TAS2R46 — 52 ClinVar variants
All ClinVar germline TAS2R46 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
6 Likely benign · 46 Uncertain significance
Full TAS2R46 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 34
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R46 p.Arg169Ser Uncertain significance Single submitter
- TAS2R46 p.Arg169Trp Uncertain significance Single submitter
- TAS2R46 p.Arg298Ser Uncertain significance Single submitter
- TAS2R46 p.Asn76Ile Uncertain significance Single submitter
- TAS2R46 p.Gln46His Uncertain significance Single submitter
- TAS2R46 p.Ile104Met Uncertain significance Single submitter
- TAS2R46 p.Ile193Val Uncertain significance Single submitter
- TAS2R46 p.Ile33Thr Uncertain significance Single submitter
- TAS2R46 p.Ile91Val Uncertain significance Single submitter
- TAS2R46 p.Leu137Ser Uncertain significance Single submitter
- TAS2R46 p.Leu29Met Uncertain significance Single submitter
- TAS2R46 p.Leu29Ser Uncertain significance Single submitter
- TAS2R46 p.Leu98Phe Uncertain significance Single submitter
- TAS2R46 p.Lys167Gln Uncertain significance Single submitter
- TAS2R46 p.Lys258Gln Uncertain significance Single submitter
- TAS2R46 p.Lys305Arg Uncertain significance Single submitter
- TAS2R46 p.Lys37Arg Uncertain significance Single submitter
- TAS2R46 p.Met209Thr Uncertain significance Single submitter
- TAS2R46 p.Met221Val Uncertain significance Single submitter
- TAS2R46 p.Phe36Leu Uncertain significance Single submitter
- TAS2R46 p.Pro6Ser Uncertain significance Single submitter
- TAS2R46 p.Pro73Ser Uncertain significance Single submitter
- TAS2R46 p.Ser101Gly Uncertain significance Single submitter
- TAS2R46 p.Ser10Tyr Uncertain significance Single submitter
- TAS2R46 p.Ser127Gly Uncertain significance Single submitter
- TAS2R46 p.Ser216Phe Uncertain significance Single submitter
- TAS2R46 p.Ser233Phe Uncertain significance Single submitter
- TAS2R46 p.Ser308Pro Uncertain significance Single submitter
- TAS2R46 p.Thr178Met Uncertain significance Single submitter
- TAS2R46 p.Thr232Ser Uncertain significance Single submitter
- TAS2R46 p.Thr274Ile Uncertain significance Single submitter
- TAS2R46 p.Thr83Ile Uncertain significance Single submitter
- TAS2R46 p.Val249Ile Uncertain significance Single submitter
- TAS2R46 p.Val61Leu Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TAS2R46 p.Ala268Pro Uncertain significance Single submitter
- TAS2R46 p.Ala99Pro Uncertain significance Single submitter
- TAS2R46 p.Asn24His Uncertain significance Single submitter
- TAS2R46 p.Gly282Val Uncertain significance Single submitter
- TAS2R46 p.Gly57Asp Uncertain significance Single submitter
- TAS2R46 p.Leu198Phe Uncertain significance Single submitter
- TAS2R46 p.Pro272Thr Uncertain significance Single submitter
- TAS2R46 p.Ser194Pro Uncertain significance Single submitter
- TAS2R46 p.Ser194Tyr Uncertain significance Single submitter
- TAS2R46 p.Trp66Cys Uncertain significance Single submitter
- TAS2R46 p.Trp97Arg Uncertain significance Single submitter
- TAS2R46 p.Val223Phe Uncertain significance Single submitter
All TAS2R46 variants
Likely benign 6
Uncertain significance 46
- p.Ala268Pro Single submitter ⚠
- p.Ala99Pro Single submitter ⚠
- p.Arg169Ser Single submitter ⚠
- p.Arg169Trp Single submitter ⚠
- p.Arg298Ser Single submitter ⚠
- p.Asn24His Single submitter ⚠
- p.Asn76Ile Single submitter ⚠
- p.Gln46His Single submitter ⚠
- p.Gly282Val Single submitter ⚠
- p.Gly57Asp Single submitter ⚠
- p.Ile104Met Single submitter ⚠
- p.Ile193Val Single submitter ⚠
- p.Ile33Thr Single submitter ⚠
- p.Ile91Val Single submitter ⚠
- p.Leu137Ser Single submitter ⚠
- p.Leu198Phe Single submitter ⚠
- p.Leu29Met Single submitter ⚠
- p.Leu29Ser Single submitter ⚠
- p.Leu98Phe Single submitter ⚠
- p.Lys167Gln Single submitter ⚠
- p.Lys258Gln Single submitter ⚠
- p.Lys305Arg Single submitter ⚠
- p.Lys37Arg Single submitter ⚠
- p.Met209Thr Single submitter ⚠
- p.Met221Val Single submitter ⚠
- p.Phe36Leu Single submitter ⚠
- p.Pro272Thr Single submitter ⚠
- p.Pro6Ser Single submitter ⚠
- p.Pro73Ser Single submitter ⚠
- p.Ser101Gly Single submitter ⚠
- p.Ser10Tyr Single submitter ⚠
- p.Ser127Gly Single submitter ⚠
- p.Ser194Pro Single submitter ⚠
- p.Ser194Tyr Single submitter ⚠
- p.Ser216Phe Single submitter ⚠
- p.Ser233Phe Single submitter ⚠
- p.Ser308Pro Single submitter ⚠
- p.Thr178Met Single submitter ⚠
- p.Thr232Ser Single submitter ⚠
- p.Thr274Ile Single submitter ⚠
- p.Thr83Ile Single submitter ⚠
- p.Trp66Cys Single submitter ⚠
- p.Trp97Arg Single submitter ⚠
- p.Val223Phe Single submitter ⚠
- p.Val249Ile Single submitter ⚠
- p.Val61Leu Single submitter ⚠