TES — 41 ClinVar variants
All ClinVar germline TES variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 39 flagged for review →
41 Uncertain significance
Full TES gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 39
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 32
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TES p.Ala186Val Uncertain significance Single submitter
- TES p.Ala227Thr Uncertain significance Single submitter
- TES p.Ala77Thr Uncertain significance Single submitter
- TES p.Arg374Trp Uncertain significance Single submitter
- TES p.Arg89Cys Uncertain significance Single submitter
- TES p.Asn107Asp Uncertain significance Single submitter
- TES p.Asp82Gly Uncertain significance Single submitter
- TES p.Cys46Arg Uncertain significance Single submitter
- TES p.Gln144Arg Uncertain significance Single submitter
- TES p.Glu415Ala Uncertain significance Single submitter
- TES p.Gly13Ala Uncertain significance Single submitter
- TES p.Gly256Asp Uncertain significance Single submitter
- TES p.Gly31Arg Uncertain significance Single submitter
- TES p.Ile250Val Uncertain significance Single submitter
- TES p.Leu54Pro Uncertain significance Single submitter
- TES p.Leu55Phe Uncertain significance Single submitter
- TES p.Lys101Arg Uncertain significance Single submitter
- TES p.Lys286Asn Uncertain significance Single submitter
- TES p.Met222Thr Uncertain significance Single submitter
- TES p.Met222Val Uncertain significance Single submitter
-
TES p.Phe389Ser
Uncertain significance
Single submitter
hereditary breast ovarian cancer syndrome
- TES p.Pro116Ser Uncertain significance Single submitter
- TES p.Pro209Ser Uncertain significance Single submitter
- TES p.Ser140Leu Uncertain significance Single submitter
- TES p.Ser162Leu Uncertain significance Single submitter
- TES p.Thr270Ile Uncertain significance Single submitter
- TES p.Tyr237Cys Uncertain significance Single submitter
- TES p.Val192Ile Uncertain significance Single submitter
- TES p.Val348Met Uncertain significance Single submitter
- TES p.Val354Met Uncertain significance Single submitter
- TES p.Val53Ile Uncertain significance Single submitter
- TES p.Val98Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TES p.Ala384Thr Uncertain significance Single submitter
- TES p.Asp345Tyr Uncertain significance Single submitter
- TES p.Glu33Val Uncertain significance Single submitter
- TES p.Lys45Glu Uncertain significance Single submitter
- TES p.Phe329Leu Uncertain significance Single submitter
- TES p.Pro405Leu Uncertain significance Single submitter
- TES p.Tyr377Cys Uncertain significance Single submitter
All TES variants
Uncertain significance 41
- p.Ala186Val Single submitter ⚠
- p.Ala227Thr Single submitter ⚠
- p.Ala384Thr Single submitter ⚠
- p.Ala77Thr Single submitter ⚠
- p.Arg374Trp Single submitter ⚠
- p.Arg89Cys Single submitter ⚠
- p.Asn107Asp Single submitter ⚠
- p.Asp345Tyr Single submitter ⚠
- p.Asp82Ala Single submitter
- p.Asp82Gly Single submitter ⚠
- p.Cys46Arg Single submitter ⚠
- p.Gln144Arg Single submitter ⚠
- p.Glu33Val Single submitter ⚠
- p.Glu415Ala Single submitter ⚠
- p.Gly13Ala Single submitter ⚠
- p.Gly246Ala Single submitter
- p.Gly256Asp Single submitter ⚠
- p.Gly31Arg Single submitter ⚠
- p.Ile250Val Single submitter ⚠
- p.Leu54Pro Single submitter ⚠
- p.Leu55Phe Single submitter ⚠
- p.Lys101Arg Single submitter ⚠
- p.Lys286Asn Single submitter ⚠
- p.Lys45Glu Single submitter ⚠
- p.Met222Thr Single submitter ⚠
- p.Met222Val Single submitter ⚠
- p.Phe329Leu Single submitter ⚠
- p.Phe389Ser Single submitter hereditary breast ovarian cancer syndrome ⚠
- p.Pro116Ser Single submitter ⚠
- p.Pro209Ser Single submitter ⚠
- p.Pro405Leu Single submitter ⚠
- p.Ser140Leu Single submitter ⚠
- p.Ser162Leu Single submitter ⚠
- p.Thr270Ile Single submitter ⚠
- p.Tyr237Cys Single submitter ⚠
- p.Tyr377Cys Single submitter ⚠
- p.Val192Ile Single submitter ⚠
- p.Val348Met Single submitter ⚠
- p.Val354Met Single submitter ⚠
- p.Val53Ile Single submitter ⚠
- p.Val98Ile Single submitter ⚠