TAS1R2 — 177 ClinVar variants

All ClinVar germline TAS1R2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 149 flagged for review →

4 Benign · 10 Likely benign · 163 Uncertain significance

Full TAS1R2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 149

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 117

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 32

The independent predictors disagree with each other — read with care.

All TAS1R2 variants

Benign 4

p.Phe745= Multiple submitters
p.Pro21Leu Multiple submitters
c.1468-8C>T Single submitter
p.Asp443= Single submitter

Likely benign 10

p.Ala369Thr Single submitter
p.Ala782Val Single submitter
p.Gly696Ser Single submitter
p.Gly91Asp Single submitter
p.Ser144= Single submitter
p.Thr485= Single submitter
p.Val288= Single submitter
p.Val444Met Single submitter
p.Val465Ile Single submitter
p.Val774Ile Single submitter

Uncertain significance 163

p.Ala235Thr Single submitter ⚠
p.Ala296Ser Single submitter ⚠
p.Ala300Thr Single submitter ⚠
p.Ala466Thr Single submitter ⚠
p.Ala537Asp Single submitter ⚠
p.Ala537Gly Single submitter ⚠
p.Ala573Gly Single submitter ⚠
p.Ala78Val Single submitter ⚠
p.Arg134His Single submitter ⚠
p.Arg176Gly Single submitter ⚠
p.Arg182Gly Single submitter ⚠
p.Arg182His Single submitter ⚠
p.Arg182Ser Single submitter ⚠
p.Arg202Pro Single submitter
p.Arg217His Single submitter ⚠
p.Arg226His Single submitter ⚠
p.Arg226Ser Single submitter ⚠
p.Arg229Gln Single submitter ⚠
p.Arg229Pro Single submitter ⚠
p.Arg229Trp Single submitter ⚠
p.Arg254Cys Single submitter ⚠
p.Arg256Ser Single submitter ⚠
p.Arg270Cys Single submitter
p.Arg290His Single submitter ⚠
p.Arg339Cys Single submitter ⚠
p.Arg457Trp Single submitter ⚠
p.Arg473Gln Single submitter ⚠
p.Arg498Gly Single submitter ⚠
p.Arg554Trp Single submitter
p.Arg633Cys Single submitter ⚠
p.Arg633Gly Single submitter ⚠
p.Arg633His Single submitter ⚠
p.Arg651His Single submitter ⚠
p.Arg664Cys Single submitter ⚠
p.Arg664His Single submitter ⚠
p.Arg667Cys Single submitter ⚠
p.Arg725Cys Single submitter ⚠
p.Arg725His Single submitter ⚠
p.Arg76Cys Single submitter
p.Arg76His Single submitter ⚠
p.Arg821His Single submitter ⚠
p.Asn143Asp Single submitter ⚠
p.Asn143Ser Single submitter ⚠
p.Asn24Lys Single submitter ⚠
p.Asn488Ser Single submitter ⚠
p.Asp173His Single submitter ⚠
p.Asp188Asn Single submitter ⚠
p.Asp213Asn Single submitter ⚠
p.Asp218Asn Single submitter ⚠
p.Asp364Asn Single submitter ⚠
p.Asp439Asn Single submitter ⚠
p.Asp456Asn Single submitter ⚠
p.Asp711Asn Single submitter ⚠
p.Asp712Asn Single submitter ⚠
p.Cys359Arg Single submitter ⚠
p.Cys363Gly Single submitter ⚠
p.Cys535Tyr Single submitter ⚠
p.Gln247Glu Single submitter ⚠
p.Gln355Glu Single submitter ⚠
p.Gln361Glu Single submitter ⚠
p.Glu145Lys Single submitter ⚠
p.Glu192Lys Single submitter ⚠
p.Glu287Asp Single submitter ⚠
p.Glu302Lys Single submitter ⚠
p.Glu340Asp Single submitter ⚠
p.Glu534Ala Single submitter ⚠
