TAS1R3 — 269 ClinVar variants

All ClinVar germline TAS1R3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 217 flagged for review →

7 Benign · 30 Likely benign · 232 Uncertain significance

Full TAS1R3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 217

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors lean, ClinVar uncertain 184

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 184

Predictors split 33

The independent predictors disagree with each other — read with care.

All TAS1R3 variants

Benign 7

p.Ala735Thr Multiple submitters
p.Arg479= Multiple submitters
p.Gly367Cys Multiple submitters
p.Pro441= Multiple submitters
p.Pro597= Multiple submitters
p.Ser382= Multiple submitters
p.Ala46= Single submitter

Likely benign 30

p.Ala198Val Multiple submitters
p.Ala126= Single submitter
p.Ala282Thr Single submitter
p.Ala417Val Single submitter
p.Ala526= Single submitter
p.Ala579Val Single submitter
p.Arg123= Single submitter
p.Arg443Gln Single submitter
p.Arg498Gln Single submitter
p.Arg530Gln Single submitter
p.Arg594Trp Single submitter
p.Arg671Trp Single submitter
p.Arg752Gln Single submitter
p.Arg790= Single submitter
p.Arg819Trp Single submitter
p.Asp249Asn Single submitter
p.Asp445Asn Single submitter
p.Asp470= Single submitter
p.Asp491Gly Single submitter
p.Glu333Lys Single submitter
p.Gly355Asp Single submitter
p.Leu803= Single submitter
p.Ser251Leu Single submitter
p.Ser293= Single submitter
p.Ser577Gly Single submitter
p.Thr716= Single submitter
p.Tyr394= Single submitter
p.Val152Ile Single submitter
p.Val591Ile Single submitter
p.Val776Ile Single submitter

