TAOK3 — 87 ClinVar variants
All ClinVar germline TAOK3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 78 flagged for review →
2 Benign · 4 Likely benign · 81 Uncertain significance
Full TAOK3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 78
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 65
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAOK3 p.Ala501Thr Uncertain significance Single submitter
- TAOK3 p.Ala527Thr Uncertain significance Single submitter
- TAOK3 p.Ala793Thr Uncertain significance Single submitter
- TAOK3 p.Arg279Gln Uncertain significance Single submitter
- TAOK3 p.Arg281Gln Uncertain significance Single submitter
- TAOK3 p.Arg317Trp Uncertain significance Single submitter
- TAOK3 p.Arg468Trp Uncertain significance Single submitter
- TAOK3 p.Arg469His Uncertain significance Single submitter
- TAOK3 p.Arg490Cys Uncertain significance Single submitter
- TAOK3 p.Arg613Cys Uncertain significance Single submitter
- TAOK3 p.Arg623Gln Uncertain significance Single submitter
- TAOK3 p.Arg657Gln Uncertain significance Single submitter
- TAOK3 p.Arg676Cys Uncertain significance Single submitter
- TAOK3 p.Arg77Gln Uncertain significance Single submitter
- TAOK3 p.Asn176Ser Uncertain significance Single submitter
- TAOK3 p.Asn611Ser Uncertain significance Single submitter
- TAOK3 p.Asp13Asn Uncertain significance Single submitter
- TAOK3 p.Asp275Val Uncertain significance Single submitter
- TAOK3 p.Asp383Asn Uncertain significance Single submitter
- TAOK3 p.Asp529Gly Uncertain significance Single submitter
- TAOK3 p.Gln242Lys Uncertain significance Single submitter
- TAOK3 p.Gln541Arg Uncertain significance Single submitter
- TAOK3 p.Gln823Pro Uncertain significance Single submitter
- TAOK3 p.Glu377Lys Uncertain significance Single submitter
- TAOK3 p.Glu625Lys Uncertain significance Single submitter
- TAOK3 p.Gly334Arg Uncertain significance Single submitter
- TAOK3 p.Gly410Asp Uncertain significance Single submitter
- TAOK3 p.Gly59Arg Uncertain significance Single submitter
- TAOK3 p.His129Gln Uncertain significance Single submitter
- TAOK3 p.His28Asn Uncertain significance Single submitter
- TAOK3 p.His599Gln Uncertain significance Single submitter
- TAOK3 p.Ile11Thr Uncertain significance Single submitter
- TAOK3 p.Ile287Thr Uncertain significance Single submitter
- TAOK3 p.Ile290Thr Uncertain significance Single submitter
- TAOK3 p.Ile69Ser Uncertain significance Single submitter
- TAOK3 p.Leu828Phe Uncertain significance Single submitter
- TAOK3 p.Lys54Met Uncertain significance Single submitter
- TAOK3 p.Lys560Thr Uncertain significance Single submitter
- TAOK3 p.Lys584Arg Uncertain significance Single submitter
- TAOK3 p.Lys817Arg Uncertain significance Single submitter
- TAOK3 p.Met101Thr Uncertain significance Single submitter
- TAOK3 p.Met224Val Uncertain significance Single submitter
- TAOK3 p.Met341Thr Uncertain significance Single submitter
- TAOK3 p.Met380Ile Uncertain significance Single submitter
- TAOK3 p.Met620Thr Uncertain significance Single submitter
- TAOK3 p.Met715Ile Uncertain significance Single submitter
- TAOK3 p.Met780Val Uncertain significance Single submitter
- TAOK3 p.Met877Ile Uncertain significance Single submitter
- TAOK3 p.Met877Leu Uncertain significance Single submitter
- TAOK3 p.Ser324Pro Uncertain significance Single submitter
- TAOK3 p.Thr128Ala Uncertain significance Single submitter
- TAOK3 p.Thr240Ala Uncertain significance Single submitter
- TAOK3 p.Thr240Met Uncertain significance Single submitter
- TAOK3 p.Thr316Ser Uncertain significance Single submitter
- TAOK3 p.Thr499Met Uncertain significance Single submitter
- TAOK3 p.Thr602Ser Uncertain significance Single submitter
- TAOK3 p.Tyr57Cys Uncertain significance Single submitter
- TAOK3 p.Tyr57Ser Uncertain significance Single submitter
- TAOK3 p.Tyr661Asn Uncertain significance Single submitter
- TAOK3 p.Val179Met Uncertain significance Single submitter
- TAOK3 p.Val394Ile Uncertain significance Single submitter
- TAOK3 p.Val395Met Uncertain significance Single submitter
- TAOK3 p.Val525Ala Uncertain significance Single submitter
- TAOK3 p.Val888Phe Uncertain significance Single submitter
-
TAOK3 p.Met171Thr
Uncertain significance
No assertion criteria
prostate cancer
Predictors split 13
The independent predictors disagree with each other — read with care.
