TAS2R3 — 44 ClinVar variants
All ClinVar germline TAS2R3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
4 Likely benign · 40 Uncertain significance
Full TAS2R3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R3 p.Ala163Thr Uncertain significance Single submitter
- TAS2R3 p.Ala228Gly Uncertain significance Single submitter
- TAS2R3 p.Ala278Pro Uncertain significance Single submitter
- TAS2R3 p.Ala52Glu Uncertain significance Single submitter
- TAS2R3 p.Arg212Gln Uncertain significance Single submitter
- TAS2R3 p.Arg212Gly Uncertain significance Single submitter
- TAS2R3 p.Arg212Trp Uncertain significance Single submitter
- TAS2R3 p.Arg300Gln Uncertain significance Single submitter
- TAS2R3 p.Glu151Asp Uncertain significance Single submitter
- TAS2R3 p.Glu6Asp Uncertain significance Single submitter
- TAS2R3 p.Glu6Lys Uncertain significance Single submitter
- TAS2R3 p.Gly304Val Uncertain significance Single submitter
- TAS2R3 p.Gly3Ala Uncertain significance Single submitter
- TAS2R3 p.His116Asp Uncertain significance Single submitter
- TAS2R3 p.Ile149Val Uncertain significance Single submitter
- TAS2R3 p.Ile27Thr Uncertain significance Single submitter
- TAS2R3 p.Ile283Val Uncertain significance Single submitter
- TAS2R3 p.Ile47Val Uncertain significance Single submitter
- TAS2R3 p.Leu120Phe Uncertain significance Single submitter
- TAS2R3 p.Leu139Val Uncertain significance Single submitter
- TAS2R3 p.Leu193Phe Uncertain significance Single submitter
- TAS2R3 p.Lys292Arg Uncertain significance Single submitter
- TAS2R3 p.Met264Ile Uncertain significance Single submitter
- TAS2R3 p.Met41Val Uncertain significance Single submitter
- TAS2R3 p.Phe152Ile Uncertain significance Single submitter
- TAS2R3 p.Phe36Leu Uncertain significance Single submitter
- TAS2R3 p.Phe46Leu Uncertain significance Single submitter
- TAS2R3 p.Ser147Tyr Uncertain significance Single submitter
- TAS2R3 p.Thr50Ile Uncertain significance Single submitter
- TAS2R3 p.Thr64Ala Uncertain significance Single submitter
- TAS2R3 p.Trp121Ser Uncertain significance Single submitter
- TAS2R3 p.Trp124Gly Uncertain significance Single submitter
- TAS2R3 p.Tyr200Cys Uncertain significance Single submitter
- TAS2R3 p.Val129Leu Uncertain significance Single submitter
- TAS2R3 p.Val167Gly Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R3 variants
Likely benign 4
- p.Ala249Ser Single submitter
- p.Ala265= Single submitter
- p.Leu12= Single submitter
- p.Ser96Asn Single submitter
Uncertain significance 40
- p.Ala163Thr Single submitter ⚠
- p.Ala228Gly Single submitter ⚠
- p.Ala278Pro Single submitter ⚠
- p.Ala52Glu Single submitter ⚠
- p.Ala52Val Single submitter ⚠
- p.Arg212Gln Single submitter ⚠
- p.Arg212Gly Single submitter ⚠
- p.Arg212Trp Single submitter ⚠
- p.Arg300Gln Single submitter ⚠
- p.Glu151Asp Single submitter ⚠
- p.Glu6Asp Single submitter ⚠
- p.Glu6Lys Single submitter ⚠
- p.Gly304Val Single submitter ⚠
- p.Gly3Ala Single submitter ⚠
- p.His116Asp Single submitter ⚠
- p.Ile149Val Single submitter ⚠
- p.Ile27Thr Single submitter ⚠
- p.Ile283Val Single submitter ⚠
- p.Ile47Val Single submitter ⚠
- p.Leu120Phe Single submitter ⚠
- p.Leu139Val Single submitter ⚠
- p.Leu187Pro Single submitter ⚠
- p.Leu193Phe Single submitter ⚠
- p.Leu299His Single submitter ⚠
- p.Lys292Arg Single submitter ⚠
- p.Met264Ile Single submitter ⚠
- p.Met41Val Single submitter ⚠
- p.Phe152Ile Single submitter ⚠
- p.Phe36Leu Single submitter ⚠
- p.Phe46Leu Single submitter ⚠
- p.Ser13Pro Single submitter ⚠
- p.Ser147Tyr Single submitter ⚠
- p.Ser88Pro Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Thr64Ala Single submitter ⚠
- p.Trp121Ser Single submitter ⚠
- p.Trp124Gly Single submitter ⚠
- p.Tyr200Cys Single submitter ⚠
- p.Val129Leu Single submitter ⚠
- p.Val167Gly Single submitter ⚠