TARBP2 — 47 ClinVar variants
All ClinVar germline TARBP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 43 flagged for review →
2 Benign · 45 Uncertain significance
Full TARBP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 43
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TARBP2 p.Ala293Gly Uncertain significance Single submitter
- TARBP2 p.Ala334Thr Uncertain significance Single submitter
- TARBP2 p.Arg174Trp Uncertain significance Single submitter
- TARBP2 p.Arg200His Uncertain significance Single submitter
- TARBP2 p.Arg252Cys Uncertain significance Single submitter
- TARBP2 p.Arg259Gln Uncertain significance Single submitter
- TARBP2 p.Arg296Cys Uncertain significance Single submitter
- TARBP2 p.Arg353Cys Uncertain significance Single submitter
- TARBP2 p.Arg354Cys Uncertain significance Single submitter
- TARBP2 p.Arg354His Uncertain significance Single submitter
- TARBP2 p.Asp115Glu Uncertain significance Single submitter
- TARBP2 p.Cys14Ser Uncertain significance Single submitter
- TARBP2 p.Cys14Trp Uncertain significance Single submitter
- TARBP2 p.Glu20Asp Uncertain significance Single submitter
- TARBP2 p.Glu328Val Uncertain significance Single submitter
- TARBP2 p.Glu350Asp Uncertain significance Single submitter
- TARBP2 p.Glu4Lys Uncertain significance Single submitter
- TARBP2 p.Gly13Ser Uncertain significance Single submitter
- TARBP2 p.Gly15Glu Uncertain significance Single submitter
- TARBP2 p.Gly349Ser Uncertain significance Single submitter
- TARBP2 p.Gly97Arg Uncertain significance Single submitter
- TARBP2 p.Gly9Ser Uncertain significance Single submitter
- TARBP2 p.Leu16Pro Uncertain significance Single submitter
- TARBP2 p.Leu326Pro Uncertain significance Single submitter
- TARBP2 p.Lys93Glu Uncertain significance Single submitter
- TARBP2 p.Met100Val Uncertain significance Single submitter
- TARBP2 p.Pro123Ala Uncertain significance Single submitter
- TARBP2 p.Pro143Thr Uncertain significance Single submitter
- TARBP2 p.Pro144Ala Uncertain significance Single submitter
- TARBP2 p.Pro144Arg Uncertain significance Single submitter
- TARBP2 p.Pro144Ser Uncertain significance Single submitter
- TARBP2 p.Pro240His Uncertain significance Single submitter
- TARBP2 p.Pro333Leu Uncertain significance Single submitter
- TARBP2 p.Ser18Gly Uncertain significance Single submitter
- TARBP2 p.Ser299Asn Uncertain significance Single submitter
- TARBP2 p.Ser72Asn Uncertain significance Single submitter
- TARBP2 p.Val90Glu Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TARBP2 p.Arg280Leu Uncertain significance Single submitter
- TARBP2 p.Asn216Asp Uncertain significance Single submitter
- TARBP2 p.Cys73Tyr Uncertain significance Single submitter
- TARBP2 p.Gly172Ala Uncertain significance Single submitter
- TARBP2 p.Leu298Val Uncertain significance Single submitter
- TARBP2 p.Val68Leu Uncertain significance Single submitter
All TARBP2 variants
Benign 2
- c.423-3C>G Multiple submitters
- p.Ile314= Multiple submitters
Uncertain significance 45
- p.Ala293Gly Single submitter ⚠
- p.Ala334Thr Single submitter ⚠
- p.Arg174Trp Single submitter ⚠
- p.Arg200His Single submitter ⚠
- p.Arg252Cys Single submitter ⚠
- p.Arg259Gln Single submitter ⚠
- p.Arg269Gln Single submitter
- p.Arg280Leu Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg353Cys Single submitter ⚠
- p.Arg354Cys Single submitter ⚠
- p.Arg354His Single submitter ⚠
- p.Asn216Asp Single submitter ⚠
- p.Asp115Glu Single submitter ⚠
- p.Cys14Ser Single submitter ⚠
- p.Cys14Trp Single submitter ⚠
- p.Cys73Tyr Single submitter ⚠
- p.Glu20Asp Single submitter ⚠
- p.Glu328Val Single submitter ⚠
- p.Glu350Asp Single submitter ⚠
- p.Glu4Lys Single submitter ⚠
- p.Gly13Ser Single submitter ⚠
- p.Gly15Glu Single submitter ⚠
- p.Gly172Ala Single submitter ⚠
- p.Gly349Ser Single submitter ⚠
- p.Gly97Arg Single submitter ⚠
- p.Gly9Ser Single submitter ⚠
- p.Leu16Pro Single submitter ⚠
- p.Leu298Val Single submitter ⚠
- p.Leu326Pro Single submitter ⚠
- p.Lys93Glu Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met362Val Single submitter
- p.Pro123Ala Single submitter ⚠
- p.Pro143Thr Single submitter ⚠
- p.Pro144Ala Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro144Ser Single submitter ⚠
- p.Pro240His Single submitter ⚠
- p.Pro333Leu Single submitter ⚠
- p.Ser18Gly Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Ser72Asn Single submitter ⚠
- p.Val68Leu Single submitter ⚠
- p.Val90Glu Single submitter ⚠