TEX14 — 289 ClinVar variants

All ClinVar germline TEX14 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 206 flagged for review →

7 Pathogenic · 6 Likely pathogenic · 4 Conflicting · 14 Benign · 1 Benign/Likely benign · 47 Likely benign · 210 Uncertain significance

Full TEX14 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 206

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

TEX14 p.Arg768His Conflicting Single submitter
TEX14 p.Gln237Glu Conflicting Single submitter
spermatogenic failure 23

Predictors lean, ClinVar uncertain 180

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification. · showing the 150 best-reviewed of 180

Predictors split 24

The independent predictors disagree with each other — read with care.

All TEX14 variants

Pathogenic 7

p.Cys1183Ter Single submitter Non-obstructive azoospermia
p.Gln982Ter Single submitter Non-obstructive azoospermia
p.Pro1161fs Single submitter Non-obstructive azoospermia
p.Ser1209fs Single submitter Non-obstructive azoospermia
p.Tyr1056Ter Single submitter Non-obstructive azoospermia
p.Arg85Leu No assertion criteria spermatogenic failure 23 ⚠
p.Ser884fs No assertion criteria spermatogenic failure 23

Likely pathogenic 6

c.4267+1G>A Single submitter Male infertility with azoospermia or oligozoospermia due to single gene mutation
p.Ala461fs Single submitter spermatogenic failure 23
p.Arg1218Ter Single submitter spermatogenic failure 23
p.Leu497Pro Single submitter Non-obstructive azoospermia
p.Trp981Ter Single submitter spermatogenic failure 23
p.Tyr300Ter Single submitter spermatogenic failure 23

Conflicting classifications of pathogenicity 4

c.3818-1G>A Single submitter spermatogenic failure 23
p.Arg335Ter Single submitter spermatogenic failure 23
p.Arg768His Single submitter ⚠
p.Gln237Glu Single submitter spermatogenic failure 23 ⚠

Benign 14

c.2789-7T>C Multiple submitters
p.Thr979= Multiple submitters
p.Ala283= Single submitter
p.Arg136Cys Single submitter
p.His896= Single submitter
p.Leu1019= Single submitter
p.Val462Leu Single submitter
c.3172-1926G>A No assertion criteria TEX14-related disorder
c.637-11C>A No assertion criteria TEX14-related disorder
p.Asn1321= No assertion criteria TEX14-related disorder
p.Asn780Asp No assertion criteria TEX14-related disorder
p.Glu1409= No assertion criteria TEX14-related disorder
p.Leu313= No assertion criteria TEX14-related disorder
p.Lys1391= No assertion criteria TEX14-related disorder

Benign/Likely benign 1

p.Leu1380Phe Multiple submitters

Likely benign 47

c.3717+7A>G Multiple submitters
c.2703-19A>G Single submitter
c.3172-1907G>A Single submitter
c.3172-1990A>G Single submitter
c.3718-8C>T Single submitter
c.637-34C>G Single submitter
c.881+15C>T Single submitter
p.Ala218Val Single submitter
p.Ala461Thr Single submitter
p.Arg1018Gly Single submitter
p.Arg1099Lys Single submitter
p.Arg501Gln Single submitter
p.Arg516Lys Single submitter
p.Arg6His Single submitter
p.Asn1006Ser Single submitter
p.Asn535Ser Single submitter
p.Glu396Lys Single submitter
p.Glu990Lys Single submitter
p.Ile1213Thr Single submitter
p.Ile367= Single submitter
p.Ile379Val Single submitter
p.Leu1136= Single submitter
p.Leu269= Single submitter
p.Leu393= Single submitter
p.Leu630= Single submitter
p.Met144Leu Single submitter
p.Met559Thr Single submitter
p.Pro228Leu Single submitter
p.Pro808Leu Single submitter
p.Pro825Leu Single submitter
p.Ser395= Single submitter
p.Thr1003Met Single submitter
p.Thr1131= Single submitter
p.Thr721Met Single submitter
p.Thr816= Single submitter
p.Thr979Met Single submitter
p.Tyr537= Single submitter
p.Tyr537Cys Single submitter
p.Val1375Met Single submitter
c.1185-5C>T No assertion criteria TEX14-related disorder
c.2788+10_2788+11del No assertion criteria TEX14-related disorder
c.4158-10G>A No assertion criteria TEX14-related disorder
p.Ala417= No assertion criteria TEX14-related disorder
p.Asp119Asn No assertion criteria TEX14-related disorder
p.Ile740Val No assertion criteria TEX14-related disorder
p.Leu755= No assertion criteria TEX14-related disorder
p.Ser959= No assertion criteria TEX14-related disorder

