TFPI2 — 40 ClinVar variants
All ClinVar germline TFPI2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 33 flagged for review →
1 Conflicting · 3 Benign · 4 Likely benign · 32 Uncertain significance
Full TFPI2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 33
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors agree, ClinVar conflicts 1
ClinVar submitters conflict, but the independent predictors unanimously agree — a QC review flag, not a reclassification.
Predictors lean, ClinVar uncertain 29
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TFPI2 p.Ala47Pro Uncertain significance Single submitter
- TFPI2 p.Ala73Thr Uncertain significance Single submitter
- TFPI2 p.Ala85Pro Uncertain significance Single submitter
- TFPI2 p.Arg138Met Uncertain significance Single submitter
- TFPI2 p.Arg206His Uncertain significance Single submitter
- TFPI2 p.Arg226Thr Uncertain significance Single submitter
- TFPI2 p.Arg228Gln Uncertain significance Single submitter
- TFPI2 p.Arg231Trp Uncertain significance Single submitter
- TFPI2 p.Asp23Asn Uncertain significance Single submitter
- TFPI2 p.Asp83Tyr Uncertain significance Single submitter
- TFPI2 p.Cys36Ser Uncertain significance Single submitter
- TFPI2 p.Glu90Lys Uncertain significance Single submitter
- TFPI2 p.Gly165Val Uncertain significance Single submitter
- TFPI2 p.Gly30Glu Uncertain significance Single submitter
- TFPI2 p.Ile135Thr Uncertain significance Single submitter
- TFPI2 p.Lys210Arg Uncertain significance Single submitter
- TFPI2 p.Phe64Leu Uncertain significance Single submitter
- TFPI2 p.Pro155Ser Uncertain significance Single submitter
- TFPI2 p.Pro219Leu Uncertain significance Single submitter
- TFPI2 p.Pro219Ser Uncertain significance Single submitter
- TFPI2 p.Pro6Arg Uncertain significance Single submitter
- TFPI2 p.Ser10Trp Uncertain significance Single submitter
- TFPI2 p.Ser118Thr Uncertain significance Single submitter
- TFPI2 p.Ser225Arg Uncertain significance Single submitter
- TFPI2 p.Ser60Gly Uncertain significance Single submitter
- TFPI2 p.Thr189Ala Uncertain significance Single submitter
- TFPI2 p.Thr78Ser Uncertain significance Single submitter
- TFPI2 p.Tyr113Phe Uncertain significance Single submitter
- TFPI2 p.Tyr66Cys Uncertain significance Single submitter
Predictors split 3
The independent predictors disagree with each other — read with care.
All TFPI2 variants
Conflicting classifications of pathogenicity 1
- p.Arg132Gln Single submitter ⚠
Benign 3
- c.271+8C>T Multiple submitters
- p.Arg228Trp Multiple submitters
- p.Arg88= Multiple submitters
Likely benign 4
- p.Arg222Leu Single submitter
- p.Leu48Arg Single submitter
- p.Ser10Leu Single submitter
- p.Ser225Asn Single submitter
Uncertain significance 32
- p.Ala47Pro Single submitter ⚠
- p.Ala73Thr Single submitter ⚠
- p.Ala85Pro Single submitter ⚠
- p.Arg138Met Single submitter ⚠
- p.Arg206Cys Single submitter ⚠
- p.Arg206His Single submitter ⚠
- p.Arg226Thr Single submitter ⚠
- p.Arg228Gln Single submitter ⚠
- p.Arg231Trp Single submitter ⚠
- p.Arg51His Single submitter ⚠
- p.Asp23Asn Single submitter ⚠
- p.Asp83Tyr Single submitter ⚠
- p.Cys36Ser Single submitter ⚠
- p.Glu90Lys Single submitter ⚠
- p.Gly165Val Single submitter ⚠
- p.Gly30Glu Single submitter ⚠
- p.Ile135Thr Single submitter ⚠
- p.Lys210Arg Single submitter ⚠
- p.Phe125Leu Single submitter ⚠
- p.Phe64Leu Single submitter ⚠
- p.Pro155Ser Single submitter ⚠
- p.Pro219Leu Single submitter ⚠
- p.Pro219Ser Single submitter ⚠
- p.Pro6Arg Single submitter ⚠
- p.Ser10Trp Single submitter ⚠
- p.Ser118Thr Single submitter ⚠
- p.Ser225Arg Single submitter ⚠
- p.Ser60Gly Single submitter ⚠
- p.Thr189Ala Single submitter ⚠
- p.Thr78Ser Single submitter ⚠
- p.Tyr113Phe Single submitter ⚠
- p.Tyr66Cys Single submitter ⚠