Sugi Variant

Sugi Variant/TF

TF — 480 ClinVar variants

All ClinVar germline TF variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 95 flagged for review →

5 Pathogenic · 12 Likely pathogenic · 11 Conflicting · 20 Benign · 10 Benign/Likely benign · 316 Likely benign · 106 Uncertain significance

Full TF gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions

⚑ Evidence disagreements 95

Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.

Predictors vs ClinVar 2

ClinVar calls these pathogenic, but the computational predictors lean tolerated — the highest-value review flag.

Predictors agree, ClinVar conflicts 2

ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.

Predictors lean, ClinVar uncertain 71

ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.

Predictors split 20

The independent predictors disagree with each other — read with care.

All TF variants

Pathogenic 5

Likely pathogenic 12

Conflicting classifications of pathogenicity 11

Benign 20

Benign/Likely benign 10

Likely benign 316

Showing the top 300 by review status; the full set is in the sitemap.

Uncertain significance 106