TAS2R9 — 49 ClinVar variants
All ClinVar germline TAS2R9 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
3 Benign · 5 Likely benign · 41 Uncertain significance
Full TAS2R9 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TAS2R9 p.Ala112Ser Uncertain significance Single submitter
- TAS2R9 p.Ala132Val Uncertain significance Single submitter
- TAS2R9 p.Ala216Val Uncertain significance Single submitter
- TAS2R9 p.Asn127His Uncertain significance Single submitter
- TAS2R9 p.Asp40Gly Uncertain significance Single submitter
- TAS2R9 p.Cys60Tyr Uncertain significance Single submitter
- TAS2R9 p.Gln259Glu Uncertain significance Single submitter
- TAS2R9 p.Gly15Ser Uncertain significance Single submitter
- TAS2R9 p.Gly186Glu Uncertain significance Single submitter
- TAS2R9 p.Ile11Val Uncertain significance Single submitter
- TAS2R9 p.Ile140Thr Uncertain significance Single submitter
- TAS2R9 p.Ile242Val Uncertain significance Single submitter
- TAS2R9 p.Ile44Phe Uncertain significance Single submitter
- TAS2R9 p.Leu142Val Uncertain significance Single submitter
- TAS2R9 p.Leu17Met Uncertain significance Single submitter
- TAS2R9 p.Leu282Gln Uncertain significance Single submitter
- TAS2R9 p.Leu294Met Uncertain significance Single submitter
- TAS2R9 p.Lys125Asn Uncertain significance Single submitter
- TAS2R9 p.Lys148Glu Uncertain significance Single submitter
- TAS2R9 p.Met265Thr Uncertain significance Single submitter
- TAS2R9 p.Pro117Thr Uncertain significance Single submitter
- TAS2R9 p.Pro312Ser Uncertain significance Single submitter
- TAS2R9 p.Ser223Ile Uncertain significance Single submitter
- TAS2R9 p.Ser54Thr Uncertain significance Single submitter
- TAS2R9 p.Thr166Ile Uncertain significance Single submitter
- TAS2R9 p.Thr182Ser Uncertain significance Single submitter
- TAS2R9 p.Thr75Ile Uncertain significance Single submitter
- TAS2R9 p.Trp153Arg Uncertain significance Single submitter
- TAS2R9 p.Val171Met Uncertain significance Single submitter
- TAS2R9 p.Val189Phe Uncertain significance Single submitter
- TAS2R9 p.Val82Leu Uncertain significance Single submitter
- TAS2R9 p.Val85Glu Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TAS2R9 p.Asn31Asp Uncertain significance Single submitter
- TAS2R9 p.Cys102Arg Uncertain significance Single submitter
- TAS2R9 p.Glu16Lys Uncertain significance Single submitter
- TAS2R9 p.Leu71Pro Uncertain significance Single submitter
- TAS2R9 p.Lys288Asn Uncertain significance Single submitter
- TAS2R9 p.Ser197Pro Uncertain significance Single submitter
- TAS2R9 p.Trp35Gly Uncertain significance Single submitter
All TAS2R9 variants
Benign 3
- p.Asp150Glu Multiple submitters
- p.Gly218Glu Multiple submitters
- p.Phe67Leu Single submitter
Likely benign 5
- p.Ala255Thr Single submitter
- p.Asp150Asn Single submitter
- p.Cys194Ser Single submitter
- p.Gly74Asp Single submitter
- p.Ser160Asn Single submitter
Uncertain significance 41
- p.Ala112Ser Single submitter ⚠
- p.Ala132Val Single submitter ⚠
- p.Ala216Val Single submitter ⚠
- p.Asn127His Single submitter ⚠
- p.Asn31Asp Single submitter ⚠
- p.Asp40Gly Single submitter ⚠
- p.Cys102Arg Single submitter ⚠
- p.Cys60Tyr Single submitter ⚠
- p.Gln259Glu Single submitter ⚠
- p.Glu16Lys Single submitter ⚠
- p.Gly15Ser Single submitter ⚠
- p.Gly186Glu Single submitter ⚠
- p.Ile111Arg Single submitter
- p.Ile11Val Single submitter ⚠
- p.Ile140Thr Single submitter ⚠
- p.Ile242Val Single submitter ⚠
- p.Ile44Phe Single submitter ⚠
- p.Leu142Val Single submitter ⚠
- p.Leu17Met Single submitter ⚠
- p.Leu282Gln Single submitter ⚠
- p.Leu294Met Single submitter ⚠
- p.Leu71Pro Single submitter ⚠
- p.Lys125Asn Single submitter ⚠
- p.Lys148Glu Single submitter ⚠
- p.Lys288Asn Single submitter ⚠
- p.Met265Thr Single submitter ⚠
- p.Pro117Thr Single submitter ⚠
- p.Pro190Ser Single submitter
- p.Pro312Ser Single submitter ⚠
- p.Ser197Pro Single submitter ⚠
- p.Ser223Ile Single submitter ⚠
- p.Ser54Thr Single submitter ⚠
- p.Thr166Ile Single submitter ⚠
- p.Thr182Ser Single submitter ⚠
- p.Thr75Ile Single submitter ⚠
- p.Trp153Arg Single submitter ⚠
- p.Trp35Gly Single submitter ⚠
- p.Val171Met Single submitter ⚠
- p.Val189Phe Single submitter ⚠
- p.Val82Leu Single submitter ⚠
- p.Val85Glu Single submitter ⚠