TAS2R8 — 44 ClinVar variants
All ClinVar germline TAS2R8 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
1 Benign · 5 Likely benign · 38 Uncertain significance
Full TAS2R8 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 31
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R8 p.Ala148Gly Uncertain significance Single submitter
- TAS2R8 p.Ala190Ser Uncertain significance Single submitter
- TAS2R8 p.Ala306Val Uncertain significance Single submitter
- TAS2R8 p.Asn93Ser Uncertain significance Single submitter
- TAS2R8 p.Gln81Lys Uncertain significance Single submitter
- TAS2R8 p.Gln82His Uncertain significance Single submitter
- TAS2R8 p.Glu271Lys Uncertain significance Single submitter
- TAS2R8 p.Gly136Ala Uncertain significance Single submitter
- TAS2R8 p.His159Arg Uncertain significance Single submitter
- TAS2R8 p.His159Tyr Uncertain significance Single submitter
- TAS2R8 p.Ile177Val Uncertain significance Single submitter
- TAS2R8 p.Ile252Met Uncertain significance Single submitter
- TAS2R8 p.Ile286Thr Uncertain significance Single submitter
- TAS2R8 p.Ile305Met Uncertain significance Single submitter
- TAS2R8 p.Ile59Phe Uncertain significance Single submitter
- TAS2R8 p.Leu118Phe Uncertain significance Single submitter
- TAS2R8 p.Leu143Ser Uncertain significance Single submitter
- TAS2R8 p.Leu19Val Uncertain significance Single submitter
- TAS2R8 p.Leu217Phe Uncertain significance Single submitter
- TAS2R8 p.Lys165Glu Uncertain significance Single submitter
- TAS2R8 p.Lys176Ile Uncertain significance Single submitter
- TAS2R8 p.Met237Thr Uncertain significance Single submitter
- TAS2R8 p.Met62Val Uncertain significance Single submitter
- TAS2R8 p.Met97Ile Uncertain significance Single submitter
- TAS2R8 p.Pro178Ser Uncertain significance Single submitter
- TAS2R8 p.Thr101Ser Uncertain significance Single submitter
- TAS2R8 p.Thr184Ile Uncertain significance Single submitter
- TAS2R8 p.Thr227Lys Uncertain significance Single submitter
- TAS2R8 p.Thr77Ile Uncertain significance Single submitter
- TAS2R8 p.Val151Ile Uncertain significance Single submitter
- TAS2R8 p.Val64Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TAS2R8 p.Arg210Ile Uncertain significance Single submitter
- TAS2R8 p.His281Tyr Uncertain significance Single submitter
- TAS2R8 p.Leu118Pro Uncertain significance Single submitter
- TAS2R8 p.Lys39Thr Uncertain significance Single submitter
- TAS2R8 p.Phe119Ser Uncertain significance Single submitter
- TAS2R8 p.Phe186Leu Uncertain significance Single submitter
- TAS2R8 p.Ser200Pro Uncertain significance Single submitter
All TAS2R8 variants
Benign 1
- p.Glu16Ter Single submitter
Likely benign 5
- p.Ala92Thr Single submitter
- p.Gly221Ser Single submitter
- p.Ile168Val Single submitter
- p.Phe189Leu Single submitter
- p.Trp124Arg Single submitter
Uncertain significance 38
- p.Ala148Gly Single submitter ⚠
- p.Ala190Ser Single submitter ⚠
- p.Ala306Val Single submitter ⚠
- p.Arg210Ile Single submitter ⚠
- p.Asn93Ser Single submitter ⚠
- p.Gln81Lys Single submitter ⚠
- p.Gln82His Single submitter ⚠
- p.Glu271Lys Single submitter ⚠
- p.Gly136Ala Single submitter ⚠
- p.His159Arg Single submitter ⚠
- p.His159Tyr Single submitter ⚠
- p.His281Tyr Single submitter ⚠
- p.Ile177Val Single submitter ⚠
- p.Ile252Met Single submitter ⚠
- p.Ile286Thr Single submitter ⚠
- p.Ile305Met Single submitter ⚠
- p.Ile59Phe Single submitter ⚠
- p.Leu118Phe Single submitter ⚠
- p.Leu118Pro Single submitter ⚠
- p.Leu143Ser Single submitter ⚠
- p.Leu19Val Single submitter ⚠
- p.Leu217Phe Single submitter ⚠
- p.Lys165Glu Single submitter ⚠
- p.Lys176Ile Single submitter ⚠
- p.Lys39Thr Single submitter ⚠
- p.Met237Thr Single submitter ⚠
- p.Met62Val Single submitter ⚠
- p.Met97Ile Single submitter ⚠
- p.Phe119Ser Single submitter ⚠
- p.Phe186Leu Single submitter ⚠
- p.Pro178Ser Single submitter ⚠
- p.Ser200Pro Single submitter ⚠
- p.Thr101Ser Single submitter ⚠
- p.Thr184Ile Single submitter ⚠
- p.Thr227Lys Single submitter ⚠
- p.Thr77Ile Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val64Ile Single submitter ⚠