TCERG1 — 112 ClinVar variants
All ClinVar germline TCERG1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 97 flagged for review →
1 Pathogenic · 1 Benign · 11 Likely benign · 99 Uncertain significance
Full TCERG1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 97
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 61
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TCERG1 p.Ala189Val Uncertain significance Single submitter
- TCERG1 p.Ala195Val Uncertain significance Single submitter
- TCERG1 p.Ala205Val Uncertain significance Single submitter
- TCERG1 p.Ala253Val Uncertain significance Single submitter
- TCERG1 p.Ala424Ser Uncertain significance Single submitter
- TCERG1 p.Ala429Val Uncertain significance Single submitter
- TCERG1 p.Ala745Thr Uncertain significance Single submitter
- TCERG1 p.Ala795Val Uncertain significance Single submitter
- TCERG1 p.Ala796Thr Uncertain significance Single submitter
- TCERG1 p.Arg1019Lys Uncertain significance Single submitter
- TCERG1 p.Arg153Trp Uncertain significance Single submitter
- TCERG1 p.Arg4Gly Uncertain significance Single submitter
- TCERG1 p.Arg4Leu Uncertain significance Single submitter
- TCERG1 p.Arg710Gln Uncertain significance Single submitter
- TCERG1 p.Arg736Lys Uncertain significance Single submitter
- TCERG1 p.Arg798Lys Uncertain significance Single submitter
- TCERG1 p.Asp493Gly Uncertain significance Single submitter
- TCERG1 p.Asp541Val Uncertain significance Single submitter
- TCERG1 p.Asp649Gly Uncertain significance Single submitter
- TCERG1 p.Gln304Arg Uncertain significance Single submitter
- TCERG1 p.Gln330His Uncertain significance Single submitter
- TCERG1 p.Gln330Pro Uncertain significance Single submitter
- TCERG1 p.Gln601Leu Uncertain significance Single submitter
- TCERG1 p.Glu574Asp Uncertain significance Single submitter
- TCERG1 p.Glu801Asp Uncertain significance Single submitter
- TCERG1 p.Gly83Val Uncertain significance Single submitter
- TCERG1 p.Gly8Ala Uncertain significance Single submitter
- TCERG1 p.Gly8Trp Uncertain significance Single submitter
- TCERG1 p.Ile419Val Uncertain significance Single submitter
- TCERG1 p.Ile499Val Uncertain significance Single submitter
- TCERG1 p.Ile780Thr Uncertain significance Single submitter
- TCERG1 p.Lys500Arg Uncertain significance Single submitter
- TCERG1 p.Lys570Arg Uncertain significance Single submitter
- TCERG1 p.Lys799Arg Uncertain significance Single submitter
- TCERG1 p.Lys921Arg Uncertain significance Single submitter
- TCERG1 p.Met412Val Uncertain significance Single submitter
- TCERG1 p.Met614Ile Uncertain significance Single submitter
- TCERG1 p.Met79Ile Uncertain significance Single submitter
- TCERG1 p.Met89Leu Uncertain significance Single submitter
- TCERG1 p.Pro16Arg Uncertain significance Single submitter
- TCERG1 p.Pro328Ser Uncertain significance Single submitter
- TCERG1 p.Pro32Leu Uncertain significance Single submitter
- TCERG1 p.Pro335Leu Uncertain significance Single submitter
- TCERG1 p.Pro65Leu Uncertain significance Single submitter
- TCERG1 p.Ser1011Phe Uncertain significance Single submitter
- TCERG1 p.Ser11Asn Uncertain significance Single submitter
- TCERG1 p.Ser347Pro Uncertain significance Single submitter
- TCERG1 p.Ser605Asn Uncertain significance Single submitter
- TCERG1 p.Ser805Leu Uncertain significance Single submitter
- TCERG1 p.Ser840Gly Uncertain significance Single submitter
- TCERG1 p.Thr300Ala Uncertain significance Single submitter
- TCERG1 p.Thr325Lys Uncertain significance Single submitter
- TCERG1 p.Thr397Asn Uncertain significance Single submitter
- TCERG1 p.Thr425Ala Uncertain significance Single submitter
- TCERG1 p.Tyr148Cys Uncertain significance Single submitter
- TCERG1 p.Val183Ala Uncertain significance Single submitter
- TCERG1 p.Val329Ala Uncertain significance Single submitter
- TCERG1 p.Val332Ile Uncertain significance Single submitter
- TCERG1 p.Val348Ala Uncertain significance Single submitter
- TCERG1 p.Val410Ile Uncertain significance Single submitter
- TCERG1 p.Val722Met Uncertain significance Single submitter
Predictors split 36
The independent predictors disagree with each other — read with care.