Uncertain significance 210

p.Glu1351Gly Multiple submitters ⚠
c.2576+2T>G Single submitter spermatogenic failure 23
c.3172-1908C>T Single submitter prostate cancer ⚠
c.3172-1927G>A Single submitter ⚠
c.3172-1944A>C Single submitter ⚠
c.3172-1971C>G Single submitter ⚠
c.3172-1987C>G Single submitter ⚠
p.Ala1044Thr Single submitter ⚠
p.Ala1275Val Single submitter ⚠
p.Ala129Ser Single submitter ⚠
p.Ala1313Gly Single submitter ⚠
p.Ala238Thr Single submitter ⚠
p.Ala283Pro Single submitter
p.Ala384Val Single submitter ⚠
p.Ala417Thr Single submitter ⚠
p.Ala51Thr Single submitter ⚠
p.Ala63Val Single submitter ⚠
p.Ala642Gly Single submitter ⚠
p.Ala64Val Single submitter spermatogenic failure 23 ⚠
p.Ala939Val Single submitter ⚠
p.Ala967Thr Single submitter ⚠
p.Arg1031Lys Single submitter ⚠
p.Arg1268Ser Single submitter ⚠
p.Arg136His Single submitter ⚠
p.Arg1411Lys Single submitter ⚠
p.Arg193Gln Single submitter ⚠
p.Arg317Cys Single submitter ⚠
p.Arg322Cys Single submitter ⚠
p.Arg336Gln Single submitter ⚠
p.Arg336Trp Single submitter ⚠
p.Arg369Cys Single submitter ⚠
p.Arg406Gln Single submitter ⚠
p.Arg406Pro Single submitter ⚠
p.Arg516Thr Single submitter ⚠
p.Arg567Ser Single submitter ⚠
p.Arg6Cys Single submitter ⚠
p.Arg6Ser Single submitter ⚠
p.Arg768Cys Single submitter ⚠
p.Arg776Thr Single submitter ⚠
p.Arg85Cys Single submitter ⚠
p.Arg85His Single submitter ⚠
p.Asn1158Lys Single submitter ⚠
p.Asn415Ser Single submitter ⚠
p.Asn496Lys Single submitter ⚠
p.Asn83His Single submitter Non-obstructive azoospermia ⚠
p.Asp1135Asn Single submitter ⚠
p.Asp1135Tyr Single submitter ⚠
p.Asp1379Asn Single submitter ⚠
p.Asp1392Asn Single submitter ⚠
p.Asp1448Val Single submitter ⚠
p.Asp284Asn Single submitter ⚠
p.Asp403Gly Single submitter ⚠
p.Asp480Val Single submitter
p.Asp665Asn Single submitter ⚠
p.Asp809His Single submitter ⚠
p.Asp81His Single submitter ⚠
p.Asp966Asn Single submitter ⚠
p.Cys1257Tyr Single submitter ⚠
p.Gln1075His Single submitter ⚠
p.Gln1369Pro Single submitter Non-obstructive azoospermia ⚠
p.Gln139Arg Single submitter ⚠
p.Gln139Glu Single submitter ⚠
p.Gln145Leu Single submitter ⚠
p.Gln424Arg Single submitter ⚠
p.Gln424Glu Single submitter ⚠
p.Gln441Arg Single submitter ⚠
p.Gln490Arg Single submitter ⚠
p.Gln490Glu Single submitter ⚠
p.Gln518Arg Single submitter ⚠
p.Gln526Arg Single submitter ⚠
p.Gln738Arg Single submitter ⚠
p.Gln762Arg Single submitter ⚠
p.Gln840Pro Single submitter ⚠
p.Gln843Glu Single submitter ⚠
p.Gln860Leu Single submitter ⚠
p.Glu1142Gln Single submitter ⚠
p.Glu1362Lys Single submitter ⚠
p.Glu1387Lys Single submitter Non-obstructive azoospermia ⚠
p.Glu142Lys Single submitter ⚠
p.Glu234Lys Single submitter ⚠
p.Glu289Lys Single submitter ⚠
p.Glu291Lys Single submitter
p.Glu29Asp Single submitter ⚠
p.Glu314Lys Single submitter ⚠
p.Glu555Lys Single submitter ⚠
p.Glu624Lys Single submitter ⚠
p.Glu647Lys Single submitter ⚠
p.Glu687Ala Single submitter ⚠
p.Glu960Lys Single submitter ⚠
p.Gly1238Val Single submitter ⚠
p.Gly1303Cys Single submitter ⚠
p.Gly1316Arg Single submitter ⚠
p.Gly1434Val Single submitter ⚠
p.Gly399Val Single submitter ⚠
p.Gly455Ser Single submitter ⚠
p.Gly513Val Single submitter ⚠
p.Gly56Asp Single submitter ⚠
p.Gly56Cys Single submitter ⚠
p.Gly613Ser Single submitter ⚠
p.Gly789Asp Single submitter ⚠
p.Gly789Ser Single submitter ⚠
p.Gly79Arg Single submitter ⚠
p.Gly804Arg Single submitter ⚠