p.Glu542Lys Single submitter ⚠
p.Glu563Asp Single submitter ⚠
p.Gly224Cys Single submitter ⚠
p.Gly502Arg Single submitter ⚠
p.Gly523Asp Single submitter
p.Gly523Ser Single submitter
p.Gly600Val Single submitter ⚠
p.Gly601Asp Single submitter ⚠
p.Gly68Ser Single submitter ⚠
p.Gly68Val Single submitter ⚠
p.Gly701Asp Single submitter ⚠
p.Gly785Arg Single submitter ⚠
p.Gly809Ser Single submitter ⚠
p.His200Arg Single submitter ⚠
p.His283Arg Single submitter ⚠
p.His283Gln Single submitter ⚠
p.His283Pro Single submitter ⚠
p.His42Arg Single submitter ⚠
p.Ile139Met Single submitter ⚠
p.Ile260Thr Single submitter ⚠
p.Ile299Phe Single submitter
p.Ile306Val Single submitter ⚠
p.Ile332Met Single submitter ⚠
p.Ile48Ser Single submitter ⚠
p.Ile518Val Single submitter ⚠
p.Ile567Phe Single submitter ⚠
p.Ile567Val Single submitter ⚠
p.Ile715Val Single submitter ⚠
p.Ile717Ser Single submitter
p.Ile790Phe Single submitter ⚠
p.Ile790Val Single submitter ⚠
p.Ile815Met Single submitter ⚠
p.Ile98Thr Single submitter ⚠
p.Leu14Val Single submitter ⚠
p.Leu154Phe Single submitter ⚠
p.Leu421Pro Single submitter ⚠
p.Leu556Pro Single submitter ⚠
p.Leu581Pro Single submitter ⚠
p.Leu688Pro Single submitter ⚠
p.Leu71Phe Single submitter ⚠
p.Leu88Val Single submitter ⚠
p.Leu89Met Single submitter ⚠
p.Lys476Thr Single submitter ⚠
p.Met148Val Single submitter ⚠
p.Met194Ile Single submitter ⚠
p.Met194Leu Single submitter ⚠
p.Met249Ile Single submitter ⚠
p.Met58Ile Single submitter ⚠
p.Met603Ile Single submitter
p.Met72Ile Single submitter ⚠
p.Met748Val Single submitter ⚠
p.Met766Leu Single submitter ⚠
p.Phe157Tyr Single submitter ⚠
p.Phe39Val Single submitter ⚠
p.Phe591Ile Single submitter ⚠
p.Phe779Leu Single submitter ⚠
p.Pro178Leu Single submitter ⚠
p.Pro185Arg Single submitter
p.Pro333Leu Single submitter ⚠
p.Pro347Leu Single submitter ⚠
p.Pro470Arg Single submitter ⚠
p.Pro624Leu Single submitter ⚠
p.Pro678His Single submitter
p.Ser133Phe Single submitter ⚠
p.Ser144Tyr Single submitter ⚠
p.Ser212Arg Single submitter
p.Ser25Leu Single submitter ⚠
p.Ser276Trp Single submitter ⚠
p.Ser390Phe Single submitter
p.Ser598Leu Single submitter ⚠
p.Ser663Gly Single submitter ⚠
p.Ser663Thr Single submitter ⚠
p.Thr239Met Single submitter ⚠
p.Thr250Ala Single submitter ⚠
p.Thr549Ile Single submitter ⚠
p.Thr566Ala Single submitter ⚠
p.Thr700Met Single submitter ⚠
p.Thr778Asn Single submitter ⚠
p.Thr823Met Single submitter ⚠
p.Thr823Ser Single submitter ⚠
p.Trp453Arg Single submitter ⚠
p.Tyr393Cys Single submitter ⚠
p.Tyr468His Single submitter ⚠
p.Tyr533Asn Single submitter ⚠
p.Tyr679Asp Single submitter ⚠
p.Tyr818His Single submitter ⚠
p.Val210Leu Single submitter ⚠
p.Val297Gly Single submitter ⚠
p.Val297Met Single submitter
p.Val330Ala Single submitter ⚠
p.Val385Ile Single submitter ⚠
p.Val585Met Single submitter ⚠
p.Val617Leu Single submitter ⚠
p.Val622Met Single submitter ⚠
p.Val650Met Single submitter ⚠
p.Val786Met Single submitter ⚠
p.Val99Met Single submitter ⚠