TFIP11 — 79 ClinVar variants
All ClinVar germline TFIP11 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 75 flagged for review →
1 Benign/Likely benign · 2 Likely benign · 76 Uncertain significance
Full TFIP11 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 75
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 63
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TFIP11 p.Ala316Ser Uncertain significance Single submitter
- TFIP11 p.Ala316Thr Uncertain significance Single submitter
- TFIP11 p.Ala476Gly Uncertain significance Single submitter
- TFIP11 p.Arg13Cys Uncertain significance Single submitter
- TFIP11 p.Arg251Gly Uncertain significance Single submitter
- TFIP11 p.Arg346Gln Uncertain significance Single submitter
- TFIP11 p.Arg368Gln Uncertain significance Single submitter
- TFIP11 p.Arg402Cys Uncertain significance Single submitter
- TFIP11 p.Arg402His Uncertain significance Single submitter
- TFIP11 p.Arg420Cys Uncertain significance Single submitter
- TFIP11 p.Arg420Leu Uncertain significance Single submitter
- TFIP11 p.Arg571Cys Uncertain significance Single submitter
- TFIP11 p.Arg57Gln Uncertain significance Single submitter
- TFIP11 p.Arg728Gln Uncertain significance Single submitter
- TFIP11 p.Arg813Trp Uncertain significance Single submitter
- TFIP11 p.Asn351Ser Uncertain significance Single submitter
- TFIP11 p.Asn36Ser Uncertain significance Single submitter
- TFIP11 p.Asp28Gly Uncertain significance Single submitter
- TFIP11 p.Asp293Asn Uncertain significance Single submitter
- TFIP11 p.Asp339Glu Uncertain significance Single submitter
- TFIP11 p.Asp398Glu Uncertain significance Single submitter
- TFIP11 p.Asp444Asn Uncertain significance Single submitter
- TFIP11 p.Cys391Tyr Uncertain significance Single submitter
- TFIP11 p.Gln333Glu Uncertain significance Single submitter
- TFIP11 p.Gln343Arg Uncertain significance Single submitter
- TFIP11 p.Glu212Lys Uncertain significance Single submitter
- TFIP11 p.Glu213Asp Uncertain significance Single submitter
- TFIP11 p.Glu319Gln Uncertain significance Single submitter
- TFIP11 p.Glu319Lys Uncertain significance Single submitter
- TFIP11 p.Glu381Gly Uncertain significance Single submitter
- TFIP11 p.Glu438Lys Uncertain significance Single submitter
- TFIP11 p.Glu729Lys Uncertain significance Single submitter
- TFIP11 p.Gly307Cys Uncertain significance Single submitter
- TFIP11 p.Gly469Arg Uncertain significance Single submitter
- TFIP11 p.Gly763Ala Uncertain significance Single submitter
- TFIP11 p.His657Leu Uncertain significance Single submitter
- TFIP11 p.Ile14Leu Uncertain significance Single submitter
- TFIP11 p.Ile179Val Uncertain significance Single submitter
- TFIP11 p.Ile492Thr Uncertain significance Single submitter
- TFIP11 p.Ile612Thr Uncertain significance Single submitter
- TFIP11 p.Ile639Thr Uncertain significance Single submitter
- TFIP11 p.Ile645Val Uncertain significance Single submitter
- TFIP11 p.Leu407Pro Uncertain significance Single submitter
- TFIP11 p.Leu442Pro Uncertain significance Single submitter
- TFIP11 p.Lys534Asn Uncertain significance Single submitter
- TFIP11 p.Lys589Arg Uncertain significance Single submitter
- TFIP11 p.Lys656Glu Uncertain significance Single submitter
- TFIP11 p.Met748Leu Uncertain significance Single submitter
- TFIP11 p.Pro389Ser Uncertain significance Single submitter
- TFIP11 p.Pro503Leu Uncertain significance Single submitter
- TFIP11 p.Pro530Ser Uncertain significance Single submitter
- TFIP11 p.Ser195Cys Uncertain significance Single submitter
- TFIP11 p.Ser286Gly Uncertain significance Single submitter
- TFIP11 p.Ser371Leu Uncertain significance Single submitter
- TFIP11 p.Ser418Tyr Uncertain significance Single submitter
- TFIP11 p.Thr27Ile Uncertain significance Single submitter