p.Gly805Asp Single submitter ⚠
p.Gly805Cys Single submitter ⚠
p.Gly998Ser Single submitter ⚠
p.His1159Tyr Single submitter ⚠
p.His298Tyr Single submitter ⚠
p.His349Arg Single submitter ⚠
p.His988Tyr Single submitter ⚠
p.Ile104Asn Single submitter ⚠
p.Ile1281Thr Single submitter ⚠
p.Ile1442Val Single submitter ⚠
p.Ile200Phe Single submitter ⚠
p.Ile200Val Single submitter ⚠
p.Ile205Met Single submitter ⚠
p.Ile205Val Single submitter ⚠
p.Ile230Thr Single submitter ⚠
p.Ile325Met Single submitter ⚠
p.Ile367Ser Single submitter ⚠
p.Ile433Thr Single submitter ⚠
p.Ile439Thr Single submitter ⚠
p.Ile448Thr Single submitter ⚠
p.Ile727Phe Single submitter ⚠
p.Leu1097Phe Single submitter ⚠
p.Leu1222Pro Single submitter ⚠
p.Leu1360Val Single submitter ⚠
p.Leu1417Val Single submitter ⚠
p.Leu224Val Single submitter ⚠
p.Leu269Arg Single submitter ⚠
p.Leu361Arg Single submitter ⚠
p.Leu556Pro Single submitter ⚠
p.Leu617Ile Single submitter ⚠
p.Leu630Ser Single submitter ⚠
p.Leu748Val Single submitter ⚠
p.Lys1126Arg Single submitter ⚠
p.Lys1156Arg Single submitter ⚠
p.Lys1156Thr Single submitter ⚠
p.Lys1220Arg Single submitter ⚠
p.Lys196Glu Single submitter ⚠
p.Lys315Asn Single submitter ⚠
p.Lys315Glu Single submitter ⚠
p.Lys425Arg Single submitter ⚠
p.Lys871Ile Single submitter ⚠
p.Met344Val Single submitter ⚠
p.Met392Leu Single submitter ⚠
p.Met392Val Single submitter ⚠
p.Met438Val Single submitter ⚠
p.Met495Ile Single submitter
p.Met551Val Single submitter ⚠
p.Met603Ile Single submitter ⚠
p.Met660Thr Single submitter ⚠
p.Met660Val Single submitter ⚠
p.Met667Thr Single submitter ⚠
p.Met930Lys Single submitter ⚠
p.Phe1102Cys Single submitter ⚠
p.Phe143Ile Single submitter ⚠
p.Phe213Leu Single submitter ⚠
p.Phe363Leu Single submitter ⚠
p.Phe366Cys Single submitter
p.Phe366Leu Single submitter ⚠
p.Pro1232Arg Single submitter ⚠
p.Pro1233Leu Single submitter ⚠
p.Pro1233Ser Single submitter ⚠
p.Pro1271Ser Single submitter ⚠
p.Pro449Leu Single submitter ⚠
p.Pro519Leu Single submitter ⚠
p.Pro601Leu Single submitter ⚠
p.Pro639Ser Single submitter ⚠
p.Pro808Thr Single submitter ⚠
p.Pro821Arg Single submitter ⚠
p.Pro893Arg Single submitter spermatogenic failure 23 ⚠
p.Pro951Leu Single submitter ⚠
p.Pro965Ala Single submitter ⚠
p.Pro965Thr Single submitter ⚠
p.Ser1060Arg Single submitter ⚠
p.Ser1138Asn Single submitter ⚠
p.Ser1151Thr Single submitter ⚠
p.Ser1209Cys Single submitter ⚠
p.Ser1259Leu Single submitter ⚠
p.Ser1420Ala Single submitter ⚠
p.Ser2Tyr Single submitter ⚠
p.Ser355Pro Single submitter ⚠
p.Ser435Gly Single submitter
p.Ser608Asn Single submitter ⚠
p.Ser619Gly Single submitter ⚠
p.Ser676Arg Single submitter ⚠
p.Ser689Pro Single submitter ⚠
p.Ser770Pro Single submitter ⚠
p.Ser852Gly Single submitter ⚠
p.Ser858Asn Single submitter ⚠
p.Ser890Phe Single submitter ⚠
p.Thr1131Met Single submitter ⚠
p.Thr1188Ile Single submitter ⚠
p.Thr216Ser Single submitter ⚠
p.Thr219Ile Single submitter ⚠
p.Thr411Ala Single submitter ⚠
p.Thr411Met Single submitter ⚠
p.Thr512Ala Single submitter ⚠
p.Thr520Pro Single submitter ⚠
p.Thr541Ile Single submitter ⚠
p.Thr779Arg Single submitter ⚠
p.Thr816Ile Single submitter ⚠
p.Thr867Ile Single submitter ⚠
p.Thr945Ile Single submitter ⚠
p.Trp693Arg Single submitter ⚠
p.Tyr1141Cys Single submitter ⚠
p.Tyr374Cys Single submitter ⚠
p.Tyr795Cys Single submitter ⚠
p.Val1052Ala Single submitter ⚠