TAF5 — 50 ClinVar variants
All ClinVar germline TAF5 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
1 Benign · 1 Likely benign · 48 Uncertain significance
Full TAF5 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAF5 p.Ala647Gly Uncertain significance Single submitter
- TAF5 p.Ala647Val Uncertain significance Single submitter
- TAF5 p.Ala72Val Uncertain significance Single submitter
- TAF5 p.Arg280Gln Uncertain significance Single submitter
- TAF5 p.Asp343Val Uncertain significance Single submitter
- TAF5 p.Gly49Arg Uncertain significance Single submitter
- TAF5 p.Gly541Arg Uncertain significance Single submitter
- TAF5 p.Gly565Arg Uncertain significance Single submitter
- TAF5 p.Gly659Val Uncertain significance Single submitter
- TAF5 p.His673Gln Uncertain significance Single submitter
- TAF5 p.His784Tyr Uncertain significance Single submitter
- TAF5 p.Ile485Val Uncertain significance Single submitter
- TAF5 p.Lys503Arg Uncertain significance Single submitter
- TAF5 p.Lys518Arg Uncertain significance Single submitter
- TAF5 p.Pro346Leu Uncertain significance Single submitter
- TAF5 p.Pro553Leu Uncertain significance Single submitter
- TAF5 p.Pro679Ala Uncertain significance Single submitter
- TAF5 p.Ser189Gly Uncertain significance Single submitter
- TAF5 p.Ser219Gly Uncertain significance Single submitter
- TAF5 p.Ser283Thr Uncertain significance Single submitter
- TAF5 p.Ser313Leu Uncertain significance Single submitter
- TAF5 p.Ser506Asn Uncertain significance Single submitter
- TAF5 p.Thr493Ala Uncertain significance Single submitter
- TAF5 p.Thr633Ile Uncertain significance Single submitter
- TAF5 p.Thr713Ala Uncertain significance Single submitter
- TAF5 p.Thr753Asn Uncertain significance Single submitter
- TAF5 p.Val281Ile Uncertain significance Single submitter
- TAF5 p.Val384Ile Uncertain significance Single submitter
- TAF5 p.Val478Asp Uncertain significance Single submitter
- TAF5 p.Val546Ala Uncertain significance Single submitter
- TAF5 p.Val546Leu Uncertain significance Single submitter
- TAF5 p.Val608Ile Uncertain significance Single submitter
- TAF5 p.Val656Ile Uncertain significance Single submitter
- TAF5 p.Val656Phe Uncertain significance Single submitter
Predictors split 11
The independent predictors disagree with each other — read with care.
- TAF5 p.Arg308His Uncertain significance Single submitter
- TAF5 p.Arg505Cys Uncertain significance Single submitter
- TAF5 p.Arg505His Uncertain significance Single submitter
- TAF5 p.Arg736Gln Uncertain significance Single submitter
- TAF5 p.Asp750Asn Uncertain significance Single submitter
- TAF5 p.Gln471Arg Uncertain significance Single submitter
- TAF5 p.Glu257Asp Uncertain significance Single submitter
- TAF5 p.Leu432Phe Uncertain significance Single submitter
- TAF5 p.Pro455Leu Uncertain significance Single submitter
- TAF5 p.Ser56Phe Uncertain significance Single submitter
- TAF5 p.Tyr557His Uncertain significance Single submitter
All TAF5 variants
Benign 1
- p.Val476= Multiple submitters
Likely benign 1
- p.Ser54Ala Single submitter
Uncertain significance 48
- c.1665-2A>G Single submitter
- p.Ala533fs Single submitter
- p.Ala647Gly Single submitter ⚠
- p.Ala647Val Single submitter ⚠
- p.Ala72Val Single submitter ⚠
- p.Arg280Gln Single submitter ⚠
- p.Arg308His Single submitter ⚠
- p.Arg505Cys Single submitter ⚠
- p.Arg505His Single submitter ⚠
- p.Arg736Gln Single submitter ⚠
- p.Asp343Val Single submitter ⚠
- p.Asp750Asn Single submitter ⚠
- p.Gln471Arg Single submitter ⚠
- p.Glu257Asp Single submitter ⚠
- p.Gly49Arg Single submitter ⚠
- p.Gly541Arg Single submitter ⚠
- p.Gly565Arg Single submitter ⚠
- p.Gly659Val Single submitter ⚠
- p.His673Gln Single submitter ⚠
- p.His784Tyr Single submitter ⚠
- p.Ile485Val Single submitter ⚠
- p.Leu432Phe Single submitter ⚠
- p.Lys503Arg Single submitter ⚠
- p.Lys518Arg Single submitter ⚠
- p.Pro346Leu Single submitter ⚠
- p.Pro455Leu Single submitter ⚠
- p.Pro553Leu Single submitter ⚠
- p.Pro679Ala Single submitter ⚠
- p.Ser189Gly Single submitter ⚠
- p.Ser219Gly Single submitter ⚠
- p.Ser283Thr Single submitter ⚠
- p.Ser313Leu Single submitter ⚠
- p.Ser506Asn Single submitter ⚠
- p.Ser56Phe Single submitter ⚠
- p.Thr493Ala Single submitter ⚠
- p.Thr633Ile Single submitter ⚠
- p.Thr713Ala Single submitter ⚠
- p.Thr713Ile Single submitter
- p.Thr753Asn Single submitter ⚠
- p.Tyr557His Single submitter ⚠
- p.Val281Ile Single submitter ⚠
- p.Val384Ile Single submitter ⚠
- p.Val478Asp Single submitter ⚠
- p.Val546Ala Single submitter ⚠
- p.Val546Leu Single submitter ⚠
- p.Val608Ile Single submitter ⚠
- p.Val656Ile Single submitter ⚠
- p.Val656Phe Single submitter ⚠