TEAD4 — 67 ClinVar variants
All ClinVar germline TEAD4 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 61 flagged for review →
4 Likely benign · 63 Uncertain significance
Full TEAD4 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 61
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 51
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEAD4 p.Ala115Thr Uncertain significance Single submitter
- TEAD4 p.Ala166Val Uncertain significance Single submitter
- TEAD4 p.Ala211Val Uncertain significance Single submitter
- TEAD4 p.Ala264Ser Uncertain significance Single submitter
- TEAD4 p.Ala30Ser Uncertain significance Single submitter
- TEAD4 p.Ala424Pro Uncertain significance Single submitter
- TEAD4 p.Ala56Thr Uncertain significance Single submitter
- TEAD4 p.Arg108Cys Uncertain significance Single submitter
- TEAD4 p.Arg111Pro Uncertain significance Single submitter
- TEAD4 p.Arg156His Uncertain significance Single submitter
- TEAD4 p.Arg287Gln Uncertain significance Single submitter
- TEAD4 p.Arg77Trp Uncertain significance Single submitter
- TEAD4 p.Arg83Cys Uncertain significance Single submitter
- TEAD4 p.Arg88Gln Uncertain significance Single submitter
- TEAD4 p.Asn37Ser Uncertain significance Single submitter
- TEAD4 p.Asp119His Uncertain significance Single submitter
- TEAD4 p.Cys410Tyr Uncertain significance Single submitter
- TEAD4 p.Gln120His Uncertain significance Single submitter
- TEAD4 p.Gln215Glu Uncertain significance Single submitter
- TEAD4 p.Glu263Lys Uncertain significance Single submitter
- TEAD4 p.Gly155Ser Uncertain significance Single submitter
- TEAD4 p.Gly161Arg Uncertain significance Single submitter
- TEAD4 p.Gly201Val Uncertain significance Single submitter
- TEAD4 p.His175Leu Uncertain significance Single submitter
- TEAD4 p.His375Gln Uncertain significance Single submitter
- TEAD4 p.His427Tyr Uncertain significance Single submitter
- TEAD4 p.Ile113Val Uncertain significance Single submitter
- TEAD4 p.Ile306Met Uncertain significance Single submitter
- TEAD4 p.Ile85Val Uncertain significance Single submitter
- TEAD4 p.Pro192Ser Uncertain significance Single submitter
- TEAD4 p.Pro199Ser Uncertain significance Single submitter
- TEAD4 p.Pro209Ser Uncertain significance Single submitter
- TEAD4 p.Ser100Arg Uncertain significance Single submitter
- TEAD4 p.Ser147Arg Uncertain significance Single submitter
- TEAD4 p.Ser205Leu Uncertain significance Single submitter
- TEAD4 p.Ser222Pro Uncertain significance Single submitter
- TEAD4 p.Ser331Phe Uncertain significance Single submitter
- TEAD4 p.Ser44Asn Uncertain significance Single submitter
- TEAD4 p.Ser69Leu Uncertain significance Single submitter
- TEAD4 p.Thr173Met Uncertain significance Single submitter
- TEAD4 p.Thr184Ile Uncertain significance Single submitter
- TEAD4 p.Thr332Met Uncertain significance Single submitter
- TEAD4 p.Thr7Ile Uncertain significance Single submitter
- TEAD4 p.Thr94Ile Uncertain significance Single submitter
- TEAD4 p.Val104Glu Uncertain significance Single submitter
- TEAD4 p.Val159Asp Uncertain significance Single submitter
- TEAD4 p.Val187Ala Uncertain significance Single submitter
- TEAD4 p.Val248Met Uncertain significance Single submitter
- TEAD4 p.Val316Ala Uncertain significance Single submitter
- TEAD4 p.Val389Met Uncertain significance Single submitter
- TEAD4 p.Val42Met Uncertain significance Single submitter
Predictors split 10
The independent predictors disagree with each other — read with care.
