TBC1D15 — 74 ClinVar variants
All ClinVar germline TBC1D15 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
3 Likely benign · 71 Uncertain significance
Full TBC1D15 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 56
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TBC1D15 c.658-312A>C Uncertain significance Single submitter
- TBC1D15 p.Ala260Val Uncertain significance Single submitter
- TBC1D15 p.Ala2Ser Uncertain significance Single submitter
- TBC1D15 p.Ala456Ser Uncertain significance Single submitter
- TBC1D15 p.Ala654Pro Uncertain significance Single submitter
- TBC1D15 p.Arg670Thr Uncertain significance Single submitter
- TBC1D15 p.Asn113Ser Uncertain significance Single submitter
- TBC1D15 p.Asn199Asp Uncertain significance Single submitter
- TBC1D15 p.Asn320Asp Uncertain significance Single submitter
- TBC1D15 p.Asn320Ile Uncertain significance Single submitter
- TBC1D15 p.Asp115Glu Uncertain significance Single submitter
- TBC1D15 p.Asp402Val Uncertain significance Single submitter
- TBC1D15 p.Asp412Asn Uncertain significance Single submitter
- TBC1D15 p.Asp585Asn Uncertain significance Single submitter
- TBC1D15 p.Asp624Glu Uncertain significance Single submitter
- TBC1D15 p.Cys24Ser Uncertain significance Single submitter
- TBC1D15 p.Cys459Arg Uncertain significance Single submitter
- TBC1D15 p.Glu298Lys Uncertain significance Single submitter
- TBC1D15 p.Glu538Lys Uncertain significance Single submitter
- TBC1D15 p.Gly144Asp Uncertain significance Single submitter
- TBC1D15 p.Gly289Val Uncertain significance Single submitter
- TBC1D15 p.Ile12Thr Uncertain significance Single submitter
- TBC1D15 p.Ile315Phe Uncertain significance Single submitter
- TBC1D15 p.Ile37Val Uncertain significance Single submitter
- TBC1D15 p.Ile560Val Uncertain significance Single submitter
- TBC1D15 p.Ile586Thr Uncertain significance Single submitter
- TBC1D15 p.Leu302Val Uncertain significance Single submitter
- TBC1D15 p.Leu419Val Uncertain significance Single submitter
- TBC1D15 p.Leu488Val Uncertain significance Single submitter
- TBC1D15 p.Leu546His Uncertain significance Single submitter
- TBC1D15 p.Lys81Glu Uncertain significance Single submitter
- TBC1D15 p.Met100Val Uncertain significance Single submitter
- TBC1D15 p.Met259Leu Uncertain significance Single submitter
- TBC1D15 p.Met369Val Uncertain significance Single submitter
- TBC1D15 p.Met535Leu Uncertain significance Single submitter
- TBC1D15 p.Met561Ile Uncertain significance Single submitter
- TBC1D15 p.Phe341Tyr Uncertain significance Single submitter
- TBC1D15 p.Phe519Leu Uncertain significance Single submitter
- TBC1D15 p.Pro256Arg Uncertain significance Single submitter
- TBC1D15 p.Pro256Ser Uncertain significance Single submitter
- TBC1D15 p.Ser23Cys Uncertain significance Single submitter
- TBC1D15 p.Ser247Asn Uncertain significance Single submitter
- TBC1D15 p.Ser350Thr Uncertain significance Single submitter
- TBC1D15 p.Ser385Leu Uncertain significance Single submitter
- TBC1D15 p.Ser494Asn Uncertain significance Single submitter
- TBC1D15 p.Ser665Thr Uncertain significance Single submitter
- TBC1D15 p.Ser93Asn Uncertain significance Single submitter
- TBC1D15 p.Thr227Met Uncertain significance Single submitter
- TBC1D15 p.Thr648Ile Uncertain significance Single submitter
- TBC1D15 p.Thr660Ala Uncertain significance Single submitter
- TBC1D15 p.Tyr19Cys Uncertain significance Single submitter
- TBC1D15 p.Val181Ala Uncertain significance Single submitter
