TESK2 — 87 ClinVar variants
All ClinVar germline TESK2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 79 flagged for review →
1 Benign · 3 Likely benign · 83 Uncertain significance
Full TESK2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 79
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 67
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TESK2 p.Ala393Thr Uncertain significance Single submitter
- TESK2 p.Ala394Gly Uncertain significance Single submitter
- TESK2 p.Ala509Thr Uncertain significance Single submitter
- TESK2 p.Ala512Thr Uncertain significance Single submitter
- TESK2 p.Ala79Gly Uncertain significance Single submitter
- TESK2 p.Arg18Cys Uncertain significance Single submitter
- TESK2 p.Arg18Gly Uncertain significance Single submitter
- TESK2 p.Arg332Ser Uncertain significance Single submitter
- TESK2 p.Arg332Thr Uncertain significance Single submitter
- TESK2 p.Arg343Gln Uncertain significance Single submitter
- TESK2 p.Arg360His Uncertain significance Single submitter
- TESK2 p.Arg374Cys Uncertain significance Single submitter
- TESK2 p.Arg374His Uncertain significance Single submitter
- TESK2 p.Arg378Cys Uncertain significance Single submitter
- TESK2 p.Arg378Gly Uncertain significance Single submitter
- TESK2 p.Arg378His Uncertain significance Single submitter
- TESK2 p.Arg395His Uncertain significance Single submitter
- TESK2 p.Arg452Cys Uncertain significance Single submitter
- TESK2 p.Arg452His Uncertain significance Single submitter
- TESK2 p.Arg453Gln Uncertain significance Single submitter
- TESK2 p.Arg455His Uncertain significance Single submitter
- TESK2 p.Arg474Gln Uncertain significance Single submitter
- TESK2 p.Arg500Gln Uncertain significance Single submitter
- TESK2 p.Arg500Trp Uncertain significance Single submitter
- TESK2 p.Arg55Cys Uncertain significance Single submitter
- TESK2 p.Arg76Gln Uncertain significance Single submitter
- TESK2 p.Arg78Gln Uncertain significance Single submitter
- TESK2 p.Arg95Trp Uncertain significance Single submitter
- TESK2 p.Asn106Lys Uncertain significance Single submitter
- TESK2 p.Asn265Asp Uncertain significance Single submitter
- TESK2 p.Asp206Asn Uncertain significance Single submitter
- TESK2 p.Gln317Lys Uncertain significance Single submitter
- TESK2 p.Glu188Lys Uncertain significance Single submitter
- TESK2 p.Glu29Lys Uncertain significance Single submitter
- TESK2 p.Glu310Asp Uncertain significance Single submitter
- TESK2 p.Glu320Asp Uncertain significance Single submitter
- TESK2 p.Gly136Arg Uncertain significance Single submitter
- TESK2 p.Gly436Arg Uncertain significance Single submitter
- TESK2 p.Gly523Ala Uncertain significance Single submitter
- TESK2 p.Gly567Arg Uncertain significance Single submitter
- TESK2 p.Ile160Val Uncertain significance Single submitter
- TESK2 p.Ile249Leu Uncertain significance Single submitter
- TESK2 p.Leu344Pro Uncertain significance Single submitter
- TESK2 p.Lys180Thr Uncertain significance Single submitter
- TESK2 p.Lys185Arg Uncertain significance Single submitter
- TESK2 p.Lys213Arg Uncertain significance Single submitter
- TESK2 p.Met117Val Uncertain significance Single submitter
- TESK2 p.Met438Thr Uncertain significance Single submitter
- TESK2 p.Met84Ile Uncertain significance Single submitter
- TESK2 p.Met84Thr Uncertain significance Single submitter
- TESK2 p.Phe463Ile Uncertain significance Single submitter
- TESK2 p.Phe556Leu Uncertain significance Single submitter
- TESK2 p.Pro13Ser Uncertain significance Single submitter
- TESK2 p.Pro232Ala Uncertain significance Single submitter
- TESK2 p.Pro40Ser Uncertain significance Single submitter
- TESK2 p.Pro470Leu Uncertain significance Single submitter
- TESK2 p.Ser179Pro Uncertain significance Single submitter
- TESK2 p.Ser460Leu Uncertain significance Single submitter
- TESK2 p.Ser477Leu Uncertain significance Single submitter
- TESK2 p.Ser559Leu Uncertain significance Single submitter
- TESK2 p.Thr361Ser Uncertain significance Single submitter
