TESK1 — 76 ClinVar variants
All ClinVar germline TESK1 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 74 flagged for review →
2 Likely benign · 74 Uncertain significance
Full TESK1 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 74
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TESK1 p.Ala238Val Uncertain significance Single submitter
- TESK1 p.Ala322Val Uncertain significance Single submitter
- TESK1 p.Ala337Thr Uncertain significance Single submitter
- TESK1 p.Ala459Thr Uncertain significance Single submitter
- TESK1 p.Ala491Ser Uncertain significance Single submitter
- TESK1 p.Ala520Pro Uncertain significance Single submitter
- TESK1 p.Ala520Thr Uncertain significance Single submitter
- TESK1 p.Ala544Val Uncertain significance Single submitter
- TESK1 p.Ala601Val Uncertain significance Single submitter
- TESK1 p.Arg164Trp Uncertain significance Single submitter
- TESK1 p.Arg174His Uncertain significance Single submitter
- TESK1 p.Arg433Cys Uncertain significance Single submitter
- TESK1 p.Arg434Cys Uncertain significance Single submitter
- TESK1 p.Arg434His Uncertain significance Single submitter
- TESK1 p.Arg436Cys Uncertain significance Single submitter
- TESK1 p.Arg436His Uncertain significance Single submitter
- TESK1 p.Arg543Trp Uncertain significance Single submitter
- TESK1 p.Arg549Gln Uncertain significance Single submitter
- TESK1 p.Arg549Trp Uncertain significance Single submitter
- TESK1 p.Arg560Gln Uncertain significance Single submitter
- TESK1 p.Arg586Cys Uncertain significance Single submitter
- TESK1 p.Arg593His Uncertain significance Single submitter
- TESK1 p.Arg595Cys Uncertain significance Single submitter
- TESK1 p.Arg608Gln Uncertain significance Single submitter
- TESK1 p.Arg625His Uncertain significance Single submitter
- TESK1 p.Asn517Ser Uncertain significance Single submitter
- TESK1 p.Asp187His Uncertain significance Single submitter
- TESK1 p.Asp270Gly Uncertain significance Single submitter
- TESK1 p.Asp373Asn Uncertain significance Single submitter
- TESK1 p.Asp563Asn Uncertain significance Single submitter
- TESK1 p.Asp563Gly Uncertain significance Single submitter
- TESK1 p.Gln122Arg Uncertain significance Single submitter
- TESK1 p.Gln415His Uncertain significance Single submitter
- TESK1 p.Glu145Ala Uncertain significance Single submitter
- TESK1 p.Glu443Lys Uncertain significance Single submitter
- TESK1 p.Glu469Gln Uncertain significance Single submitter
- TESK1 p.Glu476Gln Uncertain significance Single submitter
- TESK1 p.Gly454Ser Uncertain significance Single submitter
- TESK1 p.His310Asp Uncertain significance Single submitter
- TESK1 p.Met116Val Uncertain significance Single submitter
- TESK1 p.Pro214Leu Uncertain significance Single submitter
- TESK1 p.Pro323Ser Uncertain significance Single submitter
- TESK1 p.Pro341Ser Uncertain significance Single submitter
- TESK1 p.Pro346Ser Uncertain significance Single submitter
- TESK1 p.Pro363Leu Uncertain significance Single submitter
- TESK1 p.Pro369Arg Uncertain significance Single submitter
- TESK1 p.Pro422Leu Uncertain significance Single submitter
- TESK1 p.Pro457Ser Uncertain significance Single submitter
- TESK1 p.Pro477Leu Uncertain significance Single submitter
- TESK1 p.Pro487Leu Uncertain significance Single submitter
- TESK1 p.Pro518Ala Uncertain significance Single submitter
- TESK1 p.Pro552Arg Uncertain significance Single submitter
- TESK1 p.Pro556Ala Uncertain significance Single submitter
- TESK1 p.Ser148Pro Uncertain significance Single submitter
- TESK1 p.Ser299Asn Uncertain significance Single submitter
- TESK1 p.Ser463Leu Uncertain significance Single submitter
- TESK1 p.Ser501Leu Uncertain significance Single submitter
- TESK1 p.Ser540Asn Uncertain significance Single submitter
- TESK1 p.Thr344Met Uncertain significance Single submitter
- TESK1 p.Thr421Ile Uncertain significance Single submitter
- TESK1 p.Thr492Ala Uncertain significance Single submitter
- TESK1 p.Thr616Ile Uncertain significance Single submitter
- TESK1 p.Trp371Ser Uncertain significance Single submitter
- TESK1 p.Val151Ile Uncertain significance Single submitter
- TESK1 p.Val218Met Uncertain significance Single submitter
- TESK1 p.Val402Ile Uncertain significance Single submitter
- TESK1 p.Val513Ile Uncertain significance Single submitter
Predictors split 7
The independent predictors disagree with each other — read with care.
