TAS2R4 — 48 ClinVar variants
All ClinVar germline TAS2R4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
2 Benign · 9 Likely benign · 37 Uncertain significance
Full TAS2R4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R4 p.Asn213Ser Uncertain significance Single submitter
- TAS2R4 p.Cys145Ser Uncertain significance Single submitter
- TAS2R4 p.Cys296Arg Uncertain significance Single submitter
- TAS2R4 p.Cys296Phe Uncertain significance Single submitter
- TAS2R4 p.Gln249Arg Uncertain significance Single submitter
- TAS2R4 p.His201Gln Uncertain significance Single submitter
- TAS2R4 p.His39Arg Uncertain significance Single submitter
- TAS2R4 p.Ile15Val Uncertain significance Single submitter
- TAS2R4 p.Ile207Thr Uncertain significance Single submitter
- TAS2R4 p.Ile240Val Uncertain significance Single submitter
- TAS2R4 p.Ile280Val Uncertain significance Single submitter
- TAS2R4 p.Ile67Thr Uncertain significance Single submitter
- TAS2R4 p.Ile67Val Uncertain significance Single submitter
- TAS2R4 p.Leu159Val Uncertain significance Single submitter
- TAS2R4 p.Leu25Pro Uncertain significance Single submitter
- TAS2R4 p.Lys262Thr Uncertain significance Single submitter
- TAS2R4 p.Met229Thr Uncertain significance Single submitter
- TAS2R4 p.Met229Val Uncertain significance Single submitter
- TAS2R4 p.Met23Thr Uncertain significance Single submitter
- TAS2R4 p.Met257Lys Uncertain significance Single submitter
- TAS2R4 p.Met89Ile Uncertain significance Single submitter
- TAS2R4 p.Phe217Ser Uncertain significance Single submitter
- TAS2R4 p.Phe90Ile Uncertain significance Single submitter
- TAS2R4 p.Phe98Ile Uncertain significance Single submitter
- TAS2R4 p.Pro155Leu Uncertain significance Single submitter
- TAS2R4 p.Ser277Tyr Uncertain significance Single submitter
- TAS2R4 p.Ser77Thr Uncertain significance Single submitter
- TAS2R4 p.Ser93Leu Uncertain significance Single submitter
- TAS2R4 p.Thr149Met Uncertain significance Single submitter
- TAS2R4 p.Thr162Met Uncertain significance Single submitter
- TAS2R4 p.Thr283Ile Uncertain significance Single submitter
- TAS2R4 p.Val117Met Uncertain significance Single submitter
- TAS2R4 p.Val78Phe Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R4 variants
Likely benign 9
- p.Thr222Met Multiple submitters
- p.Ala269= Single submitter
- p.Arg3Trp Single submitter
- p.Asn31Ser Single submitter
- p.Ile148Val Single submitter
- p.Phe62Leu Single submitter ⚠
- p.Phe69= Single submitter
- p.Thr162Lys Single submitter
- p.Val64Leu Single submitter
Uncertain significance 37
- p.Asn213Ser Single submitter ⚠
- p.Cys145Ser Single submitter ⚠
- p.Cys296Arg Single submitter ⚠
- p.Cys296Phe Single submitter ⚠
- p.Gln249Arg Single submitter ⚠
- p.Glu223Gly Single submitter ⚠
- p.Gly173Cys Single submitter ⚠
- p.His201Gln Single submitter ⚠
- p.His39Arg Single submitter ⚠
- p.Ile15Val Single submitter ⚠
- p.Ile207Thr Single submitter ⚠
- p.Ile240Val Single submitter ⚠
- p.Ile280Val Single submitter ⚠
- p.Ile67Thr Single submitter ⚠
- p.Ile67Val Single submitter ⚠
- p.Leu159Val Single submitter ⚠
- p.Leu25Pro Single submitter ⚠
- p.Lys262Thr Single submitter ⚠
- p.Met229Thr Single submitter ⚠
- p.Met229Val Single submitter ⚠
- p.Met23Thr Single submitter ⚠
- p.Met257Lys Single submitter ⚠
- p.Met89Ile Single submitter ⚠
- p.Phe217Ser Single submitter ⚠
- p.Phe90Ile Single submitter ⚠
- p.Phe98Ile Single submitter ⚠
- p.Pro155Leu Single submitter ⚠
- p.Ser277Tyr Single submitter ⚠
- p.Ser77Thr Single submitter ⚠
- p.Ser93Leu Single submitter ⚠
- p.Thr149Met Single submitter ⚠
- p.Thr162Met Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Thr283Ile Single submitter ⚠
- p.Tyr6Cys Single submitter ⚠
- p.Val117Met Single submitter ⚠
- p.Val78Phe Single submitter ⚠