- TFIP11 p.Thr449Ile Uncertain significance Single submitter
- TFIP11 p.Thr50Ile Uncertain significance Single submitter
- TFIP11 p.Thr737Met Uncertain significance Single submitter
- TFIP11 p.Trp482Arg Uncertain significance Single submitter
- TFIP11 p.Tyr429Cys Uncertain significance Single submitter
- TFIP11 p.Val624Ile Uncertain significance Single submitter
- TFIP11 p.Val764Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- TFIP11 p.Arg346Trp Uncertain significance Single submitter
- TFIP11 p.Arg385Trp Uncertain significance Single submitter
- TFIP11 p.Arg386Gln Uncertain significance Single submitter
- TFIP11 p.Arg420Pro Uncertain significance Single submitter
- TFIP11 p.Asn626Asp Uncertain significance Single submitter
- TFIP11 p.Glu399Lys Uncertain significance Single submitter
- TFIP11 p.Glu750Lys Uncertain significance Single submitter
- TFIP11 p.Glu783Asp Uncertain significance Single submitter
- TFIP11 p.Gly617Glu Uncertain significance Single submitter
- TFIP11 p.Leu734Phe Uncertain significance Single submitter
- TFIP11 p.Met632Val Uncertain significance Single submitter
- TFIP11 p.Phe205Leu Uncertain significance Single submitter
All TFIP11 variants
Benign/Likely benign 1
- p.Arg8Gln Multiple submitters
Likely benign 2
- p.Glu434Asp Single submitter
- p.Thr449= Single submitter
Uncertain significance 76
- p.Ala316Ser Single submitter ⚠
- p.Ala316Thr Single submitter ⚠
- p.Ala476Gly Single submitter ⚠
- p.Arg13Cys Single submitter ⚠
- p.Arg251Gly Single submitter ⚠
- p.Arg346Gln Single submitter ⚠
- p.Arg346Trp Single submitter ⚠
- p.Arg368Gln Single submitter ⚠
- p.Arg385Trp Single submitter ⚠
- p.Arg386Gln Single submitter ⚠
- p.Arg402Cys Single submitter ⚠
- p.Arg402His Single submitter ⚠
- p.Arg420Cys Single submitter ⚠
- p.Arg420Leu Single submitter ⚠
- p.Arg420Pro Single submitter ⚠
- p.Arg490Gln Single submitter
- p.Arg571Cys Single submitter ⚠
- p.Arg57Gln Single submitter ⚠
- p.Arg728Gln Single submitter ⚠
- p.Arg813Trp Single submitter ⚠
- p.Asn351Ser Single submitter ⚠
- p.Asn36Ser Single submitter ⚠
- p.Asn626Asp Single submitter ⚠
- p.Asp28Gly Single submitter ⚠
- p.Asp293Asn Single submitter ⚠
- p.Asp339Glu Single submitter ⚠
- p.Asp398Glu Single submitter ⚠
- p.Asp444Asn Single submitter ⚠
- p.Cys391Tyr Single submitter ⚠
- p.Gln333Glu Single submitter ⚠
- p.Gln343Arg Single submitter ⚠
- p.Glu212Lys Single submitter ⚠
- p.Glu213Asp Single submitter ⚠
- p.Glu319Gln Single submitter ⚠
- p.Glu319Lys Single submitter ⚠
- p.Glu381Gly Single submitter ⚠
- p.Glu399Lys Single submitter ⚠
- p.Glu438Lys Single submitter ⚠
- p.Glu729Lys Single submitter ⚠
- p.Glu750Lys Single submitter ⚠
- p.Glu783Asp Single submitter ⚠
- p.Gly307Cys Single submitter ⚠
- p.Gly469Arg Single submitter ⚠
- p.Gly617Glu Single submitter ⚠
- p.Gly763Ala Single submitter ⚠
- p.His657Leu Single submitter ⚠
- p.Ile14Leu Single submitter ⚠
- p.Ile179Val Single submitter ⚠
- p.Ile492Thr Single submitter ⚠
- p.Ile612Thr Single submitter ⚠
- p.Ile639Thr Single submitter ⚠
- p.Ile645Val Single submitter ⚠
- p.Leu407Pro Single submitter ⚠
- p.Leu442Pro Single submitter ⚠
- p.Leu734Phe Single submitter ⚠
- p.Lys534Asn Single submitter ⚠
- p.Lys589Arg Single submitter ⚠
- p.Lys656Glu Single submitter ⚠
- p.Met632Val Single submitter ⚠
- p.Met748Leu Single submitter ⚠
- p.Phe205Leu Single submitter ⚠
- p.Pro389Ser Single submitter ⚠
- p.Pro503Leu Single submitter ⚠
- p.Pro530Ser Single submitter ⚠
- p.Ser195Cys Single submitter ⚠
- p.Ser286Gly Single submitter ⚠
- p.Ser371Leu Single submitter ⚠
- p.Ser418Tyr Single submitter ⚠
- p.Thr27Ile Single submitter ⚠
- p.Thr449Ile Single submitter ⚠
- p.Thr50Ile Single submitter ⚠
- p.Thr737Met Single submitter ⚠
- p.Trp482Arg Single submitter ⚠
- p.Tyr429Cys Single submitter ⚠
- p.Val624Ile Single submitter ⚠
- p.Val764Ala Single submitter ⚠