TAS1R1 — 108 ClinVar variants
All ClinVar germline TAS1R1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 88 flagged for review →
4 Benign · 1 Benign/Likely benign · 10 Likely benign · 93 Uncertain significance
Full TAS1R1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 88
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 64
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS1R1 p.Leu163Val Uncertain significance Multiple submitters
- TAS1R1 p.Ala170Val Uncertain significance Single submitter
- TAS1R1 p.Ala227Thr Uncertain significance Single submitter
- TAS1R1 p.Ala280Thr Uncertain significance Single submitter
- TAS1R1 p.Ala342Thr Uncertain significance Single submitter
- TAS1R1 p.Ala407Val Uncertain significance Single submitter
- TAS1R1 p.Ala410Ser Uncertain significance Single submitter
- TAS1R1 p.Ala453Val Uncertain significance Single submitter
- TAS1R1 p.Ala600Ser Uncertain significance Single submitter
- TAS1R1 p.Ala613Glu Uncertain significance Single submitter
- TAS1R1 p.Ala706Val Uncertain significance Single submitter
- TAS1R1 p.Arg180Trp Uncertain significance Single submitter
- TAS1R1 p.Arg281Gly Uncertain significance Single submitter
- TAS1R1 p.Arg281Ser Uncertain significance Single submitter
- TAS1R1 p.Arg317Cys Uncertain significance Single submitter
- TAS1R1 p.Arg317Leu Uncertain significance Single submitter
- TAS1R1 p.Arg343Pro Uncertain significance Single submitter
- TAS1R1 p.Arg343Trp Uncertain significance Single submitter
- TAS1R1 p.Arg555His Uncertain significance Single submitter
- TAS1R1 p.Arg64Gly Uncertain significance Single submitter
- TAS1R1 p.Asn111Asp Uncertain significance Single submitter
- TAS1R1 p.Asn361Ser Uncertain significance Single submitter
- TAS1R1 p.Asn490Lys Uncertain significance Single submitter
- TAS1R1 p.Asn676His Uncertain significance Single submitter
- TAS1R1 p.Asn69Ser Uncertain significance Single submitter
- TAS1R1 p.Asn724Ser Uncertain significance Single submitter
- TAS1R1 p.Asn724Thr Uncertain significance Single submitter
- TAS1R1 p.Asn755Ser Uncertain significance Single submitter
- TAS1R1 p.Asn769Thr Uncertain significance Single submitter
- TAS1R1 p.Cys352Ser Uncertain significance Single submitter
- TAS1R1 p.Cys497Tyr Uncertain significance Single submitter
- TAS1R1 p.Cys536Arg Uncertain significance Single submitter
- TAS1R1 p.Gln124Lys Uncertain significance Single submitter
- TAS1R1 p.Glu128Gly Uncertain significance Single submitter
- TAS1R1 p.Glu542Gly Uncertain significance Single submitter
- TAS1R1 p.Gly36Arg Uncertain significance Single submitter
- TAS1R1 p.Gly621Val Uncertain significance Single submitter
- TAS1R1 p.His24Arg Uncertain significance Single submitter
- TAS1R1 p.His426Leu Uncertain significance Single submitter
- TAS1R1 p.Ile740Thr Uncertain significance Single submitter
- TAS1R1 p.Leu34Phe Uncertain significance Single submitter
- TAS1R1 p.Leu656Pro Uncertain significance Single submitter
- TAS1R1 p.Leu691Met Uncertain significance Single submitter
- TAS1R1 p.Lys295Glu Uncertain significance Single submitter
- TAS1R1 p.Lys530Glu Uncertain significance Single submitter
