitter
- TAF1B p.Ile246Val Uncertain significance Single submitter
- TAF1B p.Ile268Thr Uncertain significance Single submitter
- TAF1B p.Ile306Met Uncertain significance Single submitter
- TAF1B p.Ile306Thr Uncertain significance Single submitter
- TAF1B p.Ile345Val Uncertain significance Single submitter
- TAF1B p.Ile362Thr Uncertain significance Single submitter
- TAF1B p.Lys392Glu Uncertain significance Single submitter
- TAF1B p.Lys470Asn Uncertain significance Single submitter
- TAF1B p.Lys501Arg Uncertain significance Single submitter
- TAF1B p.Lys576Glu Uncertain significance Single submitter
- TAF1B p.Lys579Gln Uncertain significance Single submitter
- TAF1B p.Pro157Leu Uncertain significance Single submitter
- TAF1B p.Pro158Ala Uncertain significance Single submitter
- TAF1B p.Pro175Arg Uncertain significance Single submitter
- TAF1B p.Pro98Gln Uncertain significance Single submitter
- TAF1B p.Ser199Ala Uncertain significance Single submitter
- TAF1B p.Ser323Arg Uncertain significance Single submitter
- TAF1B p.Ser429Thr Uncertain significance Single submitter
- TAF1B p.Ser471Asn Uncertain significance Single submitter
- TAF1B p.Ser515Cys Uncertain significance Single submitter
- TAF1B p.Ser555Phe Uncertain significance Single submitter
- TAF1B p.Ser574Arg Uncertain significance Single submitter
- TAF1B p.Thr133Met Uncertain significance Single submitter
- TAF1B p.Thr32Ile Uncertain significance Single submitter
- TAF1B p.Thr507Asn Uncertain significance Single submitter
- TAF1B p.Trp418Gly Uncertain significance Single submitter
- TAF1B p.Tyr259Cys Uncertain significance Single submitter
- TAF1B p.Tyr301Cys Uncertain significance Single submitter
- TAF1B p.Tyr539Cys Uncertain significance Single submitter
- TAF1B p.Val207Met Uncertain significance Single submitter
- TAF1B p.Val450Met Uncertain significance Single submitter
- TAF1B p.Val585Glu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TAF1B p.Leu324Ser Uncertain significance Single submitter
- TAF1B p.Leu494His Uncertain significance Single submitter
- TAF1B p.Phe266Leu Uncertain significance Single submitter
- TAF1B p.Thr281Lys Uncertain significance Single submitter
- TAF1B p.Thr38Ile Uncertain significance Single submitter
- TAF1B p.Trp479Cys Uncertain significance Single submitter
- TAF1B p.Val561Met Uncertain significance Single submitter
All TAF1B variants
Likely benign 3
- p.Lys393Glu Single submitter
- p.Thr464Ala Single submitter
- p.Val178Ile Single submitter
Uncertain significance 71
- p.Ala164Val Single submitter ⚠
- p.Ala421Thr Single submitter ⚠
- p.Arg111His Single submitter ⚠
- p.Arg12Ser Single submitter ⚠
- p.Arg201Gln Single submitter ⚠
- p.Arg551Gly Single submitter
- p.Asn46Ser Single submitter ⚠
- p.Asn66fs Single submitter orofacial cleft 1
- p.Asn66Thr Single submitter ⚠
- p.Asp103Asn Single submitter ⚠
- p.Asp103Tyr Single submitter ⚠
- p.Asp439Asn Single submitter ⚠
- p.Asp485Gly Single submitter ⚠
- p.Asp485Val Single submitter ⚠
- p.Asp73Asn Single submitter ⚠
- p.Cys300Tyr Single submitter
- p.Gln183Leu Single submitter ⚠
- p.Gln503Arg Single submitter ⚠
- p.Glu185Gly Single submitter ⚠
- p.Glu275Lys Single submitter ⚠
- p.Glu419Asp Single submitter ⚠
- p.Glu419Lys Single submitter ⚠
- p.Glu500Gln Single submitter ⚠
- p.Gly205Arg Single submitter ⚠
- p.Gly22Cys Single submitter ⚠
- p.Gly502Val Single submitter ⚠
- p.His141Gln Single submitter ⚠
- p.His251Arg Single submitter ⚠
- p.His303Arg Single submitter ⚠
- p.His327Leu Single submitter ⚠
- p.Ile229Val Single submitter ⚠
- p.Ile246Val Single submitter ⚠
- p.Ile268Thr Single submitter ⚠
- p.Ile306Met Single submitter ⚠
- p.Ile306Thr Single submitter ⚠
- p.Ile345Val Single submitter ⚠
- p.Ile362Thr Single submitter ⚠
- p.Leu324Ser Single submitter ⚠
- p.Leu494His Single submitter ⚠
- p.Lys392Glu Single submitter ⚠
- p.Lys470Asn Single submitter ⚠
- p.Lys501Arg Single submitter ⚠
- p.Lys576Glu Single submitter ⚠
- p.Lys579Gln Single submitter ⚠
- p.Phe266Leu Single submitter ⚠
- p.Pro157Leu Single submitter ⚠
- p.Pro158Ala Single submitter ⚠
- p.Pro175Arg Single submitter ⚠
- p.Pro98Gln Single submitter ⚠
- p.Ser199Ala Single submitter ⚠
- p.Ser323Arg Single submitter ⚠
- p.Ser429Thr Single submitter ⚠
- p.Ser471Asn Single submitter ⚠
- p.Ser515Cys Single submitter ⚠
- p.Ser555Phe Single submitter ⚠
- p.Ser574Arg Single submitter ⚠
- p.Thr133Met Single submitter ⚠
- p.Thr281Lys Single submitter ⚠
- p.Thr32Ile Single submitter ⚠
- p.Thr38Ile Single submitter ⚠
- p.Thr507Asn Single submitter ⚠
- p.Trp418Gly Single submitter ⚠
- p.Trp479Cys Single submitter ⚠
- p.Tyr259Cys Single submitter ⚠
- p.Tyr301Cys Single submitter ⚠
- p.Tyr530Cys Single submitter
- p.Tyr539Cys Single submitter ⚠
- p.Val207Met Single submitter ⚠
- p.Val450Met Single submitter ⚠
- p.Val561Met Single submitter ⚠
- p.Val585Glu Single submitter ⚠