TAS2R39 — 52 ClinVar variants
All ClinVar germline TAS2R39 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 45 flagged for review →
7 Likely benign · 45 Uncertain significance
Full TAS2R39 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 45
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 37
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R39 p.Ala140Val Uncertain significance Single submitter
- TAS2R39 p.Ala277Val Uncertain significance Single submitter
- TAS2R39 p.Ala302Val Uncertain significance Single submitter
- TAS2R39 p.Ala61Thr Uncertain significance Single submitter
- TAS2R39 p.Arg153Ile Uncertain significance Single submitter
- TAS2R39 p.Arg324Trp Uncertain significance Single submitter
- TAS2R39 p.Arg4Ser Uncertain significance Single submitter
- TAS2R39 p.Asn250Ser Uncertain significance Single submitter
- TAS2R39 p.Asn293Tyr Uncertain significance Single submitter
- TAS2R39 p.Asn315Lys Uncertain significance Single submitter
- TAS2R39 p.Asp251Asn Uncertain significance Single submitter
- TAS2R39 p.Cys123Phe Uncertain significance Single submitter
- TAS2R39 p.Cys184Arg Uncertain significance Single submitter
- TAS2R39 p.Cys184Tyr Uncertain significance Single submitter
- TAS2R39 p.Gln313Glu Uncertain significance Single submitter
- TAS2R39 p.Gly208Cys Uncertain significance Single submitter
- TAS2R39 p.Ile154Val Uncertain significance Single submitter
- TAS2R39 p.Ile190Met Uncertain significance Single submitter
- TAS2R39 p.Ile204Phe Uncertain significance Single submitter
- TAS2R39 p.Ile261Thr Uncertain significance Single submitter
- TAS2R39 p.Ile50Thr Uncertain significance Single submitter
- TAS2R39 p.Leu21Phe Uncertain significance Single submitter
- TAS2R39 p.Leu240Val Uncertain significance Single submitter
- TAS2R39 p.Leu270Phe Uncertain significance Single submitter
- TAS2R39 p.Leu38Val Uncertain significance Single submitter
- TAS2R39 p.Met174Arg Uncertain significance Single submitter
- TAS2R39 p.Met90Val Uncertain significance Single submitter
- TAS2R39 p.Phe167Ile Uncertain significance Single submitter
- TAS2R39 p.Phe32Leu Uncertain significance Single submitter
- TAS2R39 p.Pro24Thr Uncertain significance Single submitter
- TAS2R39 p.Ser171Ile Uncertain significance Single submitter
- TAS2R39 p.Ser187Thr Uncertain significance Single submitter
- TAS2R39 p.Ser244Arg Uncertain significance Single submitter
- TAS2R39 p.Ser290Gly Uncertain significance Single submitter
- TAS2R39 p.Thr99Ala Uncertain significance Single submitter
- TAS2R39 p.Tyr135Cys Uncertain significance Single submitter
- TAS2R39 p.Val218Leu Uncertain significance Single submitter
Predictors split 8
The independent predictors disagree with each other — read with care.
- TAS2R39 p.Ala129Pro Uncertain significance Single submitter
- TAS2R39 p.His257Asp Uncertain significance Single submitter
- TAS2R39 p.His307Gln Uncertain significance Single submitter
- TAS2R39 p.Ile154Asn Uncertain significance Single submitter
- TAS2R39 p.Met223Lys Uncertain significance Single submitter
- TAS2R39 p.Phe113Leu Uncertain significance Single submitter
- TAS2R39 p.Ser124Arg Uncertain significance Single submitter
- TAS2R39 p.Ser171Arg Uncertain significance Single submitter
All TAS2R39 variants
Likely benign 7
- p.Ala210Val Single submitter
- p.Arg324Gln Single submitter
- p.Asp23Asn Single submitter
- p.Gly208Ser Single submitter
- p.Ile309Val Single submitter
- p.Leu233Ile Single submitter
- p.Met56Thr Single submitter
Uncertain significance 45
- p.Ala129Pro Single submitter ⚠
- p.Ala140Val Single submitter ⚠
- p.Ala277Val Single submitter ⚠
- p.Ala302Val Single submitter ⚠
- p.Ala61Thr Single submitter ⚠
- p.Arg153Ile Single submitter ⚠
- p.Arg324Trp Single submitter ⚠
- p.Arg4Ser Single submitter ⚠
- p.Asn250Ser Single submitter ⚠
- p.Asn293Tyr Single submitter ⚠
- p.Asn315Lys Single submitter ⚠
- p.Asp251Asn Single submitter ⚠
- p.Cys123Phe Single submitter ⚠
- p.Cys184Arg Single submitter ⚠
- p.Cys184Tyr Single submitter ⚠
- p.Gln313Glu Single submitter ⚠
- p.Gly208Cys Single submitter ⚠
- p.His257Asp Single submitter ⚠
- p.His307Gln Single submitter ⚠
- p.Ile154Asn Single submitter ⚠
- p.Ile154Val Single submitter ⚠
- p.Ile190Met Single submitter ⚠
- p.Ile204Phe Single submitter ⚠
- p.Ile261Thr Single submitter ⚠
- p.Ile50Thr Single submitter ⚠
- p.Leu21Phe Single submitter ⚠
- p.Leu240Val Single submitter ⚠
- p.Leu270Phe Single submitter ⚠
- p.Leu38Val Single submitter ⚠
- p.Met174Arg Single submitter ⚠
- p.Met223Lys Single submitter ⚠
- p.Met90Val Single submitter ⚠
- p.Phe113Leu Single submitter ⚠
- p.Phe167Ile Single submitter ⚠
- p.Phe32Leu Single submitter ⚠
- p.Pro24Thr Single submitter ⚠
- p.Ser124Arg Single submitter ⚠
- p.Ser171Arg Single submitter ⚠
- p.Ser171Ile Single submitter ⚠
- p.Ser187Thr Single submitter ⚠
- p.Ser244Arg Single submitter ⚠
- p.Ser290Gly Single submitter ⚠
- p.Thr99Ala Single submitter ⚠
- p.Tyr135Cys Single submitter ⚠
- p.Val218Leu Single submitter ⚠