- TCERG1 p.Ala191Ser Uncertain significance Single submitter
- TCERG1 p.Ala245Val Uncertain significance Single submitter
- TCERG1 p.Ala663Thr Uncertain significance Single submitter
- TCERG1 p.Ala896Thr Uncertain significance Single submitter
- TCERG1 p.Arg1085Cys Uncertain significance Single submitter
- TCERG1 p.Arg41Gln Uncertain significance Single submitter
- TCERG1 p.Arg48Leu Uncertain significance Single submitter
- TCERG1 p.Arg628Trp Uncertain significance Single submitter
- TCERG1 p.Arg669Gln Uncertain significance Single submitter
- TCERG1 p.Arg878Lys Uncertain significance Single submitter
- TCERG1 p.Asn450Asp Uncertain significance Single submitter
- TCERG1 p.Asp848Gly Uncertain significance Single submitter
- TCERG1 p.Asp983Gly Uncertain significance Single submitter
- TCERG1 p.Gln198Glu Uncertain significance Single submitter
- TCERG1 p.Gln212Arg Uncertain significance Single submitter
- TCERG1 p.Gln224Arg Uncertain significance Single submitter
- TCERG1 p.Gln234Glu Uncertain significance Single submitter
- TCERG1 p.Gln252Lys Uncertain significance Single submitter
- TCERG1 p.Glu574Lys Uncertain significance Single submitter
- TCERG1 p.Glu907Asp Uncertain significance Single submitter
- TCERG1 p.Gly112Arg Uncertain significance Single submitter
- TCERG1 p.Gly428Glu Uncertain significance Single submitter
- TCERG1 p.Gly580Arg Uncertain significance Single submitter
- TCERG1 p.His824Arg Uncertain significance Single submitter
- TCERG1 p.Leu1087Val Uncertain significance Single submitter
- TCERG1 p.Lys466Glu Uncertain significance Single submitter
- TCERG1 p.Lys782Asn Uncertain significance Single submitter
- TCERG1 p.Met743Ile Uncertain significance Single submitter
- TCERG1 p.Pro1081Arg Uncertain significance Single submitter
- TCERG1 p.Pro109Arg Uncertain significance Single submitter
- TCERG1 p.Pro364Thr Uncertain significance Single submitter
- TCERG1 p.Pro407Ser Uncertain significance Single submitter
- TCERG1 p.Pro92Leu Uncertain significance Single submitter
- TCERG1 p.Ser986Cys Uncertain significance Single submitter
- TCERG1 p.Thr160Ile Uncertain significance Single submitter
- TCERG1 p.Thr274Lys Uncertain significance Single submitter
All TCERG1 variants
Pathogenic 1
- p.Pro65fs No assertion criteria colorectal cancer
Benign 1
- p.Pro279Leu Single submitter
Likely benign 11
Uncertain significance 99
- p.Ala189Val Single submitter ⚠
- p.Ala191Ser Single submitter ⚠
- p.Ala195Val Single submitter ⚠
- p.Ala205Val Single submitter ⚠
- p.Ala245Val Single submitter ⚠
- p.Ala253Val Single submitter ⚠
- p.Ala424Ser Single submitter ⚠
- p.Ala429Val Single submitter ⚠
- p.Ala663Thr Single submitter ⚠
- p.Ala745Thr Single submitter ⚠
- p.Ala795Val Single submitter ⚠
- p.Ala796Thr Single submitter ⚠
- p.Ala896Thr Single submitter ⚠
