Sugi Variant

Sugi Variant/TET3

TET3 — 547 ClinVar variants

All ClinVar germline TET3 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 337 flagged for review →

13 Pathogenic · 7 Pathogenic/Likely pathogenic · 38 Likely pathogenic · 18 Conflicting · 14 Benign · 4 Benign/Likely benign · 95 Likely benign · 358 Uncertain significance

Full TET3 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 337

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 1

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 11

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predicted LoF vs a conflicting call 2

ClinVar submitters conflict, and it's a predicted loss-of-function change in a gene where LoF causes disease — flagged for review, not resolved (verify NMD-escape for C-terminal truncations). Non-missense.

Predictors lean, ClinVar uncertain 254

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 254

Predictors split 69

The independent predictors disagree with each other — read with care.

All TET3 variants

Pathogenic 13

Pathogenic/Likely pathogenic 7

Likely pathogenic 38

Conflicting classifications of pathogenicity 18

Benign 14

Benign/Likely benign 4

Likely benign 95

Uncertain significance 358

Showing the top 300 by review status; the full set is in the sitemap.