TFB2M — 64 ClinVar variants
All ClinVar germline TFB2M variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 46 flagged for review →
2 Benign · 15 Likely benign · 47 Uncertain significance
Full TFB2M gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 46
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 41
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TFB2M p.Ala112Ser Uncertain significance Single submitter
- TFB2M p.Ala112Thr Uncertain significance Single submitter
- TFB2M p.Ala347Gly Uncertain significance Single submitter
- TFB2M p.Ala67Asp Uncertain significance Single submitter
- TFB2M p.Ala85Ser Uncertain significance Single submitter
- TFB2M p.Arg170Gly Uncertain significance Single submitter
- TFB2M p.Arg170Leu Uncertain significance Single submitter
- TFB2M p.Arg304His Uncertain significance Single submitter
- TFB2M p.Arg340Cys Uncertain significance Single submitter
- TFB2M p.Arg396Thr Uncertain significance Single submitter
- TFB2M p.Arg73His Uncertain significance Single submitter
- TFB2M p.Asn364Lys Uncertain significance Single submitter
- TFB2M p.Asp346Asn Uncertain significance Single submitter
- TFB2M p.Gln293Pro Uncertain significance Single submitter
- TFB2M p.Gly90Arg Uncertain significance Single submitter
- TFB2M p.His148Arg Uncertain significance Single submitter
- TFB2M p.Ile217Met Uncertain significance Single submitter
- TFB2M p.Ile273Thr Uncertain significance Single submitter
- TFB2M p.Ile336Val Uncertain significance Single submitter
- TFB2M p.Ile350Met Uncertain significance Single submitter
- TFB2M p.Ile87Val Uncertain significance Single submitter
- TFB2M p.Leu246Trp Uncertain significance Single submitter
- TFB2M p.Leu98Pro Uncertain significance Single submitter
- TFB2M p.Lys232Glu Uncertain significance Single submitter
- TFB2M p.Lys277Thr Uncertain significance Single submitter
- TFB2M p.Lys386Arg Uncertain significance Single submitter
- TFB2M p.Met227Thr Uncertain significance Single submitter
- TFB2M p.Pro106Leu Uncertain significance Single submitter
- TFB2M p.Pro164Ser Uncertain significance Single submitter
- TFB2M p.Pro182Arg Uncertain significance Single submitter
- TFB2M p.Pro188Leu Uncertain significance Single submitter
- TFB2M p.Pro241Arg Uncertain significance Single submitter
- TFB2M p.Pro244Ala Uncertain significance Single submitter
- TFB2M p.Pro267Ala Uncertain significance Single submitter
- TFB2M p.Ser197Asn Uncertain significance Single submitter
- TFB2M p.Ser93Ile Uncertain significance Single submitter
- TFB2M p.Thr128Ser Uncertain significance Single submitter
- TFB2M p.Thr275Asn Uncertain significance Single submitter
- TFB2M p.Thr334Ala Uncertain significance Single submitter
- TFB2M p.Tyr74Phe Uncertain significance Single submitter
- TFB2M p.Val121Phe Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TFB2M variants
Likely benign 15
- p.Ala64Thr Single submitter
- p.Ala85Val Single submitter
- p.Arg170Gln Single submitter
- p.Arg276Gln Single submitter
- p.Arg285His Single submitter
- p.Arg379Cys Single submitter
- p.Gln368Glu Single submitter
- p.Glu179Lys Single submitter
- p.Gly199Ser Single submitter
- p.Gly242Arg Single submitter
- p.Leu292Ile Single submitter
- p.Lys119Arg Single submitter
- p.Thr309Ala Single submitter ⚠
- p.Thr392= Single submitter
- p.Val75Ile Single submitter
Uncertain significance 47
- p.Ala112Ser Single submitter ⚠
- p.Ala112Thr Single submitter ⚠
- p.Ala347Gly Single submitter ⚠
- p.Ala67Asp Single submitter ⚠
- p.Ala85Ser Single submitter ⚠
- p.Arg170Gly Single submitter ⚠
- p.Arg170Leu Single submitter ⚠
- p.Arg304His Single submitter ⚠
- p.Arg331Cys Single submitter
- p.Arg331His Single submitter ⚠
- p.Arg340Cys Single submitter ⚠
- p.Arg396Thr Single submitter ⚠
- p.Arg73His Single submitter ⚠
- p.Asn364Lys Single submitter ⚠
- p.Asp346Asn Single submitter ⚠
- p.Asp369Tyr Single submitter ⚠
- p.Asp77Tyr Single submitter ⚠
- p.Gln293Pro Single submitter ⚠
- p.Gly90Arg Single submitter ⚠
- p.His148Arg Single submitter ⚠
- p.Ile217Met Single submitter ⚠
- p.Ile273Thr Single submitter ⚠
- p.Ile336Val Single submitter ⚠
- p.Ile350Met Single submitter ⚠
- p.Ile87Val Single submitter ⚠
- p.Leu246Trp Single submitter ⚠
- p.Leu98Pro Single submitter ⚠
- p.Lys232Glu Single submitter ⚠
- p.Lys277Thr Single submitter ⚠
- p.Lys386Arg Single submitter ⚠
- p.Met227Thr Single submitter ⚠
- p.Pro106Leu Single submitter ⚠
- p.Pro164Ser Single submitter ⚠
- p.Pro182Arg Single submitter ⚠
- p.Pro188Leu Single submitter ⚠
- p.Pro241Arg Single submitter ⚠
- p.Pro244Ala Single submitter ⚠
- p.Pro267Ala Single submitter ⚠
- p.Ser197Asn Single submitter ⚠
- p.Ser93Ile Single submitter ⚠
- p.Thr128Ser Single submitter ⚠
- p.Thr275Asn Single submitter ⚠
- p.Thr334Ala Single submitter ⚠
- p.Trp387Ter Single submitter
- p.Tyr218His Single submitter ⚠
- p.Tyr74Phe Single submitter ⚠
- p.Val121Phe Single submitter ⚠