- p.Arg1019Lys Single submitter ⚠
- p.Arg1085Cys Single submitter ⚠
- p.Arg153Trp Single submitter ⚠
- p.Arg41Gln Single submitter ⚠
- p.Arg48Leu Single submitter ⚠
- p.Arg4Gly Single submitter ⚠
- p.Arg4Leu Single submitter ⚠
- p.Arg628Trp Single submitter ⚠
- p.Arg669Gln Single submitter ⚠
- p.Arg710Gln Single submitter ⚠
- p.Arg736Lys Single submitter ⚠
- p.Arg798Lys Single submitter ⚠
- p.Arg878Lys Single submitter ⚠
- p.Asn450Asp Single submitter ⚠
- p.Asp493Gly Single submitter ⚠
- p.Asp541Val Single submitter ⚠
- p.Asp649Gly Single submitter ⚠
- p.Asp848Gly Single submitter ⚠
- p.Asp983Gly Single submitter ⚠
- p.Gln198Glu Single submitter ⚠
- p.Gln212Arg Single submitter ⚠
- p.Gln224Arg Single submitter ⚠
- p.Gln234Glu Single submitter ⚠
- p.Gln252Lys Single submitter ⚠
- p.Gln304Arg Single submitter ⚠
- p.Gln330His Single submitter ⚠
- p.Gln330Pro Single submitter ⚠
- p.Gln601Leu Single submitter ⚠
- p.Glu10fs Single submitter
- p.Glu574Asp Single submitter ⚠
- p.Glu574Lys Single submitter ⚠
- p.Glu801Asp Single submitter ⚠
- p.Glu907Asp Single submitter ⚠
- p.Gly112Arg Single submitter ⚠
- p.Gly428Glu Single submitter ⚠
- p.Gly580Arg Single submitter ⚠
- p.Gly83Val Single submitter ⚠
- p.Gly8Ala Single submitter ⚠
- p.Gly8Trp Single submitter ⚠
- p.His577fs Single submitter
- p.His824Arg Single submitter ⚠
- p.Ile419Val Single submitter ⚠
- p.Ile499Val Single submitter ⚠
- p.Ile780Thr Single submitter ⚠
- p.Leu1087Val Single submitter ⚠
- p.Lys466Glu Single submitter ⚠
- p.Lys500Arg Single submitter ⚠
- p.Lys570Arg Single submitter ⚠
- p.Lys782Asn Single submitter ⚠
- p.Lys799Arg Single submitter ⚠
- p.Lys921Arg Single submitter ⚠
- p.Met412Val Single submitter ⚠
- p.Met614Ile Single submitter ⚠
- p.Met743Ile Single submitter ⚠
- p.Met79Ile Single submitter ⚠
- p.Met89Leu Single submitter ⚠
- p.Pro1081Arg Single submitter ⚠
- p.Pro109Arg Single submitter ⚠
- p.Pro16Arg Single submitter ⚠
- p.Pro328Ser Single submitter ⚠
- p.Pro32Leu Single submitter ⚠
- p.Pro335Leu Single submitter ⚠
- p.Pro364Thr Single submitter ⚠
- p.Pro407Ser Single submitter ⚠
- p.Pro65Leu Single submitter ⚠
- p.Pro92Leu Single submitter ⚠
- p.Ser1011Phe Single submitter ⚠
- p.Ser11Asn Single submitter ⚠
- p.Ser347Pro Single submitter ⚠
- p.Ser605Asn Single submitter ⚠
- p.Ser805Leu Single submitter ⚠
- p.Ser840Gly Single submitter ⚠
- p.Ser986Cys Single submitter ⚠
- p.Thr160Ile Single submitter ⚠
- p.Thr274Lys Single submitter ⚠
- p.Thr300Ala Single submitter ⚠
- p.Thr325Lys Single submitter ⚠
- p.Thr397Asn Single submitter ⚠
- p.Thr425Ala Single submitter ⚠
- p.Tyr148Cys Single submitter ⚠
- p.Val183Ala Single submitter ⚠
- p.Val329Ala Single submitter ⚠
- p.Val332Ile Single submitter ⚠
- p.Val348Ala Single submitter ⚠
- p.Val410Ile Single submitter ⚠
- p.Val722Met Single submitter ⚠