TAS2R40 — 43 ClinVar variants
All ClinVar germline TAS2R40 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
4 Likely benign · 39 Uncertain significance
Full TAS2R40 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R40 p.Ala231Asp Uncertain significance Single submitter
- TAS2R40 p.Ala262Thr Uncertain significance Single submitter
- TAS2R40 p.Arg136Lys Uncertain significance Single submitter
- TAS2R40 p.Arg309Gln Uncertain significance Single submitter
- TAS2R40 p.Asn127Ser Uncertain significance Single submitter
- TAS2R40 p.Asn190Ser Uncertain significance Single submitter
- TAS2R40 p.Asn269Thr Uncertain significance Single submitter
- TAS2R40 p.Cys120Phe Uncertain significance Single submitter
- TAS2R40 p.Gly201Glu Uncertain significance Single submitter
- TAS2R40 p.Gly244Arg Uncertain significance Single submitter
- TAS2R40 p.Gly35Ala Uncertain significance Single submitter
- TAS2R40 p.Gly56Asp Uncertain significance Single submitter
- TAS2R40 p.Ile100Thr Uncertain significance Single submitter
- TAS2R40 p.Ile139Thr Uncertain significance Single submitter
- TAS2R40 p.Ile246Met Uncertain significance Single submitter
- TAS2R40 p.Ile283Met Uncertain significance Single submitter
- TAS2R40 p.Lys137Asn Uncertain significance Single submitter
- TAS2R40 p.Lys183Asn Uncertain significance Single submitter
- TAS2R40 p.Phe158Val Uncertain significance Single submitter
- TAS2R40 p.Phe197Ser Uncertain significance Single submitter
- TAS2R40 p.Pro205Ser Uncertain significance Single submitter
- TAS2R40 p.Pro301Ser Uncertain significance Single submitter
- TAS2R40 p.Ser275Thr Uncertain significance Single submitter
- TAS2R40 p.Ser276Pro Uncertain significance Single submitter
- TAS2R40 p.Thr224Ile Uncertain significance Single submitter
- TAS2R40 p.Thr40Met Uncertain significance Single submitter
- TAS2R40 p.Trp114Arg Uncertain significance Single submitter
- TAS2R40 p.Tyr119Asn Uncertain significance Single submitter
- TAS2R40 p.Tyr288Ser Uncertain significance Single submitter
- TAS2R40 p.Tyr43Cys Uncertain significance Single submitter
- TAS2R40 p.Val23Met Uncertain significance Single submitter
- TAS2R40 p.Val314Ala Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TAS2R40 p.Gly26Arg Uncertain significance Multiple submitters
- TAS2R40 p.Ala113Val Uncertain significance Single submitter
- TAS2R40 p.Gly32Ser Uncertain significance Single submitter
- TAS2R40 p.Gly50Ser Uncertain significance Single submitter
- TAS2R40 p.Phe38Ser Uncertain significance Single submitter
- TAS2R40 p.Pro289Ala Uncertain significance Single submitter
- TAS2R40 p.Val204Asp Uncertain significance Single submitter
All TAS2R40 variants
Likely benign 4
- p.Arg162Lys Single submitter
- p.Arg58Cys Single submitter
- p.Gln295Leu Single submitter
- p.Val164Ile Single submitter
Uncertain significance 39
- p.Gly26Arg Multiple submitters ⚠
- p.Ala113Val Single submitter ⚠
- p.Ala231Asp Single submitter ⚠
- p.Ala262Thr Single submitter ⚠
- p.Arg136Lys Single submitter ⚠
- p.Arg309Gln Single submitter ⚠
- p.Asn127Ser Single submitter ⚠
- p.Asn190Ser Single submitter ⚠
- p.Asn269Thr Single submitter ⚠
- p.Cys120Phe Single submitter ⚠
- p.Gly201Glu Single submitter ⚠
- p.Gly244Arg Single submitter ⚠
- p.Gly32Ser Single submitter ⚠
- p.Gly35Ala Single submitter ⚠
- p.Gly50Ser Single submitter ⚠
- p.Gly56Asp Single submitter ⚠
- p.Ile100Thr Single submitter ⚠
- p.Ile139Thr Single submitter ⚠
- p.Ile246Met Single submitter ⚠
- p.Ile283Met Single submitter ⚠
- p.Lys137Asn Single submitter ⚠
- p.Lys183Asn Single submitter ⚠
- p.Phe158Val Single submitter ⚠
- p.Phe197Ser Single submitter ⚠
- p.Phe38Ser Single submitter ⚠
- p.Pro205Ser Single submitter ⚠
- p.Pro289Ala Single submitter ⚠
- p.Pro301Ser Single submitter ⚠
- p.Ser275Thr Single submitter ⚠
- p.Ser276Pro Single submitter ⚠
- p.Thr224Ile Single submitter ⚠
- p.Thr40Met Single submitter ⚠
- p.Trp114Arg Single submitter ⚠
- p.Tyr119Asn Single submitter ⚠
- p.Tyr288Ser Single submitter ⚠
- p.Tyr43Cys Single submitter ⚠
- p.Val204Asp Single submitter ⚠
- p.Val23Met Single submitter ⚠
- p.Val314Ala Single submitter ⚠