TECTA — 123 ClinVar variants
All ClinVar germline TECTA variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 52 flagged for review →
8 Pathogenic · 6 Pathogenic/Likely pathogenic · 10 Likely pathogenic · 29 Conflicting · 7 Benign · 4 Benign/Likely benign · 3 Likely benign · 56 Uncertain significance
Full TECTA gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 52
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors vs ClinVar 1
ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.
-
TECTA p.Ala872Ser
Likely pathogenic
Single submitter
autosomal recessive nonsyndromic hearing loss 21
Predictors agree, ClinVar conflicts 9
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
-
TECTA p.Ala1341Thr
Conflicting
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Ile1574Val
Conflicting
Single submitter
Inborn genetic diseases
-
TECTA p.Leu943Met
Conflicting
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Ser2143Leu
Conflicting
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Thr190Met
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Val1171Met
Conflicting
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Val1494Ala
Conflicting
Single submitter
Meniere disease
-
TECTA p.Val1605Ile
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Val2026Ile
Conflicting
Single submitter
Inborn genetic diseases
Predictors lean, ClinVar uncertain 27
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
-
TECTA p.Ala567Thr
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Cys1285Ser
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Cys1402Ser
Uncertain significance
Multiple submitters
Meniere disease
-
TECTA p.Cys294Arg
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Leu27Pro
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Met206Thr
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Pro119Ala
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Ser1481Gly
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Ser599Thr
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
TECTA p.Val1207Met
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Val1634Ala
Uncertain significance
Multiple submitters
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Arg2101Trp
Uncertain significance
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Arg284His
Uncertain significance
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Asp42Glu
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Asp505His
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Cys2052Arg
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Cys671Tyr
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Gly201Ser
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
- TECTA p.Gly2078Glu Uncertain significance Single submitter
-
TECTA p.Leu564Phe
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Lys1726Asn
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Lys1754Glu
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Phe178Cys
Uncertain significance
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Phe439Ser
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Phe87Cys
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Ser2120Thr
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Thr1129Arg
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
Predictors split 15
The independent predictors disagree with each other — read with care.
-
TECTA p.Arg284Cys
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
TECTA p.Arg474Cys
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Gln1862Arg
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Ile1997Thr
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
TECTA p.Met1697Ile
Uncertain significance
Multiple submitters
Inborn genetic diseases
-
TECTA p.Thr1446Arg
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Tyr1705Cys
Uncertain significance
Multiple submitters
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Arg1186Trp
Conflicting
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Arg1462Cys
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Arg909Cys
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 12
- TECTA p.Leu1953Ser Uncertain significance Single submitter
-
TECTA p.Pro1914Arg
Uncertain significance
Single submitter
autosomal recessive nonsyndromic hearing loss 21
-
TECTA p.Ser1644Arg
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Thr126Ile
Uncertain significance
Single submitter
autosomal dominant nonsyndromic hearing loss 12
-
TECTA p.Thr815Met
Conflicting
Single submitter
autosomal dominant nonsyndromic hearing loss 12
All TECTA variants
Pathogenic 8
- p.Trp1362Ter Expert panel nonsyndromic genetic hearing loss
- p.Arg1174Ter Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Cys1619Ter Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Gln569Ter Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Glu1021delinsLysSerLeuAsnGlnGlyArgSerSerGlyValGluArgValValSerTer Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Leu1005fs Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Arg1956Ter No assertion criteria autosomal recessive nonsyndromic hearing loss 21
- p.Cys1837Gly No assertion criteria autosomal dominant nonsyndromic hearing loss 12
Pathogenic/Likely pathogenic 6
- c.4690-1G>A Multiple submitters autosomal dominant nonsyndromic hearing loss 12
- p.Arg2021Cys Multiple submitters autosomal dominant nonsyndromic hearing loss 12
- p.Asp2006Gly Multiple submitters TECTA-related disorder
- p.Gly109= Multiple submitters TECTA-related disorder
- p.Ser373fs Multiple submitters TECTA-related disorder
- p.Gly416fs No assertion criteria autosomal recessive nonsyndromic hearing loss 21
Likely pathogenic 10
- c.2367+2T>C Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Ala872Ser Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Cys1837Arg Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Gly434Val Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Gly579fs Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Leu1777= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Lys820Ter Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Ser1847Pro Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Ser5fs Single submitter nonsyndromic genetic hearing loss
- p.Thr190Pro Single submitter autosomal dominant nonsyndromic hearing loss 12
Conflicting classifications of pathogenicity 29
- c.2367+9C>T Single submitter autosomal recessive nonsyndromic hearing loss 21