- TEAD4 p.Arg152Trp Uncertain significance Single submitter
- TEAD4 p.Arg268Leu Uncertain significance Single submitter
- TEAD4 p.Asn291Ser Uncertain significance Single submitter
- TEAD4 p.Asp240Asn Uncertain significance Single submitter
- TEAD4 p.Glu276Gly Uncertain significance Single submitter
- TEAD4 p.Glu324Lys Uncertain significance Single submitter
- TEAD4 p.His426Tyr Uncertain significance Single submitter
- TEAD4 p.Lys378Arg Uncertain significance Single submitter
- TEAD4 p.Ser18Phe Uncertain significance Single submitter
- TEAD4 p.Val219Met Uncertain significance Single submitter
All TEAD4 variants
Likely benign 4
- c.584-4G>T Single submitter
- p.Ala203Thr Single submitter
- p.Asp176= Single submitter
- p.His422= Single submitter
Uncertain significance 63
- p.Ala115Thr Single submitter ⚠
- p.Ala136Val Single submitter
- p.Ala166Val Single submitter ⚠
- p.Ala211Val Single submitter ⚠
- p.Ala264Ser Single submitter ⚠
- p.Ala30Ser Single submitter ⚠
- p.Ala424Pro Single submitter ⚠
- p.Ala56Thr Single submitter ⚠
- p.Arg108Cys Single submitter ⚠
- p.Arg111Pro Single submitter ⚠
- p.Arg152Trp Single submitter ⚠
- p.Arg156His Single submitter ⚠
- p.Arg268Leu Single submitter ⚠
- p.Arg287Gln Single submitter ⚠
- p.Arg77Trp Single submitter ⚠
- p.Arg83Cys Single submitter ⚠
- p.Arg88Gln Single submitter ⚠
- p.Asn291Lys Single submitter
- p.Asn291Ser Single submitter ⚠
- p.Asn37Ser Single submitter ⚠
- p.Asp119His Single submitter ⚠
- p.Asp240Asn Single submitter ⚠
- p.Cys410Tyr Single submitter ⚠
- p.Gln120His Single submitter ⚠
- p.Gln215Glu Single submitter ⚠
- p.Glu263Lys Single submitter ⚠
- p.Glu276Gly Single submitter ⚠
- p.Glu324Lys Single submitter ⚠
- p.Gly155Ser Single submitter ⚠
- p.Gly161Arg Single submitter ⚠
- p.Gly201Val Single submitter ⚠
- p.His175Leu Single submitter ⚠
- p.His375Gln Single submitter ⚠
- p.His426Tyr Single submitter ⚠
- p.His427Tyr Single submitter ⚠
- p.Ile113Val Single submitter ⚠
- p.Ile306Met Single submitter ⚠
- p.Ile85Val Single submitter ⚠
- p.Lys378Arg Single submitter ⚠
- p.Pro192Ser Single submitter ⚠
- p.Pro199Ser Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Ser100Arg Single submitter ⚠
- p.Ser147Arg Single submitter ⚠
- p.Ser18Phe Single submitter ⚠
- p.Ser205Leu Single submitter ⚠
- p.Ser222Pro Single submitter ⚠
- p.Ser331Phe Single submitter ⚠
- p.Ser44Asn Single submitter ⚠
- p.Ser69Leu Single submitter ⚠
- p.Thr173Met Single submitter ⚠
- p.Thr184Ile Single submitter ⚠
- p.Thr332Met Single submitter ⚠
- p.Thr7Ile Single submitter ⚠
- p.Thr94Ile Single submitter ⚠
- p.Val104Glu Single submitter ⚠
- p.Val159Asp Single submitter ⚠
- p.Val187Ala Single submitter ⚠
- p.Val219Met Single submitter ⚠
- p.Val248Met Single submitter ⚠
- p.Val316Ala Single submitter ⚠
- p.Val389Met Single submitter ⚠
- p.Val42Met Single submitter ⚠