- TESK2 p.Thr396Ile Uncertain significance Single submitter
- TESK2 p.Tyr132Cys Uncertain significance Single submitter
- TESK2 p.Tyr259Cys Uncertain significance Single submitter
- TESK2 p.Val154Leu Uncertain significance Single submitter
- TESK2 p.Val382Ile Uncertain significance Single submitter
- TESK2 p.Val544Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TESK2 p.Arg360Cys Uncertain significance Single submitter
- TESK2 p.Arg6Trp Uncertain significance Single submitter
- TESK2 p.Ile160Thr Uncertain significance Single submitter
- TESK2 p.Ile244Val Uncertain significance Single submitter
- TESK2 p.Ile9Thr Uncertain significance Single submitter
- TESK2 p.Leu114Val Uncertain significance Single submitter
- TESK2 p.Met117Thr Uncertain significance Single submitter
- TESK2 p.Met88Ile Uncertain significance Single submitter
- TESK2 p.Pro329Leu Uncertain significance Single submitter
- TESK2 p.Ser135Phe Uncertain significance Single submitter
- TESK2 p.Ser42Leu Uncertain significance Single submitter
- TESK2 p.Tyr43Cys Uncertain significance Single submitter
All TESK2 variants
Benign 1
- p.Arg455Cys Multiple submitters
Likely benign 3
- p.Ala536Val Single submitter
- p.Arg315His Single submitter
- p.Arg485His Single submitter
Uncertain significance 83
- p.Ala393Thr Single submitter ⚠
- p.Ala394Gly Single submitter ⚠
- p.Ala509Thr Single submitter ⚠
- p.Ala512Thr Single submitter ⚠
- p.Ala79Gly Single submitter ⚠
- p.Arg18Cys Single submitter ⚠
- p.Arg18Gly Single submitter ⚠
- p.Arg332Ser Single submitter ⚠
- p.Arg332Thr Single submitter ⚠
- p.Arg343Gln Single submitter ⚠
- p.Arg360Cys Single submitter ⚠
- p.Arg360His Single submitter ⚠
- p.Arg374Cys Single submitter ⚠
- p.Arg374His Single submitter ⚠
- p.Arg378Cys Single submitter ⚠
- p.Arg378Gly Single submitter ⚠
- p.Arg378His Single submitter ⚠
- p.Arg395His Single submitter ⚠
- p.Arg452Cys Single submitter ⚠
- p.Arg452His Single submitter ⚠
- p.Arg453Gln Single submitter ⚠
- p.Arg455His Single submitter ⚠
- p.Arg474Gln Single submitter ⚠
- p.Arg500Gln Single submitter ⚠
- p.Arg500Trp Single submitter ⚠
- p.Arg55Cys Single submitter ⚠
- p.Arg6Trp Single submitter ⚠
- p.Arg76Gln Single submitter ⚠
- p.Arg78Gln Single submitter ⚠
- p.Arg95Trp Single submitter ⚠
- p.Asn106Lys Single submitter ⚠
- p.Asn265Asp Single submitter ⚠
- p.Asn94Ser Single submitter
- p.Asp206Asn Single submitter ⚠
- p.Gln317Lys Single submitter ⚠
- p.Glu188Lys Single submitter ⚠
- p.Glu29Lys Single submitter ⚠
- p.Glu310Asp Single submitter ⚠
- p.Glu320Asp Single submitter ⚠
- p.Glu62Lys Single submitter
- p.Gly136Arg Single submitter ⚠
- p.Gly436Arg Single submitter ⚠
- p.Gly523Ala Single submitter ⚠
- p.Gly567Arg Single submitter ⚠
- p.Ile160Thr Single submitter ⚠
- p.Ile160Val Single submitter ⚠
- p.Ile244Val Single submitter ⚠
- p.Ile249Leu Single submitter ⚠
- p.Ile9Thr Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Leu344Pro Single submitter ⚠
- p.Leu364Arg Single submitter
- p.Lys180Thr Single submitter ⚠
- p.Lys185Arg Single submitter ⚠
- p.Lys213Arg Single submitter ⚠
- p.Met117Thr Single submitter ⚠
- p.Met117Val Single submitter ⚠
- p.Met438Thr Single submitter ⚠
- p.Met84Ile Single submitter ⚠
- p.Met84Thr Single submitter ⚠
- p.Met88Ile Single submitter ⚠
- p.Phe463Ile Single submitter ⚠
- p.Phe556Leu Single submitter ⚠
- p.Pro13Ser Single submitter ⚠
- p.Pro232Ala Single submitter ⚠
- p.Pro329Leu Single submitter ⚠
- p.Pro40Ser Single submitter ⚠
- p.Pro419Ala Single submitter
- p.Pro470Leu Single submitter ⚠
- p.Ser135Phe Single submitter ⚠
- p.Ser179Pro Single submitter ⚠
- p.Ser42Leu Single submitter ⚠
- p.Ser460Leu Single submitter ⚠
- p.Ser477Leu Single submitter ⚠
- p.Ser559Leu Single submitter ⚠
- p.Thr361Ser Single submitter ⚠
- p.Thr396Ile Single submitter ⚠
- p.Tyr132Cys Single submitter ⚠
- p.Tyr259Cys Single submitter ⚠
- p.Tyr43Cys Single submitter ⚠
- p.Val154Leu Single submitter ⚠
- p.Val382Ile Single submitter ⚠
- p.Val544Ala Single submitter ⚠