TAS2R38 — 59 ClinVar variants
All ClinVar germline TAS2R38 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 53 flagged for review →
1 Benign · 4 Likely benign · 54 Uncertain significance
Full TAS2R38 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 53
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 47
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R38 p.Arg222Lys Uncertain significance Single submitter
- TAS2R38 p.Arg232Gly Uncertain significance Single submitter
- TAS2R38 p.Arg235His Uncertain significance Single submitter
- TAS2R38 p.Arg330Gln Uncertain significance Single submitter
- TAS2R38 p.Arg330Pro Uncertain significance Single submitter
- TAS2R38 p.Arg6Cys Uncertain significance Single submitter
- TAS2R38 p.Arg8His Uncertain significance Single submitter
- TAS2R38 p.Arg8Leu Uncertain significance Single submitter
- TAS2R38 p.Asn177Asp Uncertain significance Single submitter
- TAS2R38 p.Asn177Ser Uncertain significance Single submitter
- TAS2R38 p.Asp324Asn Uncertain significance Single submitter
- TAS2R38 p.Cys152Gly Uncertain significance Single submitter
- TAS2R38 p.Cys152Tyr Uncertain significance Single submitter
- TAS2R38 p.Gln185Glu Uncertain significance Single submitter
- TAS2R38 p.Gly29Ala Uncertain significance Single submitter
- TAS2R38 p.His90Asp Uncertain significance Single submitter
- TAS2R38 p.Ile101Phe Uncertain significance Single submitter
- TAS2R38 p.Ile140Ser Uncertain significance Single submitter
- TAS2R38 p.Ile153Asn Uncertain significance Single submitter
- TAS2R38 p.Ile243Val Uncertain significance Single submitter
- TAS2R38 p.Leu113Phe Uncertain significance Single submitter
- TAS2R38 p.Leu157Phe Uncertain significance Single submitter
- TAS2R38 p.Leu38Phe Uncertain significance Single submitter
- TAS2R38 p.Leu4Pro Uncertain significance Single submitter
- TAS2R38 p.Lys139Asn Uncertain significance Single submitter
- TAS2R38 p.Lys187Glu Uncertain significance Single submitter
- TAS2R38 p.Lys320Asn Uncertain significance Single submitter
- TAS2R38 p.Met215Ile Uncertain significance Single submitter
- TAS2R38 p.Met97Ile Uncertain significance Single submitter
- TAS2R38 p.Phe163Leu Uncertain significance Single submitter
- TAS2R38 p.Phe255Ser Uncertain significance Single submitter
- TAS2R38 p.Pro237Leu Uncertain significance Single submitter
- TAS2R38 p.Ser164Arg Uncertain significance Single submitter
- TAS2R38 p.Ser234Ala Uncertain significance Single submitter
- TAS2R38 p.Ser329Cys Uncertain significance Single submitter
- TAS2R38 p.Ser51Gly Uncertain significance Single submitter
- TAS2R38 p.Ser74Thr Uncertain significance Single submitter
- TAS2R38 p.Thr155Ile Uncertain significance Single submitter
- TAS2R38 p.Trp314Ser Uncertain significance Single submitter
- TAS2R38 p.Tyr12Cys Uncertain significance Single submitter
- TAS2R38 p.Val10Ala Uncertain significance Single submitter
- TAS2R38 p.Val156Ala Uncertain significance Single submitter
- TAS2R38 p.Val211Phe Uncertain significance Single submitter
- TAS2R38 p.Val257Met Uncertain significance Single submitter
- TAS2R38 p.Val279Glu Uncertain significance Single submitter
- TAS2R38 p.Val308Leu Uncertain significance Single submitter
- TAS2R38 p.Val45Met Uncertain significance Single submitter
Predictors split 6
The independent predictors disagree with each other — read with care.
- TAS2R38 p.Ala111Asp Uncertain significance Single submitter
- TAS2R38 p.Arg64Trp Uncertain significance Single submitter
- TAS2R38 p.Leu88Arg Uncertain significance Single submitter
- TAS2R38 p.Pro268Arg Uncertain significance Single submitter
- TAS2R38 p.Ser11Phe Uncertain significance Single submitter
- TAS2R38 p.Thr217Pro Uncertain significance Single submitter
All TAS2R38 variants
Benign 1
- p.Ala262= Single submitter
Likely benign 4
- p.Ala315= Single submitter
- p.Asn106Ser Single submitter
- p.Asp275Asn Single submitter
- p.Leu182Phe Single submitter
Uncertain significance 54
- p.Ala111Asp Single submitter ⚠
- p.Arg222Lys Single submitter ⚠
- p.Arg232Gly Single submitter ⚠
- p.Arg235His Single submitter ⚠
- p.Arg330Gln Single submitter ⚠
- p.Arg330Pro Single submitter ⚠
- p.Arg64Trp Single submitter ⚠
- p.Arg6Cys Single submitter ⚠
- p.Arg8His Single submitter ⚠
- p.Arg8Leu Single submitter ⚠
- p.Asn177Asp Single submitter ⚠
- p.Asn177Ser Single submitter ⚠
- p.Asp324Asn Single submitter ⚠
- p.Cys152Gly Single submitter ⚠
- p.Cys152Tyr Single submitter ⚠
- p.Gln185Glu Single submitter ⚠
- p.Gly29Ala Single submitter ⚠
- p.His223Gln Single submitter
- p.His90Asp Single submitter ⚠
- p.Ile101Phe Single submitter ⚠
- p.Ile140Ser Single submitter ⚠
- p.Ile153Asn Single submitter ⚠
- p.Ile243Val Single submitter ⚠
- p.Leu113Phe Single submitter ⚠
- p.Leu157Phe Single submitter ⚠
- p.Leu38Phe Single submitter ⚠
- p.Leu4Pro Single submitter ⚠
- p.Leu88Arg Single submitter ⚠
- p.Lys139Asn Single submitter ⚠
- p.Lys187Glu Single submitter ⚠
- p.Lys320Asn Single submitter ⚠
- p.Met215Ile Single submitter ⚠
- p.Met97Ile Single submitter ⚠
- p.Phe163Leu Single submitter ⚠
- p.Phe255Ser Single submitter ⚠
- p.Pro237Leu Single submitter ⚠
- p.Pro268Arg Single submitter ⚠
- p.Ser11Phe Single submitter ⚠
- p.Ser164Arg Single submitter ⚠
- p.Ser234Ala Single submitter ⚠
- p.Ser329Cys Single submitter ⚠
- p.Ser51Gly Single submitter ⚠
- p.Ser74Thr Single submitter ⚠
- p.Thr155Ile Single submitter ⚠
- p.Thr217Pro Single submitter ⚠
- p.Trp314Ser Single submitter ⚠
- p.Tyr12Cys Single submitter ⚠
- p.Val10Ala Single submitter ⚠
- p.Val156Ala Single submitter ⚠
- p.Val211Phe Single submitter ⚠
- p.Val257Met Single submitter ⚠
- p.Val279Glu Single submitter ⚠
- p.Val308Leu Single submitter ⚠
- p.Val45Met Single submitter ⚠