Uncertain significance 232

p.Phe474Ile Multiple submitters ⚠
p.Ala118Thr Single submitter ⚠
p.Ala127Thr Single submitter ⚠
p.Ala13Asp Single submitter ⚠
p.Ala176Thr Single submitter ⚠
p.Ala197Thr Single submitter ⚠
p.Ala210Thr Single submitter ⚠
p.Ala228Thr Single submitter ⚠
p.Ala231Thr Single submitter ⚠
p.Ala231Val Single submitter ⚠
p.Ala232Thr Single submitter ⚠
p.Ala232Val Single submitter ⚠
p.Ala279Thr Single submitter ⚠
p.Ala302Asp Single submitter
p.Ala316Val Single submitter ⚠
p.Ala329Gly Single submitter ⚠
p.Ala329Val Single submitter ⚠
p.Ala345Thr Single submitter ⚠
p.Ala353Thr Single submitter ⚠
p.Ala383Thr Single submitter ⚠
p.Ala395Thr Single submitter ⚠
p.Ala412Thr Single submitter ⚠
p.Ala417Thr Single submitter ⚠
p.Ala526Val Single submitter ⚠
p.Ala585Thr Single submitter ⚠
p.Ala635Val Single submitter ⚠
p.Ala655Val Single submitter
p.Ala733Glu Single submitter
p.Ala797Thr Single submitter ⚠
p.Ala797Val Single submitter ⚠
p.Ala807Pro Single submitter ⚠
p.Ala837Thr Single submitter ⚠
p.Arg123His Single submitter ⚠
p.Arg137His Single submitter ⚠
p.Arg177Gln Single submitter ⚠
p.Arg177Trp Single submitter ⚠
p.Arg185Cys Single submitter ⚠
p.Arg220Gln Single submitter ⚠
p.Arg233Cys Single submitter ⚠
p.Arg233His Single submitter ⚠
p.Arg247Cys Single submitter ⚠
p.Arg252Gln Single submitter ⚠
p.Arg252Trp Single submitter ⚠
p.Arg291Ser Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg369His Single submitter ⚠
p.Arg443Trp Single submitter ⚠
p.Arg467Ser Single submitter ⚠
p.Arg479Lys Single submitter ⚠
p.Arg498Trp Single submitter ⚠
p.Arg509Cys Single submitter ⚠
p.Arg509Ser Single submitter ⚠
p.Arg510Gln Single submitter ⚠
p.Arg52His Single submitter ⚠
p.Arg530Trp Single submitter ⚠
p.Arg54Gln Single submitter ⚠
p.Arg550Gln Single submitter ⚠
p.Arg553Cys Single submitter ⚠
p.Arg557His Single submitter
p.Arg558Gly Single submitter ⚠
p.Arg558Lys Single submitter ⚠
p.Arg560Gln Single submitter ⚠
p.Arg560Trp Single submitter ⚠
p.Arg677Gly Single submitter ⚠
p.Arg723His Single submitter ⚠
p.Arg725Cys Single submitter ⚠
p.Arg762Cys Single submitter ⚠
p.Arg762His Single submitter ⚠
p.Asn207Lys Single submitter
p.Asn386Tyr Single submitter ⚠
p.Asn406Asp Single submitter ⚠
p.Asn449Ser Single submitter ⚠
p.Asn847Ser Single submitter ⚠
p.Asn85Lys Single submitter ⚠
p.Asp124Asn Single submitter ⚠
p.Asp190Asn Single submitter ⚠
p.Asp190Tyr Single submitter ⚠
p.Asp190Val Single submitter ⚠
p.Asp215His Single submitter ⚠
p.Asp216Asn Single submitter ⚠
p.Asp216Glu Single submitter ⚠
p.Asp374Tyr Single submitter
p.Asp419Asn Single submitter ⚠
p.Asp455Asn Single submitter ⚠
p.Asp470Asn Single submitter ⚠
p.Asp520Asn Single submitter
p.Asp535Asn Single submitter ⚠
p.Asp535His Single submitter
p.Asp88Asn Single submitter ⚠
p.Asp98Glu Single submitter
p.Asp98Val Single submitter ⚠
p.Cys415Tyr Single submitter ⚠
p.Cys499Phe Single submitter ⚠
p.Cys521Tyr Single submitter ⚠
p.Cys524Arg Single submitter ⚠
p.Cys62Arg Single submitter ⚠
p.Gln372Arg Single submitter ⚠
p.Gln493Arg Single submitter ⚠
p.Gln531His Single submitter ⚠
p.Gln838Glu Single submitter ⚠
p.Glu148Asp Single submitter ⚠
p.Glu199Lys Single submitter ⚠
p.Glu217Lys Single submitter ⚠
p.Glu240Lys Single submitter ⚠
p.Glu333Asp Single submitter ⚠
p.Glu356Lys Single submitter ⚠
p.Glu363Asp Single submitter ⚠
p.Glu47Lys Single submitter ⚠
p.Glu545Lys Single submitter ⚠
p.Glu566Lys Single submitter ⚠
p.Glu657Lys Single submitter ⚠
p.Glu661Asp Single submitter ⚠
p.Glu663Gln Single submitter ⚠
p.Glu692Asp Single submitter ⚠
p.Glu692Gly Single submitter
p.Gly20Arg Single submitter ⚠
