TAS2R31 — 45 ClinVar variants
All ClinVar germline TAS2R31 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 42 flagged for review →
4 Likely benign · 41 Uncertain significance
Full TAS2R31 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 42
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R31 p.Ala266Gly Uncertain significance Single submitter
- TAS2R31 p.Ala266Val Uncertain significance Single submitter
- TAS2R31 p.Arg295Gln Uncertain significance Single submitter
- TAS2R31 p.Arg35Gln Uncertain significance Single submitter
- TAS2R31 p.Asn161Lys Uncertain significance Single submitter
- TAS2R31 p.Asn283Asp Uncertain significance Single submitter
- TAS2R31 p.Asn86Ser Uncertain significance Single submitter
- TAS2R31 p.Ile19Thr Uncertain significance Single submitter
- TAS2R31 p.Ile267Val Uncertain significance Single submitter
- TAS2R31 p.Ile280Met Uncertain significance Single submitter
- TAS2R31 p.Ile41Phe Uncertain significance Single submitter
- TAS2R31 p.Ile8Val Uncertain significance Single submitter
- TAS2R31 p.Leu185Val Uncertain significance Single submitter
- TAS2R31 p.Leu62Val Uncertain significance Single submitter
- TAS2R31 p.Lys126Arg Uncertain significance Single submitter
- TAS2R31 p.Lys265Asn Uncertain significance Single submitter
- TAS2R31 p.Lys284Glu Uncertain significance Single submitter
- TAS2R31 p.Met149Thr Uncertain significance Single submitter
- TAS2R31 p.Pro309Leu Uncertain significance Single submitter
- TAS2R31 p.Ser101Thr Uncertain significance Single submitter
- TAS2R31 p.Ser127Arg Uncertain significance Single submitter
- TAS2R31 p.Thr100Ala Uncertain significance Single submitter
- TAS2R31 p.Thr155Lys Uncertain significance Single submitter
- TAS2R31 p.Thr163Ile Uncertain significance Single submitter
- TAS2R31 p.Thr230Ile Uncertain significance Single submitter
- TAS2R31 p.Thr289Ser Uncertain significance Single submitter
- TAS2R31 p.Thr83Asn Uncertain significance Single submitter
- TAS2R31 p.Tyr76Asn Uncertain significance Single submitter
- TAS2R31 p.Tyr76His Uncertain significance Single submitter
- TAS2R31 p.Tyr85Cys Uncertain significance Single submitter
- TAS2R31 p.Val125Ile Uncertain significance Single submitter
- TAS2R31 p.Val13Ile Uncertain significance Single submitter
- TAS2R31 p.Val14Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TAS2R31 p.Asn112Tyr Uncertain significance Single submitter
- TAS2R31 p.Leu279Pro Uncertain significance Single submitter
- TAS2R31 p.Leu286Val Uncertain significance Single submitter
- TAS2R31 p.Pro136Thr Uncertain significance Single submitter
- TAS2R31 p.Pro187Ser Uncertain significance Single submitter
- TAS2R31 p.Pro272Leu Uncertain significance Single submitter
- TAS2R31 p.Pro276Ala Likely benign Single submitter
- TAS2R31 p.Val12Glu Uncertain significance Single submitter
- TAS2R31 p.Val172Ala Uncertain significance Single submitter
All TAS2R31 variants
Likely benign 4
- p.Ala84Val Single submitter
- p.Ile166Thr Single submitter
- p.Pro276Ala Single submitter ⚠
- p.Thr289Ala Single submitter
Uncertain significance 41
- p.Ala266Gly Single submitter ⚠
- p.Ala266Val Single submitter ⚠
- p.Arg295Gln Single submitter ⚠
- p.Arg35Gln Single submitter ⚠
- p.Asn112Tyr Single submitter ⚠
- p.Asn161Lys Single submitter ⚠
- p.Asn283Asp Single submitter ⚠
- p.Asn86Ser Single submitter ⚠
- p.Ile19Thr Single submitter ⚠
- p.Ile267Val Single submitter ⚠
- p.Ile280Met Single submitter ⚠
- p.Ile41Phe Single submitter ⚠
- p.Ile8Val Single submitter ⚠
- p.Leu185Val Single submitter ⚠
- p.Leu279Pro Single submitter ⚠
- p.Leu286Val Single submitter ⚠
- p.Leu62Val Single submitter ⚠
- p.Lys126Arg Single submitter ⚠
- p.Lys265Asn Single submitter ⚠
- p.Lys284Glu Single submitter ⚠
- p.Met149Thr Single submitter ⚠
- p.Pro136Thr Single submitter ⚠
- p.Pro187Ser Single submitter ⚠
- p.Pro272Leu Single submitter ⚠
- p.Pro309Leu Single submitter ⚠
- p.Ser101Thr Single submitter ⚠
- p.Ser127Arg Single submitter ⚠
- p.Thr100Ala Single submitter ⚠
- p.Thr155Lys Single submitter ⚠
- p.Thr163Ile Single submitter ⚠
- p.Thr230Ile Single submitter ⚠
- p.Thr289Ser Single submitter ⚠
- p.Thr83Asn Single submitter ⚠
- p.Tyr76Asn Single submitter ⚠
- p.Tyr76His Single submitter ⚠
- p.Tyr85Cys Single submitter ⚠
- p.Val125Ile Single submitter ⚠
- p.Val12Glu Single submitter ⚠
- p.Val13Ile Single submitter ⚠
- p.Val14Met Single submitter ⚠
- p.Val172Ala Single submitter ⚠