TAS2R14 — 43 ClinVar variants
All ClinVar germline TAS2R14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 35 flagged for review →
3 Benign · 5 Likely benign · 35 Uncertain significance
Full TAS2R14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 35
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 28
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R14 p.Ala146Thr Uncertain significance Single submitter
- TAS2R14 p.Arg83Lys Uncertain significance Single submitter
- TAS2R14 p.Asn113Ser Uncertain significance Single submitter
- TAS2R14 p.Asn144Lys Uncertain significance Single submitter
- TAS2R14 p.Asn87Asp Uncertain significance Single submitter
- TAS2R14 p.Asn87Ser Uncertain significance Single submitter
- TAS2R14 p.Cys278Tyr Uncertain significance Single submitter
- TAS2R14 p.Gln289Arg Uncertain significance Single submitter
- TAS2R14 p.Gly309Ser Uncertain significance Single submitter
- TAS2R14 p.His214Arg Uncertain significance Single submitter
- TAS2R14 p.His310Tyr Uncertain significance Single submitter
- TAS2R14 p.Ile148Arg Uncertain significance Single submitter
- TAS2R14 p.Ile152Leu Uncertain significance Single submitter
- TAS2R14 p.Leu264Val Uncertain significance Single submitter
- TAS2R14 p.Leu75Phe Uncertain significance Single submitter
- TAS2R14 p.Leu85Phe Uncertain significance Single submitter
- TAS2R14 p.Met205Ile Uncertain significance Single submitter
- TAS2R14 p.Met205Thr Uncertain significance Single submitter
- TAS2R14 p.Ser155Cys Uncertain significance Single submitter
- TAS2R14 p.Thr78Ala Uncertain significance Single submitter
- TAS2R14 p.Trp124Arg Uncertain significance Single submitter
- TAS2R14 p.Trp206Cys Uncertain significance Single submitter
- TAS2R14 p.Trp66Leu Uncertain significance Single submitter
- TAS2R14 p.Val233Met Uncertain significance Single submitter
- TAS2R14 p.Val294Leu Uncertain significance Single submitter
- TAS2R14 p.Val4Asp Uncertain significance Single submitter
- TAS2R14 p.Val59Ile Uncertain significance Single submitter
- TAS2R14 p.Val91Met Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TAS2R14 p.Arg209Gly Uncertain significance Single submitter
- TAS2R14 p.Arg288Ile Uncertain significance Single submitter
- TAS2R14 p.Arg55Gln Uncertain significance Single submitter
- TAS2R14 p.Arg55Gly Uncertain significance Single submitter
- TAS2R14 p.Phe119Cys Uncertain significance Single submitter
- TAS2R14 p.Pro273Leu Uncertain significance Single submitter
- TAS2R14 p.Val130Gly Uncertain significance Single submitter
All TAS2R14 variants
Likely benign 5
- p.Gly220Arg Single submitter
- p.Leu29= Single submitter
- p.Ser291Phe Single submitter
- p.Ser43Leu Single submitter
- p.Val12Ile Single submitter
Uncertain significance 35
- p.Ala146Thr Single submitter ⚠
- p.Arg209Gly Single submitter ⚠
- p.Arg288Ile Single submitter ⚠
- p.Arg55Gln Single submitter ⚠
- p.Arg55Gly Single submitter ⚠
- p.Arg83Lys Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asn144Lys Single submitter ⚠
- p.Asn87Asp Single submitter ⚠
- p.Asn87Ser Single submitter ⚠
- p.Cys278Tyr Single submitter ⚠
- p.Gln289Arg Single submitter ⚠
- p.Gly309Ser Single submitter ⚠
- p.His214Arg Single submitter ⚠
- p.His310Tyr Single submitter ⚠
- p.Ile148Arg Single submitter ⚠
- p.Ile152Leu Single submitter ⚠
- p.Leu264Val Single submitter ⚠
- p.Leu75Phe Single submitter ⚠
- p.Leu85Phe Single submitter ⚠
- p.Met205Ile Single submitter ⚠
- p.Met205Thr Single submitter ⚠
- p.Phe119Cys Single submitter ⚠
- p.Pro273Leu Single submitter ⚠
- p.Ser155Cys Single submitter ⚠
- p.Thr78Ala Single submitter ⚠
- p.Trp124Arg Single submitter ⚠
- p.Trp206Cys Single submitter ⚠
- p.Trp66Leu Single submitter ⚠
- p.Val130Gly Single submitter ⚠
- p.Val233Met Single submitter ⚠
- p.Val294Leu Single submitter ⚠
- p.Val4Asp Single submitter ⚠
- p.Val59Ile Single submitter ⚠
- p.Val91Met Single submitter ⚠