- TAS1R1 p.Pro161Leu Uncertain significance Single submitter
- TAS1R1 p.Pro165Leu Uncertain significance Single submitter
- TAS1R1 p.Pro459Ala Uncertain significance Single submitter
- TAS1R1 p.Pro546Arg Uncertain significance Single submitter
- TAS1R1 p.Ser412Cys Uncertain significance Single submitter
- TAS1R1 p.Ser567Ala Uncertain significance Single submitter
- TAS1R1 p.Thr139Met Uncertain significance Single submitter
- TAS1R1 p.Thr374Met Uncertain significance Single submitter
- TAS1R1 p.Thr462Asn Uncertain significance Single submitter
- TAS1R1 p.Thr627Ser Uncertain significance Single submitter
- TAS1R1 p.Thr664Ser Uncertain significance Single submitter
- TAS1R1 p.Thr668Ser Uncertain significance Single submitter
- TAS1R1 p.Thr702Ala Uncertain significance Single submitter
- TAS1R1 p.Trp697Cys Uncertain significance Single submitter
- TAS1R1 p.Tyr670Cys Uncertain significance Single submitter
- TAS1R1 p.Tyr783Asn Uncertain significance Single submitter
- TAS1R1 p.Val324Met Uncertain significance Single submitter
- TAS1R1 p.Val683Ala Uncertain significance Single submitter
- TAS1R1 p.Val700Leu Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- TAS1R1 p.Arg563Cys Uncertain significance Single submitter
- TAS1R1 p.Arg634Gly Uncertain significance Single submitter
- TAS1R1 p.Arg80Gln Uncertain significance Single submitter
- TAS1R1 p.Arg80Trp Uncertain significance Single submitter
- TAS1R1 p.Gly314Arg Uncertain significance Single submitter
- TAS1R1 p.Gly678Ser Uncertain significance Single submitter
- TAS1R1 p.Gly785Ser Uncertain significance Single submitter
- TAS1R1 p.His505Asp Uncertain significance Single submitter
- TAS1R1 p.Ile144Thr Uncertain significance Single submitter
- TAS1R1 p.Leu40Met Uncertain significance Single submitter
- TAS1R1 p.Leu466Val Likely benign Single submitter
- TAS1R1 p.Leu571Arg Uncertain significance Single submitter
- TAS1R1 p.Phe185Leu Uncertain significance Single submitter
- TAS1R1 p.Phe206Leu Uncertain significance Single submitter
- TAS1R1 p.Phe553Ser Uncertain significance Single submitter
- TAS1R1 p.Pro493Leu Uncertain significance Single submitter
- TAS1R1 p.Ser549Arg Uncertain significance Single submitter
- TAS1R1 p.Ser653Leu Uncertain significance Single submitter
- TAS1R1 p.Ser765Gly Uncertain significance Single submitter
- TAS1R1 p.Thr209Ile Uncertain significance Single submitter
- TAS1R1 p.Tyr417Cys Uncertain significance Single submitter
- TAS1R1 p.Tyr813Ser Uncertain significance Single submitter
- TAS1R1 p.Val270Ile Uncertain significance Single submitter
- TAS1R1 p.Val287Met Uncertain significance Single submitter
All TAS1R1 variants
Benign 4
- p.Arg603His Multiple submitters
- p.Gln181Glu Multiple submitters
- p.His373Asn Multiple submitters
- p.Ser67= Multiple submitters
Benign/Likely benign 1
- p.Arg603Cys Multiple submitters
Likely benign 10
- p.Arg415Gln Single submitter
- p.Gln368Glu Single submitter
- p.Gly10Ser Single submitter
- p.His714Gln Single submitter
- p.Ile96Val Single submitter
- p.Leu466Val Single submitter ⚠
- p.Phe21Leu Single submitter
- p.Thr510Met Single submitter
