TEC — 50 ClinVar variants
All ClinVar germline TEC variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 49 flagged for review →
1 Likely pathogenic · 49 Uncertain significance
Full TEC gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 49
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 25
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEC p.Arg29Gly Uncertain significance Single submitter
- TEC p.Arg342Gln Uncertain significance Single submitter
- TEC p.Arg617Cys Uncertain significance Single submitter
- TEC p.Asn179Asp Uncertain significance Single submitter
- TEC p.Glu175Gln Uncertain significance Single submitter
- TEC p.Glu446Ala Uncertain significance Single submitter
- TEC p.Glu573Val Uncertain significance Single submitter
- TEC p.Gly142Arg Uncertain significance Single submitter
- TEC p.Gly269Ser Uncertain significance Single submitter
- TEC p.Gly448Asp Uncertain significance Single submitter
- TEC p.His318Pro Uncertain significance Single submitter
- TEC p.Ile619Met Uncertain significance Single submitter
- TEC p.Lys266Thr Uncertain significance Single submitter
- TEC p.Met555Ile Uncertain significance Single submitter
- TEC p.Pro168Leu Uncertain significance Single submitter
- TEC p.Ser255Asn Uncertain significance Single submitter
- TEC p.Thr126Lys Uncertain significance Single submitter
- TEC p.Thr21Ile Uncertain significance Single submitter
- TEC p.Thr39Ala Uncertain significance Single submitter
- TEC p.Trp389Arg Uncertain significance Single submitter
- TEC p.Tyr41Asp Uncertain significance Single submitter
- TEC p.Tyr479Ser Uncertain significance Single submitter
- TEC p.Val426Met Uncertain significance Single submitter
- TEC p.Val514Ile Uncertain significance Single submitter
- TEC p.Val71Ile Uncertain significance Single submitter
Predictors split 24
The independent predictors disagree with each other — read with care.
- TEC p.Ala500Val Uncertain significance Single submitter
- TEC p.Arg202Ser Uncertain significance Single submitter
- TEC p.Arg262Leu Uncertain significance Single submitter
- TEC p.Arg390Gln Uncertain significance Single submitter
- TEC p.Asn112Ile Uncertain significance Single submitter
- TEC p.Asn147Ile Uncertain significance Single submitter
- TEC p.Asn571Ser Uncertain significance Single submitter
- TEC p.Gln131Arg Uncertain significance Single submitter
- TEC p.His301Gln Uncertain significance Single submitter
- TEC p.His332Gln Uncertain significance Single submitter
- TEC p.Ile183Met Uncertain significance Single submitter
- TEC p.Ile411Thr Uncertain significance Single submitter
- TEC p.Ile59Val Uncertain significance Single submitter
- TEC p.Leu30Phe Uncertain significance Single submitter
- TEC p.Met555Val Uncertain significance Single submitter
- TEC p.Pro423Leu Uncertain significance Single submitter
- TEC p.Ser294Leu Uncertain significance Single submitter
- TEC p.Ser378Gly Uncertain significance Single submitter
- TEC p.Ser591Ala Uncertain significance Single submitter
- TEC p.Ser611Tyr Uncertain significance Single submitter
- TEC p.Thr34Arg Uncertain significance Single submitter
- TEC p.Thr570Ile Uncertain significance Single submitter
- TEC p.Tyr595Cys Uncertain significance Single submitter
- TEC p.Val214Phe Uncertain significance Single submitter
All TEC variants
Likely pathogenic 1
- c.496-1G>A Single submitter
Uncertain significance 49
- p.Ala500Val Single submitter ⚠
- p.Arg202Ser Single submitter ⚠
- p.Arg262Leu Single submitter ⚠
- p.Arg29Gly Single submitter ⚠
- p.Arg342Gln Single submitter ⚠
- p.Arg390Gln Single submitter ⚠
- p.Arg617Cys Single submitter ⚠
- p.Asn112Ile Single submitter ⚠
- p.Asn147Ile Single submitter ⚠
- p.Asn179Asp Single submitter ⚠
- p.Asn571Ser Single submitter ⚠
- p.Gln131Arg Single submitter ⚠
- p.Glu175Gln Single submitter ⚠
- p.Glu446Ala Single submitter ⚠
- p.Glu573Val Single submitter ⚠
- p.Gly142Arg Single submitter ⚠
- p.Gly269Ser Single submitter ⚠
- p.Gly448Asp Single submitter ⚠
- p.His301Gln Single submitter ⚠
- p.His318Pro Single submitter ⚠
- p.His332Gln Single submitter ⚠
- p.Ile183Met Single submitter ⚠
- p.Ile411Thr Single submitter ⚠
- p.Ile59Val Single submitter ⚠
- p.Ile619Met Single submitter ⚠
- p.Leu30Phe Single submitter ⚠
- p.Lys266Thr Single submitter ⚠
- p.Met555Ile Single submitter ⚠
- p.Met555Val Single submitter ⚠
- p.Pro168Leu Single submitter ⚠
- p.Pro423Leu Single submitter ⚠
- p.Ser255Asn Single submitter ⚠
- p.Ser294Leu Single submitter ⚠
- p.Ser378Gly Single submitter ⚠
- p.Ser591Ala Single submitter ⚠
- p.Ser611Tyr Single submitter ⚠
- p.Thr126Lys Single submitter ⚠
- p.Thr21Ile Single submitter ⚠
- p.Thr34Arg Single submitter ⚠
- p.Thr39Ala Single submitter ⚠
- p.Thr570Ile Single submitter ⚠
- p.Trp389Arg Single submitter ⚠
- p.Tyr41Asp Single submitter ⚠
- p.Tyr479Ser Single submitter ⚠
- p.Tyr595Cys Single submitter ⚠
- p.Val214Phe Single submitter ⚠
- p.Val426Met Single submitter ⚠
- p.Val514Ile Single submitter ⚠
- p.Val71Ile Single submitter ⚠