- c.5586+12A>G Single submitter autosomal dominant nonsyndromic hearing loss 12
- c.625-4G>T Single submitter
- c.65-14A>G Single submitter autosomal recessive nonsyndromic hearing loss 21
- c.790+12C>T Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Ala1046= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Ala1341Thr Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Ala1735= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Arg1186Trp Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Arg909Cys Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Asn238= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Cys2045= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Gly1042= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Gly1655= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Ile1574Val Single submitter Inborn genetic diseases ⚠
- p.Leu1959= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Leu943Met Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Phe1511= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Pro30= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Ser140= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Ser2143Leu Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Ser362Ile Single submitter Inborn genetic diseases
- p.Thr190Met Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Thr815Met Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Tyr1714= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Val1171Met Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Val1494Ala Single submitter Meniere disease ⚠
- p.Val1605Ile Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Val2026Ile Single submitter Inborn genetic diseases ⚠
Benign 7
- p.Arg371Gly Expert panel nonsyndromic genetic hearing loss
- c.4105+13C>T Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- c.5272+26A>G Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- c.5586+40C>G Multiple submitters autosomal dominant nonsyndromic hearing loss 12
- p.Ala495= Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Ser1724Asn Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Ser1878= Multiple submitters autosomal recessive nonsyndromic hearing loss 21
Benign/Likely benign 4
- c.624+11C>G Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Ser1584Thr Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Val1911= Multiple submitters autosomal recessive nonsyndromic hearing loss 21
- p.Val932Ala Multiple submitters autosomal recessive nonsyndromic hearing loss 21
Likely benign 3
- c.487-7C>G Expert panel nonsyndromic genetic hearing loss
- p.Gly1335Glu Expert panel nonsyndromic genetic hearing loss
- p.Trp10Ser Single submitter autosomal dominant nonsyndromic hearing loss 12
Uncertain significance 56
- p.Ala567Thr Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Arg284Cys Multiple submitters Inborn genetic diseases ⚠
- p.Arg474Cys Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Cys1072= Multiple submitters autosomal dominant nonsyndromic hearing loss 12
- p.Cys1285Ser Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Cys1402Ser Multiple submitters Meniere disease ⚠
- p.Cys294Arg Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Gln1862Arg Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Ile1997Thr Multiple submitters Inborn genetic diseases ⚠
- p.Leu27Pro Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Met1697Ile Multiple submitters Inborn genetic diseases ⚠
- p.Met206Thr Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Pro119Ala Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Ser1481Gly Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Ser599Thr Multiple submitters Inborn genetic diseases ⚠
- p.Thr1446Arg Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Tyr1705Cys Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Val1207Met Multiple submitters autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Val1634Ala Multiple submitters autosomal dominant nonsyndromic hearing loss 12 ⚠
- c.2941+3366T>G Single submitter autosomal recessive nonsyndromic hearing loss 21
- c.4977-12C>T Single submitter autosomal recessive nonsyndromic hearing loss 21
- c.5587-15C>G Single submitter autosomal recessive nonsyndromic hearing loss 21
- c.790+4A>G Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Arg1462Cys Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Arg2101Trp Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Arg284His Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Asp1430Gly Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Asp42Glu Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Asp505His Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Asp725= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Cys2052Arg Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Cys671Tyr Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Gly1113Ala Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Gly201Ser Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Gly2078Glu Single submitter ⚠
- p.His2023= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Ile254= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Leu1953Ser Single submitter ⚠
- p.Leu564Phe Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Lys1726Asn Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Lys1754Glu Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Met1811del Single submitter nonsyndromic genetic hearing loss
- p.Phe178Cys Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Phe439Ser Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Phe87Cys Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Pro1914Arg Single submitter autosomal recessive nonsyndromic hearing loss 21 ⚠
- p.Ser1644Arg Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Ser2120Thr Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Ser47Cys Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Ser593= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Thr1129Arg Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Thr126Ile Single submitter autosomal dominant nonsyndromic hearing loss 12 ⚠
- p.Thr1354Ser Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Thr1971= Single submitter autosomal recessive nonsyndromic hearing loss 21
- p.Tyr2050= Single submitter autosomal dominant nonsyndromic hearing loss 12
- p.Val363= Single submitter autosomal dominant nonsyndromic hearing loss 12