- p.Val164Met Single submitter
- p.Val683fs Single submitter
Uncertain significance 93
- p.Leu163Val Multiple submitters ⚠
- p.Ala170Val Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala280Thr Single submitter ⚠
- p.Ala342Thr Single submitter ⚠
- p.Ala407Val Single submitter ⚠
- p.Ala410Ser Single submitter ⚠
- p.Ala453Val Single submitter ⚠
- p.Ala600Ser Single submitter ⚠
- p.Ala613Glu Single submitter ⚠
- p.Ala706Val Single submitter ⚠
- p.Arg180Trp Single submitter ⚠
- p.Arg281Gly Single submitter ⚠
- p.Arg281Ser Single submitter ⚠
- p.Arg317Cys Single submitter ⚠
- p.Arg317Leu Single submitter ⚠
- p.Arg343Pro Single submitter ⚠
- p.Arg343Trp Single submitter ⚠
- p.Arg555His Single submitter ⚠
- p.Arg563Cys Single submitter ⚠
- p.Arg634Gly Single submitter ⚠
- p.Arg64Gly Single submitter ⚠
- p.Arg80Gln Single submitter ⚠
- p.Arg80Trp Single submitter ⚠
- p.Asn111Asp Single submitter ⚠
- p.Asn361Ser Single submitter ⚠
- p.Asn490Lys Single submitter ⚠
- p.Asn676His Single submitter ⚠
- p.Asn69Ser Single submitter ⚠
- p.Asn724Ser Single submitter ⚠
- p.Asn724Thr Single submitter ⚠
- p.Asn755Ser Single submitter ⚠
- p.Asn769Thr Single submitter ⚠
- p.Cys352Ser Single submitter ⚠
- p.Cys497Tyr Single submitter ⚠
- p.Cys536Arg Single submitter ⚠
- p.Gln124Lys Single submitter ⚠
- p.Gln12Ter Single submitter
- p.Glu128Gly Single submitter ⚠
- p.Glu542Gly Single submitter ⚠
- p.Gly314Arg Single submitter ⚠
- p.Gly36Arg Single submitter ⚠
- p.Gly621Val Single submitter ⚠
- p.Gly678Ser Single submitter ⚠
- p.Gly785Ser Single submitter ⚠
- p.His24Arg Single submitter ⚠
- p.His426Leu Single submitter ⚠
- p.His505Asp Single submitter ⚠
- p.Ile144Thr Single submitter ⚠
- p.Ile740Thr Single submitter ⚠
- p.Leu34Phe Single submitter ⚠
- p.Leu40Met Single submitter ⚠
- p.Leu571Arg Single submitter ⚠
- p.Leu656Pro Single submitter ⚠
- p.Leu691Met Single submitter ⚠
- p.Lys295Glu Single submitter ⚠
- p.Lys530Glu Single submitter ⚠
- p.Met166Lys Single submitter
- p.Met260Thr Single submitter
- p.Phe185Leu Single submitter ⚠
- p.Phe206Leu Single submitter ⚠
- p.Phe370Ser Single submitter
- p.Phe553Ser Single submitter ⚠
- p.Pro161Leu Single submitter ⚠
- p.Pro165Leu Single submitter ⚠
- p.Pro459Ala Single submitter ⚠
- p.Pro493Leu Single submitter ⚠
- p.Pro546Arg Single submitter ⚠
- p.Ser177Arg Single submitter
- p.Ser412Cys Single submitter ⚠
- p.Ser549Arg Single submitter ⚠
- p.Ser567Ala Single submitter ⚠
- p.Ser611Pro Single submitter
- p.Ser653Leu Single submitter ⚠
- p.Ser765Gly Single submitter ⚠
- p.Thr139Met Single submitter ⚠
- p.Thr209Ile Single submitter ⚠
- p.Thr374Met Single submitter ⚠
- p.Thr462Asn Single submitter ⚠
- p.Thr627Ser Single submitter ⚠
- p.Thr664Ser Single submitter ⚠
- p.Thr668Ser Single submitter ⚠
- p.Thr702Ala Single submitter ⚠
- p.Trp697Cys Single submitter ⚠
- p.Tyr417Cys Single submitter ⚠
- p.Tyr670Cys Single submitter ⚠
- p.Tyr783Asn Single submitter ⚠
- p.Tyr813Ser Single submitter ⚠
- p.Val270Ile Single submitter ⚠
- p.Val287Met Single submitter ⚠
- p.Val324Met Single submitter ⚠
- p.Val683Ala Single submitter ⚠
- p.Val700Leu Single submitter ⚠