Sugi Variant

Sugi Variant/TDRD7

TDRD7 — 272 ClinVar variants

All ClinVar germline TDRD7 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 167 flagged for review →

7 Pathogenic · 3 Likely pathogenic · 13 Conflicting · 26 Benign · 5 Benign/Likely benign · 39 Likely benign · 179 Uncertain significance

Full TDRD7 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 167

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 5

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 143

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 18

The independent predictors disagree with each other — read with care.

All TDRD7 variants

Pathogenic 7

Likely pathogenic 3

Conflicting classifications of pathogenicity 13

Benign 26

Benign/Likely benign 5

Likely benign 39

Uncertain significance 179