TAGLN2 — 26 ClinVar variants
All ClinVar germline TAGLN2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 23 flagged for review →
26 Uncertain significance
Full TAGLN2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 23
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 13
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAGLN2 p.Ala184Val Uncertain significance Single submitter
- TAGLN2 p.Arg102His Uncertain significance Single submitter
- TAGLN2 p.Arg127Trp Uncertain significance Single submitter
- TAGLN2 p.Arg196His Uncertain significance Single submitter
- TAGLN2 p.Asn181Asp Uncertain significance Single submitter
- TAGLN2 p.Gln89His Uncertain significance Single submitter
- TAGLN2 p.Glu72Lys Uncertain significance Single submitter
- TAGLN2 p.Ile31Thr Uncertain significance Single submitter
- TAGLN2 p.Lys88Arg Uncertain significance Single submitter
- TAGLN2 p.Met90Arg Uncertain significance Single submitter
- TAGLN2 p.Pro159His Uncertain significance Single submitter
- TAGLN2 p.Tyr8Cys Uncertain significance Single submitter
- TAGLN2 p.Val173Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TAGLN2 p.Arg102Cys Uncertain significance Single submitter
- TAGLN2 p.Arg182Cys Uncertain significance Single submitter
- TAGLN2 p.Arg49Ser Uncertain significance Single submitter
- TAGLN2 p.Asp115Glu Uncertain significance Single submitter
- TAGLN2 p.Asp141His Uncertain significance Single submitter
- TAGLN2 p.Asp41Val Uncertain significance Single submitter
- TAGLN2 p.Gln197His Uncertain significance Single submitter
- TAGLN2 p.Met85Ile Uncertain significance Single submitter
- TAGLN2 p.Met85Val Uncertain significance Single submitter
- TAGLN2 p.Thr180Asn Uncertain significance Single submitter
All TAGLN2 variants
Uncertain significance 26
- p.Ala184Val Single submitter ⚠
- p.Arg102Cys Single submitter ⚠
- p.Arg102His Single submitter ⚠
- p.Arg127Gln Single submitter
- p.Arg127Trp Single submitter ⚠
- p.Arg182Cys Single submitter ⚠
- p.Arg196His Single submitter ⚠
- p.Arg49Ser Single submitter ⚠
- p.Asn158Thr Single submitter
- p.Asn181Asp Single submitter ⚠
- p.Asp115Glu Single submitter ⚠
- p.Asp141His Single submitter ⚠
- p.Asp41Val Single submitter ⚠
- p.Gln197His Single submitter ⚠
- p.Gln89His Single submitter ⚠
- p.Glu72Lys Single submitter ⚠
- p.Ile31Thr Single submitter ⚠
- p.Lys88Arg Single submitter ⚠
- p.Met85Ile Single submitter ⚠
- p.Met85Val Single submitter ⚠
- p.Met90Arg Single submitter ⚠
- p.Pro159His Single submitter ⚠
- p.Thr180Ala Single submitter
- p.Thr180Asn Single submitter ⚠
- p.Tyr8Cys Single submitter ⚠
- p.Val173Met Single submitter ⚠