TEKT1 — 76 ClinVar variants
All ClinVar germline TEKT1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 68 flagged for review →
4 Likely benign · 72 Uncertain significance
Full TEKT1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 68
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 52
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TEKT1 p.Ala140Ser Uncertain significance Single submitter
- TEKT1 p.Ala204Thr Uncertain significance Single submitter
- TEKT1 p.Ala240Val Uncertain significance Single submitter
- TEKT1 p.Ala333Thr Uncertain significance Single submitter
- TEKT1 p.Ala349Thr Uncertain significance Single submitter
- TEKT1 p.Arg244Gln Uncertain significance Single submitter
- TEKT1 p.Arg254His Uncertain significance Single submitter
- TEKT1 p.Arg31Lys Uncertain significance Single submitter
- TEKT1 p.Arg323Gln Uncertain significance Single submitter
- TEKT1 p.Arg323Trp Uncertain significance Single submitter
- TEKT1 p.Arg33Gln Uncertain significance Single submitter
- TEKT1 p.Arg33Leu Uncertain significance Single submitter
- TEKT1 p.Arg367His Uncertain significance Single submitter
- TEKT1 p.Arg36His Uncertain significance Single submitter
- TEKT1 p.Arg400Gln Uncertain significance Single submitter
- TEKT1 p.Arg400Trp Uncertain significance Single submitter
- TEKT1 p.Asn203Tyr Uncertain significance Single submitter
- TEKT1 p.Asp177Val Uncertain significance Single submitter
- TEKT1 p.Asp186Gly Uncertain significance Single submitter
- TEKT1 p.Asp216Glu Uncertain significance Single submitter
- TEKT1 p.Asp280Asn Uncertain significance Single submitter
- TEKT1 p.Asp386Val Uncertain significance Single submitter
- TEKT1 p.Asp401Val Uncertain significance Single submitter
- TEKT1 p.Cys418Arg Uncertain significance Single submitter
- TEKT1 p.Gln144Glu Uncertain significance Single submitter
- TEKT1 p.Gln23His Uncertain significance Single submitter
- TEKT1 p.Gln306Lys Uncertain significance Single submitter
- TEKT1 p.Gln30Glu Uncertain significance Single submitter
- TEKT1 p.Gln392Lys Uncertain significance Single submitter
- TEKT1 p.Glu215Lys Uncertain significance Single submitter
- TEKT1 p.Glu82Ala Uncertain significance Single submitter
- TEKT1 p.Gly145Ser Uncertain significance Single submitter
- TEKT1 p.Gly402Arg Uncertain significance Single submitter
- TEKT1 p.His129Arg Uncertain significance Single submitter
- TEKT1 p.His314Gln Uncertain significance Single submitter
- TEKT1 p.His405Arg Uncertain significance Single submitter
- TEKT1 p.Ile123Phe Uncertain significance Single submitter
- TEKT1 p.Ile207Thr Uncertain significance Single submitter
- TEKT1 p.Leu218Ser Uncertain significance Single submitter
- TEKT1 p.Leu268Pro Uncertain significance Single submitter
- TEKT1 p.Leu370Arg Uncertain significance Single submitter
- TEKT1 p.Pro7Ser Uncertain significance Single submitter
- TEKT1 p.Pro9Ser Uncertain significance Single submitter
- TEKT1 p.Thr223Ile Uncertain significance Single submitter
- TEKT1 p.Thr262Met Uncertain significance Single submitter
- TEKT1 p.Thr51Ile Uncertain significance Single submitter
- TEKT1 p.Val212Leu Uncertain significance Single submitter
- TEKT1 p.Val225Met Uncertain significance Single submitter
- TEKT1 p.Val285Ile Uncertain significance Single submitter
- TEKT1 p.Val326Leu Uncertain significance Single submitter
- TEKT1 p.Val417Leu Uncertain significance Single submitter
- TEKT1 p.Val45Met Uncertain significance Single submitter
Predictors split 16
The independent predictors disagree with each other — read with care.
