TAS2R43 — 48 ClinVar variants
All ClinVar germline TAS2R43 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 37 flagged for review →
4 Benign · 7 Likely benign · 37 Uncertain significance
Full TAS2R43 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 37
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R43 p.Ala141Thr Uncertain significance Single submitter
- TAS2R43 p.Arg124Ser Uncertain significance Single submitter
- TAS2R43 p.Arg268Ile Uncertain significance Single submitter
- TAS2R43 p.Asn148Lys Uncertain significance Single submitter
- TAS2R43 p.Asn283Lys Uncertain significance Single submitter
- TAS2R43 p.Cys142Ser Uncertain significance Single submitter
- TAS2R43 p.Gln288Arg Uncertain significance Single submitter
- TAS2R43 p.Gly213Asp Uncertain significance Single submitter
- TAS2R43 p.Gly213Val Uncertain significance Single submitter
- TAS2R43 p.Ile110Val Uncertain significance Single submitter
- TAS2R43 p.Ile247Met Uncertain significance Single submitter
- TAS2R43 p.Ile247Thr Uncertain significance Single submitter
- TAS2R43 p.Ile278Val Uncertain significance Single submitter
- TAS2R43 p.Ile27Val Uncertain significance Single submitter
- TAS2R43 p.Leu12Val Uncertain significance Single submitter
- TAS2R43 p.Leu168Trp Uncertain significance Single submitter
- TAS2R43 p.Leu63Val Uncertain significance Single submitter
- TAS2R43 p.Lys207Asn Uncertain significance Single submitter
- TAS2R43 p.Lys40Arg Uncertain significance Single submitter
- TAS2R43 p.Met177Ile Uncertain significance Single submitter
- TAS2R43 p.Met181Val Uncertain significance Single submitter
- TAS2R43 p.Phe269Ser Uncertain significance Single submitter
- TAS2R43 p.Ser270Cys Uncertain significance Single submitter
- TAS2R43 p.Ser307Ala Uncertain significance Single submitter
- TAS2R43 p.Thr221Ile Uncertain significance Single submitter
- TAS2R43 p.Thr230Ser Uncertain significance Single submitter
- TAS2R43 p.Thr83Ala Uncertain significance Single submitter
- TAS2R43 p.Trp281Cys Uncertain significance Single submitter
- TAS2R43 p.Val15Leu Uncertain significance Single submitter
- TAS2R43 p.Val70Leu Uncertain significance Single submitter
- TAS2R43 p.Val78Ala Uncertain significance Single submitter
- TAS2R43 p.Val90Met Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TAS2R43 variants
Benign 4
- p.Phe36Val Multiple submitters
- p.Leu12= Single submitter
- p.Leu29= Single submitter
- p.Leu5= Single submitter
Likely benign 7
- p.Thr221= Multiple submitters
- p.Arg154Gln Single submitter
- p.Asn76Ser Single submitter
- p.Ile152= Single submitter
- p.Leu71Phe Single submitter
- p.Ser11Ile Single submitter
- p.Val131Met Single submitter
Uncertain significance 37
- p.Ala141Thr Single submitter ⚠
- p.Arg124Ser Single submitter ⚠
- p.Arg268Ile Single submitter ⚠
- p.Asn148Lys Single submitter ⚠
- p.Asn283Lys Single submitter ⚠
- p.Cys142Ser Single submitter ⚠
- p.Gln288Arg Single submitter ⚠
- p.Gly135Arg Single submitter ⚠
- p.Gly213Asp Single submitter ⚠
- p.Gly213Val Single submitter ⚠
- p.His93Arg Single submitter ⚠
- p.Ile110Val Single submitter ⚠
- p.Ile247Met Single submitter ⚠
- p.Ile247Thr Single submitter ⚠
- p.Ile278Val Single submitter ⚠
- p.Ile27Val Single submitter ⚠
- p.Leu12Val Single submitter ⚠
- p.Leu168Trp Single submitter ⚠
- p.Leu63Val Single submitter ⚠
- p.Leu98Val Single submitter ⚠
- p.Lys207Asn Single submitter ⚠
- p.Lys40Arg Single submitter ⚠
- p.Met177Ile Single submitter ⚠
- p.Met181Val Single submitter ⚠
- p.Phe269Ser Single submitter ⚠
- p.Ser270Cys Single submitter ⚠
- p.Ser307Ala Single submitter ⚠
- p.Thr221Ile Single submitter ⚠
- p.Thr230Ser Single submitter ⚠
- p.Thr83Ala Single submitter ⚠
- p.Trp281Cys Single submitter ⚠
- p.Trp60Arg Single submitter ⚠
- p.Trp66Arg Single submitter ⚠
- p.Val15Leu Single submitter ⚠
- p.Val70Leu Single submitter ⚠
- p.Val78Ala Single submitter ⚠
- p.Val90Met Single submitter ⚠