TEAD3 — 43 ClinVar variants
All ClinVar germline TEAD3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 40 flagged for review →
43 Uncertain significance
Full TEAD3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 40
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEAD3 p.Ala127Thr Uncertain significance Single submitter
- TEAD3 p.Ala257Thr Uncertain significance Single submitter
- TEAD3 p.Ala8Pro Uncertain significance Single submitter
- TEAD3 p.Arg218Cys Uncertain significance Single submitter
- TEAD3 p.Arg224Gln Uncertain significance Single submitter
- TEAD3 p.Arg226Gln Uncertain significance Single submitter
- TEAD3 p.Arg238Gln Uncertain significance Single submitter
- TEAD3 p.Arg357His Uncertain significance Single submitter
- TEAD3 p.Arg361His Uncertain significance Single submitter
- TEAD3 p.Arg403Trp Uncertain significance Single submitter
- TEAD3 p.Arg55Trp Uncertain significance Single submitter
- TEAD3 p.Asp302Asn Uncertain significance Single submitter
- TEAD3 p.Gln141Lys Uncertain significance Single submitter
- TEAD3 p.Glu17Gly Uncertain significance Single submitter
- TEAD3 p.Glu277Ala Uncertain significance Single submitter
- TEAD3 p.Gly13Arg Uncertain significance Single submitter
- TEAD3 p.Gly252Ser Uncertain significance Single submitter
- TEAD3 p.Gly33Ser Uncertain significance Single submitter
- TEAD3 p.Met371Ile Uncertain significance Single submitter
- TEAD3 p.Phe314Leu Uncertain significance Single submitter
- TEAD3 p.Pro146Ser Uncertain significance Single submitter
- TEAD3 p.Pro174Thr Uncertain significance Single submitter
- TEAD3 p.Pro190Ser Uncertain significance Single submitter
- TEAD3 p.Pro191Thr Uncertain significance Single submitter
- TEAD3 p.Pro194Ser Uncertain significance Single submitter
- TEAD3 p.Ser36Cys Uncertain significance Single submitter
- TEAD3 p.Thr195Met Uncertain significance Single submitter
- TEAD3 p.Trp215Cys Uncertain significance Single submitter
- TEAD3 p.Val331Ile Uncertain significance Single submitter
- TEAD3 p.Val342Met Uncertain significance Single submitter
- TEAD3 p.Val346Leu Uncertain significance Single submitter
- TEAD3 p.Val359Met Uncertain significance Single submitter
- TEAD3 p.Val433Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TEAD3 p.Ala265Thr Uncertain significance Single submitter
- TEAD3 p.His380Gln Uncertain significance Single submitter
- TEAD3 p.Ile396Val Uncertain significance Single submitter
- TEAD3 p.Ser175Phe Uncertain significance Single submitter
- TEAD3 p.Thr219Ile Uncertain significance Single submitter
- TEAD3 p.Thr401Met Uncertain significance Single submitter
- TEAD3 p.Tyr272Cys Uncertain significance Single submitter
All TEAD3 variants
Uncertain significance 43
- p.Ala127Thr Single submitter ⚠
- p.Ala257Thr Single submitter ⚠
- p.Ala265Thr Single submitter ⚠
- p.Ala8Pro Single submitter ⚠
- p.Arg218Cys Single submitter ⚠
- p.Arg224Gln Single submitter ⚠
- p.Arg226Gln Single submitter ⚠
- p.Arg226Trp Single submitter
- p.Arg238Gln Single submitter ⚠
- p.Arg357His Single submitter ⚠
- p.Arg361Cys Single submitter
- p.Arg361His Single submitter ⚠
- p.Arg403Trp Single submitter ⚠
- p.Arg55Trp Single submitter ⚠
- p.Asp302Asn Single submitter ⚠
- p.Gln141Lys Single submitter ⚠
- p.Glu17Gly Single submitter ⚠
- p.Glu277Ala Single submitter ⚠
- p.Gly13Arg Single submitter ⚠
- p.Gly252Ser Single submitter ⚠
- p.Gly33Ser Single submitter ⚠
- p.His380Gln Single submitter ⚠
- p.His423Tyr Single submitter
- p.Ile396Val Single submitter ⚠
- p.Met371Ile Single submitter ⚠
- p.Phe314Leu Single submitter ⚠
- p.Pro146Ser Single submitter ⚠
- p.Pro174Thr Single submitter ⚠
- p.Pro190Ser Single submitter ⚠
- p.Pro191Thr Single submitter ⚠
- p.Pro194Ser Single submitter ⚠
- p.Ser175Phe Single submitter ⚠
- p.Ser36Cys Single submitter ⚠
- p.Thr195Met Single submitter ⚠
- p.Thr219Ile Single submitter ⚠
- p.Thr401Met Single submitter ⚠
- p.Trp215Cys Single submitter ⚠
- p.Tyr272Cys Single submitter ⚠
- p.Val331Ile Single submitter ⚠
- p.Val342Met Single submitter ⚠
- p.Val346Leu Single submitter ⚠
- p.Val359Met Single submitter ⚠
- p.Val433Ile Single submitter ⚠