Sugi Variant

Sugi Variant/TCF3

TCF3 — 1195 ClinVar variants

All ClinVar germline TCF3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 489 flagged for review →

20 Pathogenic · 14 Likely pathogenic · 45 Conflicting · 25 Benign · 35 Benign/Likely benign · 506 Likely benign · 550 Uncertain significance

Full TCF3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 489

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 31

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 406

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 406

Predictors split 52

The independent predictors disagree with each other — read with care.

All TCF3 variants

Pathogenic 20

Likely pathogenic 14

Conflicting classifications of pathogenicity 45

Benign 25

Benign/Likely benign 35

Likely benign 506

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 550

Showing the top 300 by review status; the full set is in the sitemap.