- TBC1D15 p.Val625Ala Uncertain significance Single submitter
- TBC1D15 p.Val632Ile Uncertain significance Single submitter
- TBC1D15 p.Val664Leu Uncertain significance Single submitter
- TBC1D15 p.Val7Met Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TBC1D15 p.Arg386Ser Uncertain significance Single submitter
- TBC1D15 p.Asn575Ser Uncertain significance Single submitter
- TBC1D15 p.Asp582His Uncertain significance Single submitter
- TBC1D15 p.His166Arg Uncertain significance Single submitter
- TBC1D15 p.His21Pro Uncertain significance Single submitter
- TBC1D15 p.Ile517Met Uncertain significance Single submitter
- TBC1D15 p.Met145Ile Uncertain significance Single submitter
- TBC1D15 p.Met428Ile Uncertain significance Single submitter
- TBC1D15 p.Phe206Ser Uncertain significance Single submitter
- TBC1D15 p.Ser377Gly Uncertain significance Single submitter
- TBC1D15 p.Ser462Phe Uncertain significance Single submitter
- TBC1D15 p.Val534Ala Uncertain significance Single submitter
All TBC1D15 variants
Likely benign 3
- p.Arg108Lys Single submitter
- p.Gly32Ser Single submitter
- p.Ile586Val Single submitter
Uncertain significance 71
- c.1502-2A>G Single submitter
- c.658-312A>C Single submitter ⚠
- p.Ala260Val Single submitter ⚠
- p.Ala2Ser Single submitter ⚠
- p.Ala456Ser Single submitter ⚠
- p.Ala654Pro Single submitter ⚠
- p.Arg386Ser Single submitter ⚠
- p.Arg670Thr Single submitter ⚠
- p.Asn113Ser Single submitter ⚠
- p.Asn199Asp Single submitter ⚠
- p.Asn320Asp Single submitter ⚠
- p.Asn320Ile Single submitter ⚠
- p.Asn575Ser Single submitter ⚠
- p.Asp115Glu Single submitter ⚠
- p.Asp402Val Single submitter ⚠
- p.Asp412Asn Single submitter ⚠
- p.Asp582His Single submitter ⚠
- p.Asp585Asn Single submitter ⚠
- p.Asp624Glu Single submitter ⚠
- p.Cys24Ser Single submitter ⚠
- p.Cys459Arg Single submitter ⚠
- p.Gln275Ter Single submitter
- p.Glu298Lys Single submitter ⚠
- p.Glu538Lys Single submitter ⚠
- p.Gly144Asp Single submitter ⚠
- p.Gly289Val Single submitter ⚠
- p.His166Arg Single submitter ⚠
- p.His21Pro Single submitter ⚠
- p.His420Arg Single submitter
- p.Ile12Thr Single submitter ⚠
- p.Ile315Phe Single submitter ⚠
- p.Ile37Val Single submitter ⚠
- p.Ile517Met Single submitter ⚠
- p.Ile560Val Single submitter ⚠
- p.Ile586Thr Single submitter ⚠
- p.Leu302Val Single submitter ⚠
- p.Leu419Val Single submitter ⚠
- p.Leu488Val Single submitter ⚠
- p.Leu546His Single submitter ⚠
- p.Lys81Glu Single submitter ⚠
- p.Met100Val Single submitter ⚠
- p.Met145Ile Single submitter ⚠
- p.Met259Leu Single submitter ⚠
- p.Met369Val Single submitter ⚠
- p.Met428Ile Single submitter ⚠
- p.Met535Leu Single submitter ⚠
- p.Met561Ile Single submitter ⚠
- p.Phe206Ser Single submitter ⚠
- p.Phe341Tyr Single submitter ⚠
- p.Phe519Leu Single submitter ⚠
- p.Pro256Arg Single submitter ⚠
- p.Pro256Ser Single submitter ⚠
- p.Ser23Cys Single submitter ⚠
- p.Ser247Asn Single submitter ⚠
- p.Ser350Thr Single submitter ⚠
- p.Ser377Gly Single submitter ⚠
- p.Ser385Leu Single submitter ⚠
- p.Ser462Phe Single submitter ⚠
- p.Ser494Asn Single submitter ⚠
- p.Ser665Thr Single submitter ⚠
- p.Ser93Asn Single submitter ⚠
- p.Thr227Met Single submitter ⚠
- p.Thr648Ile Single submitter ⚠
- p.Thr660Ala Single submitter ⚠
- p.Tyr19Cys Single submitter ⚠
- p.Val181Ala Single submitter ⚠
- p.Val534Ala Single submitter ⚠
- p.Val625Ala Single submitter ⚠
- p.Val632Ile Single submitter ⚠
- p.Val664Leu Single submitter ⚠
- p.Val7Met Single submitter ⚠