- TEKT1 p.Arg152Cys Uncertain significance Single submitter
- TEKT1 p.Arg31Met Uncertain significance Single submitter
- TEKT1 p.Arg330Cys Uncertain significance Single submitter
- TEKT1 p.Asn193Asp Uncertain significance Single submitter
- TEKT1 p.Glu159Lys Uncertain significance Single submitter
- TEKT1 p.Glu288Gly Uncertain significance Single submitter
- TEKT1 p.Glu293Lys Uncertain significance Single submitter
- TEKT1 p.Leu154Phe Uncertain significance Single submitter
- TEKT1 p.Leu328Arg Uncertain significance Single submitter
- TEKT1 p.Lys138Asn Uncertain significance Single submitter
- TEKT1 p.Pro324Leu Uncertain significance Single submitter
- TEKT1 p.Thr249Ile Uncertain significance Single submitter
- TEKT1 p.Thr345Ile Uncertain significance Single submitter
- TEKT1 p.Val70Ala Uncertain significance Single submitter
-
TEKT1 p.Asp273Gly
Likely benign
No assertion criteria
TEKT1-related disorder
-
TEKT1 p.Lys311Asn
Likely benign
No assertion criteria
TEKT1-related disorder
All TEKT1 variants
Likely benign 4
- c.357-10C>A Single submitter
- p.Asn251Ser Single submitter
- p.Asp273Gly No assertion criteria TEKT1-related disorder ⚠
- p.Lys311Asn No assertion criteria TEKT1-related disorder ⚠
Uncertain significance 72
- p.Ala140Ser Single submitter ⚠
- p.Ala204Thr Single submitter ⚠
- p.Ala240Val Single submitter ⚠
- p.Ala333Thr Single submitter ⚠
- p.Ala349Thr Single submitter ⚠
- p.Arg122Cys Single submitter
- p.Arg122His Single submitter
- p.Arg152Cys Single submitter ⚠
- p.Arg162Trp Single submitter
- p.Arg165Cys Single submitter
- p.Arg244Gln Single submitter ⚠
- p.Arg254His Single submitter ⚠
- p.Arg31Lys Single submitter ⚠
- p.Arg31Met Single submitter ⚠
- p.Arg323Gln Single submitter ⚠
- p.Arg323Trp Single submitter ⚠
- p.Arg330Cys Single submitter ⚠
- p.Arg33Gln Single submitter ⚠
- p.Arg33Leu Single submitter ⚠
- p.Arg367His Single submitter ⚠
- p.Arg36His Single submitter ⚠
- p.Arg400Gln Single submitter ⚠
- p.Arg400Trp Single submitter ⚠
- p.Asn193Asp Single submitter ⚠
- p.Asn203Tyr Single submitter ⚠
- p.Asp177Val Single submitter ⚠
- p.Asp186Gly Single submitter ⚠
- p.Asp216Glu Single submitter ⚠
- p.Asp280Asn Single submitter ⚠
- p.Asp386Val Single submitter ⚠
- p.Asp401Val Single submitter ⚠
- p.Cys418Arg Single submitter ⚠
- p.Gln144Glu Single submitter ⚠
- p.Gln23His Single submitter ⚠
- p.Gln306Lys Single submitter ⚠
- p.Gln30Glu Single submitter ⚠
- p.Gln392Lys Single submitter ⚠
- p.Glu159Lys Single submitter ⚠
- p.Glu215Lys Single submitter ⚠
- p.Glu288Gly Single submitter ⚠
- p.Glu293Lys Single submitter ⚠
- p.Glu82Ala Single submitter ⚠
- p.Gly145Ser Single submitter ⚠
- p.Gly402Arg Single submitter ⚠
- p.His129Arg Single submitter ⚠
- p.His314Gln Single submitter ⚠
- p.His405Arg Single submitter ⚠
- p.Ile123Phe Single submitter ⚠
- p.Ile207Thr Single submitter ⚠
- p.Leu136Met Single submitter
- p.Leu154Phe Single submitter ⚠
- p.Leu218Ser Single submitter ⚠
- p.Leu268Pro Single submitter ⚠
- p.Leu328Arg Single submitter ⚠
- p.Leu370Arg Single submitter ⚠
- p.Lys138Asn Single submitter ⚠
- p.Pro324Leu Single submitter ⚠
- p.Pro7Ser Single submitter ⚠
- p.Pro9Ser Single submitter ⚠
- p.Thr223Ile Single submitter ⚠
- p.Thr249Ile Single submitter ⚠
- p.Thr262Met Single submitter ⚠
- p.Thr315Arg Single submitter
- p.Thr345Ile Single submitter ⚠
- p.Thr51Ile Single submitter ⚠
- p.Val212Leu Single submitter ⚠
- p.Val225Met Single submitter ⚠
- p.Val285Ile Single submitter ⚠
- p.Val326Leu Single submitter ⚠
- p.Val417Leu Single submitter ⚠
- p.Val45Met Single submitter ⚠
- p.Val70Ala Single submitter ⚠