p.Gly219Ser Single submitter ⚠
p.Gly219Val Single submitter ⚠
p.Gly222Ser Single submitter ⚠
p.Gly234Ser Single submitter ⚠
p.Gly234Val Single submitter
p.Gly311Arg Single submitter ⚠
p.Gly311Glu Single submitter ⚠
p.Gly314Ser Single submitter ⚠
p.Gly33Arg Single submitter ⚠
p.Gly384Arg Single submitter ⚠
p.Gly384Glu Single submitter ⚠
p.Gly3Asp Single submitter ⚠
p.Gly448Ala Single submitter ⚠
p.Gly448Arg Single submitter ⚠
p.Gly513Arg Single submitter ⚠
p.Gly565Arg Single submitter ⚠
p.Gly603Glu Single submitter ⚠
p.Gly604Glu Single submitter ⚠
p.Gly615Ser Single submitter ⚠
p.Gly763Arg Single submitter ⚠
p.Gly763Ser Single submitter ⚠
p.Gly835Arg Single submitter ⚠
p.His145Arg Single submitter ⚠
p.His261Tyr Single submitter ⚠
p.His278Gln Single submitter ⚠
p.His278Tyr Single submitter ⚠
p.His488Arg Single submitter ⚠
p.His851Gln Single submitter ⚠
p.Ile125Val Single submitter ⚠
p.Ile658Met Single submitter ⚠
p.Leu114Pro Single submitter ⚠
p.Leu273Pro Single submitter ⚠
p.Leu29Phe Single submitter ⚠
p.Leu304Gln Single submitter ⚠
p.Leu458Pro Single submitter ⚠
p.Leu468Pro Single submitter ⚠
p.Leu478His Single submitter ⚠
p.Leu571Gln Single submitter ⚠
p.Leu573Pro Single submitter ⚠
p.Leu769Gln Single submitter ⚠
p.Leu93Pro Single submitter ⚠
p.Leu95Pro Single submitter ⚠
p.Leu99Phe Single submitter ⚠
p.Lys32Met Single submitter ⚠
p.Met151Thr Single submitter ⚠
p.Met162Ile Single submitter ⚠
p.Met162Val Single submitter ⚠
p.Met452Thr Single submitter ⚠
p.Phe183Ser Single submitter ⚠
p.Phe41Ile Single submitter ⚠
p.Phe590Ser Single submitter ⚠
p.Phe766Cys Single submitter ⚠
p.Phe828Val Single submitter ⚠
p.Pro144Ser Single submitter ⚠
p.Pro244Leu Single submitter ⚠
p.Pro246Thr Single submitter ⚠
p.Pro313Ala Single submitter ⚠
p.Pro348Ser Single submitter ⚠
p.Pro495Ser Single submitter ⚠
p.Pro533Leu Single submitter ⚠
p.Pro567Leu Single submitter ⚠
p.Pro638Leu Single submitter ⚠
p.Pro679Ser Single submitter ⚠
p.Pro704Leu Single submitter ⚠
p.Pro812Arg Single submitter ⚠
p.Pro826Arg Single submitter ⚠
p.Ser104Leu Single submitter ⚠
p.Ser104Trp Single submitter ⚠
p.Ser146Leu Single submitter ⚠
p.Ser170Cys Single submitter ⚠
p.Ser214Asn Single submitter ⚠
p.Ser289Asn Single submitter ⚠
p.Ser293Leu Single submitter ⚠
p.Ser306Pro Single submitter ⚠
p.Ser399Gly Single submitter ⚠
p.Ser629Arg Single submitter ⚠
p.Ser629Gly Single submitter ⚠
p.Ser87Leu Single submitter ⚠
p.Thr132Met Single submitter ⚠
p.Thr195Met Single submitter ⚠
p.Thr19Met Single submitter ⚠
p.Thr320Met Single submitter ⚠
p.Thr377Met Single submitter ⚠
p.Thr390Met Single submitter ⚠
p.Thr434Ile Single submitter ⚠
p.Thr480Ser Single submitter ⚠
p.Thr55Lys Single submitter ⚠
p.Thr739Met Single submitter ⚠
p.Thr825Ala Single submitter ⚠
p.Trp206Cys Single submitter ⚠
p.Tyr128Asp Single submitter ⚠
p.Tyr431Cys Single submitter ⚠
p.Val152Ala Single submitter ⚠
p.Val187Met Single submitter ⚠
p.Val243Met Single submitter ⚠
p.Val259Ile Single submitter ⚠
p.Val268Met Single submitter
p.Val277Met Single submitter ⚠
p.Val296Met Single submitter
p.Val338Leu Single submitter
p.Val338Met Single submitter ⚠
p.Val36Met Single submitter ⚠
p.Val381Met Single submitter ⚠
p.Val393Ile Single submitter ⚠
p.Val397Ala Single submitter ⚠
p.Val421Gly Single submitter
p.Val421Met Single submitter ⚠
p.Val450Met Single submitter ⚠
p.Val460Met Single submitter ⚠
p.Val471Met Single submitter ⚠
p.Val496Met Single submitter ⚠
p.Val522Glu Single submitter ⚠
p.Val522Met Single submitter ⚠
p.Val617Leu Single submitter ⚠
p.Val80Leu Single submitter ⚠
p.Val80Met Single submitter ⚠