TFDP2 — 40 ClinVar variants
All ClinVar germline TFDP2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 38 flagged for review →
40 Uncertain significance
Full TFDP2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 38
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 33
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TFDP2 p.Ala247Thr Uncertain significance Single submitter
- TFDP2 p.Arg121Gln Uncertain significance Single submitter
- TFDP2 p.Arg226Lys Uncertain significance Single submitter
- TFDP2 p.Arg317Trp Uncertain significance Single submitter
- TFDP2 p.Asn166Asp Uncertain significance Single submitter
- TFDP2 p.Asn29Ser Uncertain significance Single submitter
- TFDP2 p.Asn39Tyr Uncertain significance Single submitter
- TFDP2 p.Asn431Ser Uncertain significance Single submitter
- TFDP2 p.Asp432Glu Uncertain significance Single submitter
- TFDP2 p.Asp441Asn Uncertain significance Single submitter
- TFDP2 p.Gln369Arg Uncertain significance Single submitter
- TFDP2 p.Glu216Gln Uncertain significance Single submitter
- TFDP2 p.Glu307Val Uncertain significance Single submitter
- TFDP2 p.Ile112Met Uncertain significance Single submitter
- TFDP2 p.Ile46Val Uncertain significance Single submitter
- TFDP2 p.Ile54Leu Uncertain significance Single submitter
- TFDP2 p.Ile78Thr Uncertain significance Single submitter
- TFDP2 p.Leu268Pro Uncertain significance Single submitter
- TFDP2 p.Leu359Ser Uncertain significance Single submitter
- TFDP2 p.Leu393Phe Uncertain significance Single submitter
- TFDP2 p.Lys106Arg Uncertain significance Single submitter
- TFDP2 p.Lys123Gln Uncertain significance Single submitter
- TFDP2 p.Pro266Gln Uncertain significance Single submitter
- TFDP2 p.Pro383Arg Uncertain significance Single submitter
- TFDP2 p.Ser165Thr Uncertain significance Single submitter
- TFDP2 p.Ser173Leu Uncertain significance Single submitter
- TFDP2 p.Ser270Ala Uncertain significance Single submitter
- TFDP2 p.Ser80Gly Uncertain significance Single submitter
- TFDP2 p.Thr378Ala Uncertain significance Single submitter
- TFDP2 p.Thr40Ile Uncertain significance Single submitter
- TFDP2 p.Val252Ile Uncertain significance Single submitter
- TFDP2 p.Val387Ile Uncertain significance Single submitter
- TFDP2 p.Val58Ala Uncertain significance Single submitter
Predictors split 5
The independent predictors disagree with each other — read with care.
All TFDP2 variants
Uncertain significance 40
- c.520-3C>T Single submitter
- p.Ala247Thr Single submitter ⚠
- p.Arg121Gln Single submitter ⚠
- p.Arg226Lys Single submitter ⚠
- p.Arg317Gln Single submitter ⚠
- p.Arg317Trp Single submitter ⚠
- p.Asn166Asp Single submitter ⚠
- p.Asn29Ser Single submitter ⚠
- p.Asn39Tyr Single submitter ⚠
- p.Asn431Ser Single submitter ⚠
- p.Asp126Asn Single submitter ⚠
- p.Asp126Gly Single submitter ⚠
- p.Asp432Glu Single submitter ⚠
- p.Asp441Asn Single submitter ⚠
- p.Cys329Ser Single submitter
- p.Gln369Arg Single submitter ⚠
- p.Glu216Gln Single submitter ⚠
- p.Glu307Val Single submitter ⚠
- p.Gly347Val Single submitter ⚠
- p.Ile112Met Single submitter ⚠
- p.Ile46Val Single submitter ⚠
- p.Ile54Leu Single submitter ⚠
- p.Ile78Thr Single submitter ⚠
- p.Leu268Pro Single submitter ⚠
- p.Leu359Ser Single submitter ⚠
- p.Leu393Phe Single submitter ⚠
- p.Lys106Arg Single submitter ⚠
- p.Lys123Gln Single submitter ⚠
- p.Pro266Gln Single submitter ⚠
- p.Pro383Arg Single submitter ⚠
- p.Ser165Thr Single submitter ⚠
- p.Ser173Leu Single submitter ⚠
- p.Ser270Ala Single submitter ⚠
- p.Ser80Gly Single submitter ⚠
- p.Thr378Ala Single submitter ⚠
- p.Thr40Ile Single submitter ⚠
- p.Thr426Asn Single submitter ⚠
- p.Val252Ile Single submitter ⚠
- p.Val387Ile Single submitter ⚠
- p.Val58Ala Single submitter ⚠