- TAOK3 p.Ala12Asp Uncertain significance Single submitter
- TAOK3 p.Arg298Ser Uncertain significance Single submitter
- TAOK3 p.Arg617Gln Uncertain significance Single submitter
- TAOK3 p.Asp248Val Uncertain significance Single submitter
- TAOK3 p.Gln242Pro Uncertain significance Single submitter
- TAOK3 p.Gln555Leu Uncertain significance Single submitter
- TAOK3 p.Glu580Gly Uncertain significance Single submitter
- TAOK3 p.Leu667Ser Uncertain significance Single submitter
- TAOK3 p.Met308Ile Uncertain significance Single submitter
- TAOK3 p.Pro82Leu Uncertain significance Single submitter
- TAOK3 p.Ser879Asn Uncertain significance Single submitter
- TAOK3 p.Thr437Met Uncertain significance Single submitter
- TAOK3 p.Thr445Ile Uncertain significance Single submitter
All TAOK3 variants
Likely benign 4
- c.1330-3C>T Single submitter
- c.193-8T>C Single submitter
- c.2140-7T>C Single submitter
- p.Leu6Pro Single submitter
Uncertain significance 81
- p.Ala12Asp Single submitter ⚠
- p.Ala501Thr Single submitter ⚠
- p.Ala527Thr Single submitter ⚠
- p.Ala793Thr Single submitter ⚠
- p.Arg279Gln Single submitter ⚠
- p.Arg281Gln Single submitter ⚠
- p.Arg298Ser Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Arg468Trp Single submitter ⚠
- p.Arg469His Single submitter ⚠
- p.Arg490Cys Single submitter ⚠
- p.Arg613Cys Single submitter ⚠
- p.Arg617Gln Single submitter ⚠
- p.Arg623Gln Single submitter ⚠
- p.Arg657Gln Single submitter ⚠
- p.Arg676Cys Single submitter ⚠
- p.Arg77Gln Single submitter ⚠
- p.Arg857Cys Single submitter
- p.Asn176Ser Single submitter ⚠
- p.Asn611Ser Single submitter ⚠
- p.Asp13Asn Single submitter ⚠
- p.Asp248Val Single submitter ⚠
- p.Asp275Val Single submitter ⚠
- p.Asp383Asn Single submitter ⚠
- p.Asp529Gly Single submitter ⚠
- p.Gln242Lys Single submitter ⚠
- p.Gln242Pro Single submitter ⚠
- p.Gln541Arg Single submitter ⚠
- p.Gln555Leu Single submitter ⚠
- p.Gln823Pro Single submitter ⚠
- p.Glu377Lys Single submitter ⚠
- p.Glu580Gly Single submitter ⚠
- p.Glu625Lys Single submitter ⚠
- p.Gly334Arg Single submitter ⚠
- p.Gly410Asp Single submitter ⚠
- p.Gly59Arg Single submitter ⚠
- p.His129Gln Single submitter ⚠
- p.His28Asn Single submitter ⚠
- p.His599Gln Single submitter ⚠
- p.Ile11Thr Single submitter ⚠
- p.Ile287Thr Single submitter ⚠
- p.Ile290Thr Single submitter ⚠
- p.Ile69Ser Single submitter ⚠
- p.Leu667Ser Single submitter ⚠
- p.Leu828Phe Single submitter ⚠
- p.Lys465Arg Single submitter
- p.Lys54Met Single submitter ⚠
- p.Lys560Thr Single submitter ⚠
- p.Lys584Arg Single submitter ⚠
- p.Lys817Arg Single submitter ⚠
- p.Met101Thr Single submitter ⚠
- p.Met224Val Single submitter ⚠
- p.Met308Ile Single submitter ⚠
- p.Met341Thr Single submitter ⚠
- p.Met380Ile Single submitter ⚠
- p.Met620Thr Single submitter ⚠
- p.Met715Ile Single submitter ⚠
- p.Met780Val Single submitter ⚠
- p.Met877Ile Single submitter ⚠
- p.Met877Leu Single submitter ⚠
- p.Pro82Leu Single submitter ⚠
- p.Ser324Pro Single submitter ⚠
- p.Ser336_Leu337insTer Single submitter neurodevelopmental disorder
- p.Ser879Asn Single submitter ⚠
- p.Thr128Ala Single submitter ⚠
- p.Thr240Ala Single submitter ⚠
- p.Thr240Met Single submitter ⚠
- p.Thr316Ser Single submitter ⚠
- p.Thr437Met Single submitter ⚠
- p.Thr445Ile Single submitter ⚠
- p.Thr499Met Single submitter ⚠
- p.Thr602Ser Single submitter ⚠
- p.Tyr57Cys Single submitter ⚠
- p.Tyr57Ser Single submitter ⚠
- p.Tyr661Asn Single submitter ⚠
- p.Val179Met Single submitter ⚠
- p.Val394Ile Single submitter ⚠
- p.Val395Met Single submitter ⚠
- p.Val525Ala Single submitter ⚠
- p.Val888Phe Single submitter ⚠
- p.Met171Thr No assertion criteria prostate cancer ⚠