TDO2 — 58 ClinVar variants
All ClinVar germline TDO2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 44 flagged for review →
2 Benign · 1 Benign/Likely benign · 6 Likely benign · 49 Uncertain significance
Full TDO2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 44
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 35
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TDO2 p.Arg159Gln Uncertain significance Single submitter
- TDO2 p.Arg181His Uncertain significance Single submitter
- TDO2 p.Arg181Leu Uncertain significance Single submitter
- TDO2 p.Arg272His Uncertain significance Single submitter
- TDO2 p.Arg94Gln Uncertain significance Single submitter
- TDO2 p.Arg94Pro Uncertain significance Single submitter
- TDO2 p.Asp316Ala Uncertain significance Single submitter
- TDO2 p.Asp364His Uncertain significance Single submitter
- TDO2 p.Gln258Glu Uncertain significance Single submitter
- TDO2 p.Gln55Lys Uncertain significance Single submitter
- TDO2 p.Gln58Arg Uncertain significance Single submitter
- TDO2 p.Gln58Lys Uncertain significance Single submitter
- TDO2 p.Glu56Gly Uncertain significance Single submitter
- TDO2 p.Glu60Lys Uncertain significance Single submitter
- TDO2 p.Glu95Gln Uncertain significance Single submitter
- TDO2 p.Gly152Ser Uncertain significance Single submitter
- TDO2 p.Gly186Glu Uncertain significance Single submitter
- TDO2 p.Gly224Arg Uncertain significance Single submitter
- TDO2 p.Gly280Asp Uncertain significance Single submitter
- TDO2 p.Gly341Asp Uncertain significance Single submitter
- TDO2 p.His101Arg Uncertain significance Single submitter
- TDO2 p.Ile74Val Uncertain significance Single submitter
- TDO2 p.Leu168Pro Uncertain significance Single submitter
- TDO2 p.Leu365Ser Uncertain significance Single submitter
- TDO2 p.Met381Leu Uncertain significance Single submitter
- TDO2 p.Pro213Leu Uncertain significance Single submitter
- TDO2 p.Ser130Phe Uncertain significance Single submitter
- TDO2 p.Ser23Arg Uncertain significance Single submitter
- TDO2 p.Ser28Pro Uncertain significance Single submitter
- TDO2 p.Ser2Thr Uncertain significance Single submitter
- TDO2 p.Thr212Ile Uncertain significance Single submitter
- TDO2 p.Thr370Ile Uncertain significance Single submitter
- TDO2 p.Thr391Ile Uncertain significance Single submitter
- TDO2 p.Val126Leu Uncertain significance Single submitter
- TDO2 p.Val332Met Uncertain significance Single submitter
Predictors split 9
The independent predictors disagree with each other — read with care.
- TDO2 p.Gln242Pro Uncertain significance Single submitter
- TDO2 p.Gly337Ser Uncertain significance Single submitter
- TDO2 p.His349Tyr Uncertain significance Single submitter
- TDO2 p.Met294Ile Uncertain significance Single submitter
- TDO2 p.Pro307Ser Uncertain significance Single submitter
- TDO2 p.Ser119Pro Benign Single submitter
- TDO2 p.Ser266Phe Uncertain significance Single submitter
- TDO2 p.Val167Ala Uncertain significance Single submitter
- TDO2 p.Val329Ala Uncertain significance Single submitter
All TDO2 variants
Benign 2
- p.Ser119Pro Single submitter ⚠
- p.Asn229His No assertion criteria TDO2-related disorder
Benign/Likely benign 1
- p.Val306= Multiple submitters
Likely benign 6
- c.432-7C>T Single submitter
- c.618+15A>G Single submitter
- c.838+16T>C Single submitter
- p.Leu226= No assertion criteria TDO2-related disorder
- p.Phe268Tyr No assertion criteria TDO2-related disorder
- p.Ser402= No assertion criteria TDO2-related disorder
Uncertain significance 49
- p.Ala137Val Single submitter
- p.Ala35Asp Single submitter
- p.Arg114Gln Single submitter
- p.Arg159Gln Single submitter ⚠
- p.Arg181His Single submitter ⚠
- p.Arg181Leu Single submitter ⚠
- p.Arg272His Single submitter ⚠
- p.Arg94Gln Single submitter ⚠
- p.Arg94Pro Single submitter ⚠
- p.Asp316Ala Single submitter ⚠
- p.Asp364His Single submitter ⚠
- p.Gln242Pro Single submitter ⚠
- p.Gln258Glu Single submitter ⚠
- p.Gln55Lys Single submitter ⚠
- p.Gln58Arg Single submitter ⚠
- p.Gln58Lys Single submitter ⚠
- p.Glu56Gly Single submitter ⚠
- p.Glu60Lys Single submitter ⚠
- p.Glu95Gln Single submitter ⚠
- p.Gly152Ser Single submitter ⚠
- p.Gly186Glu Single submitter ⚠
- p.Gly224Arg Single submitter ⚠
- p.Gly280Asp Single submitter ⚠
- p.Gly337Ser Single submitter ⚠
- p.Gly341Asp Single submitter ⚠
- p.Gly38Arg Single submitter
- p.His101Arg Single submitter ⚠
- p.His349Tyr Single submitter ⚠
- p.Ile74Val Single submitter ⚠
- p.Ile96Asn Single submitter
- p.Leu168Pro Single submitter ⚠
- p.Leu320Arg Single submitter
- p.Leu365Ser Single submitter ⚠
- p.Met294Ile Single submitter ⚠
- p.Met381Leu Single submitter ⚠
- p.Pro213Leu Single submitter ⚠
- p.Pro307Ser Single submitter ⚠
- p.Ser130Phe Single submitter ⚠
- p.Ser23Arg Single submitter ⚠
- p.Ser266Phe Single submitter ⚠
- p.Ser28Pro Single submitter ⚠
- p.Ser2Thr Single submitter ⚠
- p.Thr212Ile Single submitter ⚠
- p.Thr370Ile Single submitter ⚠
- p.Thr391Ile Single submitter ⚠
- p.Val126Leu Single submitter ⚠
- p.Val167Ala Single submitter ⚠
- p.Val329Ala Single submitter ⚠
- p.Val332Met Single submitter ⚠