- TESK1 p.Arg184Gln Uncertain significance Single submitter
- TESK1 p.Asp386Glu Uncertain significance Single submitter
- TESK1 p.Glu312Lys Uncertain significance Single submitter
- TESK1 p.Gly574Arg Uncertain significance Single submitter
- TESK1 p.Ile496Thr Uncertain significance Single submitter
- TESK1 p.Pro150Leu Uncertain significance Single submitter
- TESK1 p.Pro569Leu Uncertain significance Single submitter
All TESK1 variants
Likely benign 2
- p.Arg188Gln Single submitter
- p.Arg275Ter No assertion criteria EBV-positive nodal T- and NK-cell lymphoma
Uncertain significance 74
- p.Ala238Val Single submitter ⚠
- p.Ala322Val Single submitter ⚠
- p.Ala337Thr Single submitter ⚠
- p.Ala459Thr Single submitter ⚠
- p.Ala491Ser Single submitter ⚠
- p.Ala520Pro Single submitter ⚠
- p.Ala520Thr Single submitter ⚠
- p.Ala544Val Single submitter ⚠
- p.Ala601Val Single submitter ⚠
- p.Arg164Trp Single submitter ⚠
- p.Arg174His Single submitter ⚠
- p.Arg184Gln Single submitter ⚠
- p.Arg433Cys Single submitter ⚠
- p.Arg434Cys Single submitter ⚠
- p.Arg434His Single submitter ⚠
- p.Arg436Cys Single submitter ⚠
- p.Arg436His Single submitter ⚠
- p.Arg543Trp Single submitter ⚠
- p.Arg549Gln Single submitter ⚠
- p.Arg549Trp Single submitter ⚠
- p.Arg560Gln Single submitter ⚠
- p.Arg586Cys Single submitter ⚠
- p.Arg593His Single submitter ⚠
- p.Arg595Cys Single submitter ⚠
- p.Arg608Gln Single submitter ⚠
- p.Arg625His Single submitter ⚠
- p.Asn517Ser Single submitter ⚠
- p.Asp187His Single submitter ⚠
- p.Asp270Gly Single submitter ⚠
- p.Asp373Asn Single submitter ⚠
- p.Asp386Glu Single submitter ⚠
- p.Asp563Asn Single submitter ⚠
- p.Asp563Gly Single submitter ⚠
- p.Gln122Arg Single submitter ⚠
- p.Gln415His Single submitter ⚠
- p.Glu145Ala Single submitter ⚠
- p.Glu312Lys Single submitter ⚠
- p.Glu443Lys Single submitter ⚠
- p.Glu469Gln Single submitter ⚠
- p.Glu476Gln Single submitter ⚠
- p.Gly454Ser Single submitter ⚠
- p.Gly574Arg Single submitter ⚠
- p.His310Asp Single submitter ⚠
- p.Ile496Thr Single submitter ⚠
- p.Met116Val Single submitter ⚠
- p.Pro150Leu Single submitter ⚠
- p.Pro214Leu Single submitter ⚠
- p.Pro323Ser Single submitter ⚠
- p.Pro341Ser Single submitter ⚠
- p.Pro346Ser Single submitter ⚠
- p.Pro363Leu Single submitter ⚠
- p.Pro369Arg Single submitter ⚠
- p.Pro422Leu Single submitter ⚠
- p.Pro457Ser Single submitter ⚠
- p.Pro477Leu Single submitter ⚠
- p.Pro487Leu Single submitter ⚠
- p.Pro518Ala Single submitter ⚠
- p.Pro552Arg Single submitter ⚠
- p.Pro556Ala Single submitter ⚠
- p.Pro569Leu Single submitter ⚠
- p.Ser148Pro Single submitter ⚠
- p.Ser299Asn Single submitter ⚠
- p.Ser463Leu Single submitter ⚠
- p.Ser501Leu Single submitter ⚠
- p.Ser540Asn Single submitter ⚠
- p.Thr344Met Single submitter ⚠
- p.Thr421Ile Single submitter ⚠
- p.Thr492Ala Single submitter ⚠
- p.Thr616Ile Single submitter ⚠
- p.Trp371Ser Single submitter ⚠
- p.Val151Ile Single submitter ⚠
- p.Val218Met Single submitter ⚠
- p.Val402Ile Single submitter ⚠
- p.Val513Ile Single submitter ⚠