TANK — 53 ClinVar variants
All ClinVar germline TANK variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
4 Benign · 1 Likely benign · 48 Uncertain significance
Full TANK gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 44
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TANK p.Ala327Val Uncertain significance Single submitter
- TANK p.Arg204Thr Uncertain significance Single submitter
- TANK p.Arg363Gln Uncertain significance Single submitter
- TANK p.Arg40Ser Uncertain significance Single submitter
- TANK p.Arg42Cys Uncertain significance Single submitter
- TANK p.Asn233Ser Uncertain significance Single submitter
- TANK p.Asn302Lys Uncertain significance Single submitter
- TANK p.Asn340His Uncertain significance Single submitter
- TANK p.Asn87Ser Uncertain significance Single submitter
- TANK p.Asn88Ile Uncertain significance Single submitter
- TANK p.Asp294Glu Uncertain significance Single submitter
- TANK p.Asp307Gly Uncertain significance Single submitter
- TANK p.Asp70Gly Uncertain significance Single submitter
- TANK p.Gln31Arg Uncertain significance Single submitter
- TANK p.Glu222Ala Uncertain significance Single submitter
- TANK p.Glu222Lys Uncertain significance Single submitter
- TANK p.Glu267Gln Uncertain significance Single submitter
- TANK p.Glu284Gln Uncertain significance Single submitter
- TANK p.Glu289Lys Uncertain significance Single submitter
- TANK p.His150Arg Uncertain significance Single submitter
- TANK p.Ile102Thr Uncertain significance Single submitter
- TANK p.Ile300Val Uncertain significance Single submitter
- TANK p.Ile319Ser Uncertain significance Single submitter
- TANK p.Ile99Thr Uncertain significance Single submitter
- TANK p.Lys109Glu Uncertain significance Single submitter
- TANK p.Lys140Asn Uncertain significance Single submitter
- TANK p.Lys186Thr Uncertain significance Single submitter
- TANK p.Lys189Asn Uncertain significance Single submitter
- TANK p.Met239Ile Uncertain significance Single submitter
- TANK p.Phe226Val Uncertain significance Single submitter
- TANK p.Phe273Ser Uncertain significance Single submitter
- TANK p.Pro207Ser Uncertain significance Single submitter
- TANK p.Pro372Ser Uncertain significance Single submitter
- TANK p.Pro94Gln Uncertain significance Single submitter
- TANK p.Ser225Phe Uncertain significance Single submitter
- TANK p.Ser243Leu Uncertain significance Single submitter
- TANK p.Ser357Cys Uncertain significance Single submitter
- TANK p.Ser380Pro Uncertain significance Single submitter
- TANK p.Thr184Ser Uncertain significance Single submitter
- TANK p.Thr224Ile Uncertain significance Single submitter
- TANK p.Thr249Ile Uncertain significance Single submitter
- TANK p.Thr260Met Uncertain significance Single submitter
- TANK p.Thr305Lys Uncertain significance Single submitter
- TANK p.Tyr73Cys Uncertain significance Single submitter
Predictors split 1
The independent predictors disagree with each other — read with care.
All TANK variants
Benign 4
- p.Ala198= Multiple submitters
- p.Gln113Glu Multiple submitters
- p.Pro358Leu Multiple submitters
- c.1101+6T>C Single submitter
Likely benign 1
- p.Thr68Ser Single submitter
Uncertain significance 48
- p.Ala327Val Single submitter ⚠
- p.Arg204Thr Single submitter ⚠
- p.Arg363Gln Single submitter ⚠
- p.Arg40Ser Single submitter ⚠
- p.Arg42Cys Single submitter ⚠
- p.Asn233Ser Single submitter ⚠
- p.Asn302Lys Single submitter ⚠
- p.Asn340His Single submitter ⚠
- p.Asn87Ser Single submitter ⚠
- p.Asn88Ile Single submitter ⚠
- p.Asp294Glu Single submitter ⚠
- p.Asp307Gly Single submitter ⚠
- p.Asp70Gly Single submitter ⚠
- p.Gln182Pro Single submitter
- p.Gln31Arg Single submitter ⚠
- p.Gln47Ter Single submitter
- p.Glu222Ala Single submitter ⚠
- p.Glu222Lys Single submitter ⚠
- p.Glu267Gln Single submitter ⚠
- p.Glu284Gln Single submitter ⚠
- p.Glu289Lys Single submitter ⚠
- p.His150Arg Single submitter ⚠
- p.Ile102Thr Single submitter ⚠
- p.Ile300Val Single submitter ⚠
- p.Ile319Ser Single submitter ⚠
- p.Ile5Thr Single submitter
- p.Ile99Thr Single submitter ⚠
- p.Lys109Glu Single submitter ⚠
- p.Lys140Asn Single submitter ⚠
- p.Lys186Thr Single submitter ⚠
- p.Lys189Asn Single submitter ⚠
- p.Met239Ile Single submitter ⚠
- p.Phe226Val Single submitter ⚠
- p.Phe273Ser Single submitter ⚠
- p.Pro207Ser Single submitter ⚠
- p.Pro372Ser Single submitter ⚠
- p.Pro94Gln Single submitter ⚠
- p.Ser225Phe Single submitter ⚠
- p.Ser243Leu Single submitter ⚠
- p.Ser357Cys Single submitter ⚠
- p.Ser380Pro Single submitter ⚠
- p.Thr184Ser Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr249Ile Single submitter ⚠
- p.Thr260Met Single submitter ⚠
- p.Thr305Lys Single submitter ⚠
- p.Tyr73Cys Single submitter ⚠
- p.Val234Phe Single submitter ⚠