TAS2R1 — 40 ClinVar variants
All ClinVar germline TAS2R1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
1 Benign · 4 Likely benign · 35 Uncertain significance
Full TAS2R1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R1 p.Ala173Ser Uncertain significance Single submitter
- TAS2R1 p.Ala80Val Uncertain significance Single submitter
- TAS2R1 p.Asn89Ser Uncertain significance Single submitter
- TAS2R1 p.Cys241Gly Uncertain significance Single submitter
- TAS2R1 p.Cys298Ser Uncertain significance Single submitter
- TAS2R1 p.Gln162Glu Uncertain significance Single submitter
- TAS2R1 p.Gln162Pro Uncertain significance Single submitter
- TAS2R1 p.Gln207Glu Uncertain significance Single submitter
- TAS2R1 p.Glu169Gly Uncertain significance Single submitter
- TAS2R1 p.Gly132Ala Uncertain significance Single submitter
- TAS2R1 p.Ile174Met Uncertain significance Single submitter
- TAS2R1 p.Ile56Asn Uncertain significance Single submitter
- TAS2R1 p.Leu279Phe Uncertain significance Single submitter
- TAS2R1 p.Leu60Phe Uncertain significance Single submitter
- TAS2R1 p.Lys124Asn Uncertain significance Single submitter
- TAS2R1 p.Lys296Arg Uncertain significance Single submitter
- TAS2R1 p.Met129Val Uncertain significance Single submitter
- TAS2R1 p.Phe159Ile Uncertain significance Single submitter
- TAS2R1 p.Phe179Ser Uncertain significance Single submitter
- TAS2R1 p.Pro282His Uncertain significance Single submitter
- TAS2R1 p.Pro43Ala Uncertain significance Single submitter
- TAS2R1 p.Ser145Gly Uncertain significance Single submitter
- TAS2R1 p.Ser215Gly Uncertain significance Single submitter
- TAS2R1 p.Thr171Ala Uncertain significance Single submitter
- TAS2R1 p.Thr97Ser Uncertain significance Single submitter
- TAS2R1 p.Trp98Arg Uncertain significance Single submitter
- TAS2R1 p.Tyr154His Uncertain significance Single submitter
- TAS2R1 p.Val101Ile Uncertain significance Single submitter
- TAS2R1 p.Val14Leu Uncertain significance Single submitter
- TAS2R1 p.Val217Phe Uncertain significance Single submitter
- TAS2R1 p.Val30Leu Uncertain significance Single submitter
Predictors split 4
The independent predictors disagree with each other — read with care.
All TAS2R1 variants
Benign 1
- p.Cys141Tyr Multiple submitters
Likely benign 4
- p.Arg121Lys Single submitter
- p.Arg206Gln Single submitter
- p.Glu92Gly Single submitter
- p.Ile235Val Single submitter
Uncertain significance 35
- p.Ala173Ser Single submitter ⚠
- p.Ala80Val Single submitter ⚠
- p.Asn89Ser Single submitter ⚠
- p.Cys241Gly Single submitter ⚠
- p.Cys298Ser Single submitter ⚠
- p.Gln162Glu Single submitter ⚠
- p.Gln162Pro Single submitter ⚠
- p.Gln207Glu Single submitter ⚠
- p.Gln59Arg Single submitter ⚠
- p.Glu169Gly Single submitter ⚠
- p.Gly132Ala Single submitter ⚠
- p.Ile122Thr Single submitter ⚠
- p.Ile174Met Single submitter ⚠
- p.Ile56Asn Single submitter ⚠
- p.Leu188Arg Single submitter ⚠
- p.Leu279Phe Single submitter ⚠
- p.Leu60Phe Single submitter ⚠
- p.Lys124Asn Single submitter ⚠
- p.Lys296Arg Single submitter ⚠
- p.Met129Val Single submitter ⚠
- p.Phe159Ile Single submitter ⚠
- p.Phe179Ser Single submitter ⚠
- p.Pro282His Single submitter ⚠
- p.Pro43Ala Single submitter ⚠
- p.Ser145Gly Single submitter ⚠
- p.Ser215Gly Single submitter ⚠
- p.Thr171Ala Single submitter ⚠
- p.Thr97Ser Single submitter ⚠
- p.Trp98Arg Single submitter ⚠
- p.Tyr154His Single submitter ⚠
- p.Val101Ile Single submitter ⚠
- p.Val14Leu Single submitter ⚠
- p.Val217Phe Single submitter ⚠
- p.Val30Leu Single submitter ⚠
- p.Val53Asp Single submitter ⚠