TGM2 — 127 ClinVar variants
All ClinVar germline TGM2 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 92 flagged for review →
15 Benign · 17 Likely benign · 95 Uncertain significance
Full TGM2 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 92
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 75
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- TGM2 p.Ala147Val Uncertain significance Single submitter
- TGM2 p.Ala172Val Uncertain significance Single submitter
- TGM2 p.Ala390Val Uncertain significance Single submitter
- TGM2 p.Ala500Thr Uncertain significance Single submitter
- TGM2 p.Ala578Thr Uncertain significance Single submitter
- TGM2 p.Ala71Thr Uncertain significance Single submitter
- TGM2 p.Arg116Leu Uncertain significance Single submitter
- TGM2 p.Arg19Gln Uncertain significance Single submitter
- TGM2 p.Arg209His Uncertain significance Single submitter
- TGM2 p.Arg262Gln Uncertain significance Single submitter
- TGM2 p.Arg263Cys Uncertain significance Single submitter
- TGM2 p.Arg271Cys Uncertain significance Single submitter
- TGM2 p.Arg271His Uncertain significance Single submitter
- TGM2 p.Arg28Gln Uncertain significance Single submitter
- TGM2 p.Arg296Cys Uncertain significance Single submitter
- TGM2 p.Arg506His Uncertain significance Single submitter
- TGM2 p.Arg512His Uncertain significance Single submitter
- TGM2 p.Arg592Gln Uncertain significance Single submitter
- TGM2 p.Arg76Cys Uncertain significance Single submitter
- TGM2 p.Asn417His Uncertain significance Single submitter
- TGM2 p.Asp232Gly Uncertain significance Single submitter
- TGM2 p.Asp25Asn Uncertain significance Single submitter
- TGM2 p.Asp358Val Uncertain significance Single submitter
- TGM2 p.Asp403Tyr Uncertain significance Single submitter
- TGM2 p.Asp640Gly Uncertain significance Single submitter
- TGM2 p.Cys98Phe Uncertain significance Single submitter
- TGM2 p.Gln103Leu Uncertain significance Single submitter
- TGM2 p.Gln599Leu Uncertain significance Single submitter
- TGM2 p.Gln69Leu Uncertain significance Single submitter
- TGM2 p.Glu549Ala Uncertain significance Single submitter
- TGM2 p.Glu631Gln Uncertain significance Single submitter
- TGM2 p.Glu637Val Uncertain significance Single submitter
- TGM2 p.Glu643Lys Uncertain significance Single submitter
- TGM2 p.Glu669Lys Uncertain significance Single submitter
- TGM2 p.Gly124Asp Uncertain significance Single submitter
- TGM2 p.Gly133Val Uncertain significance Single submitter
- TGM2 p.Gly208Ser Uncertain significance Single submitter
- TGM2 p.Gly268Ser Uncertain significance Single submitter
- TGM2 p.Gly47Asp Uncertain significance Single submitter
- TGM2 p.Gly525Ala Uncertain significance Single submitter
- TGM2 p.Gly619Asp Uncertain significance Single submitter
- TGM2 p.Gly626Ala Uncertain significance Single submitter
- TGM2 p.His22Arg Uncertain significance Single submitter
- TGM2 p.Ile546Val Uncertain significance Single submitter
- TGM2 p.Ile589Thr Uncertain significance Single submitter
- TGM2 p.Leu311His Uncertain significance Single submitter
- TGM2 p.Lys550Asn Uncertain significance Single submitter
- TGM2 p.Lys550Gln Uncertain significance Single submitter
- TGM2 p.Lys550Thr Uncertain significance Single submitter
- TGM2 p.Lys649Arg Uncertain significance Single submitter
- TGM2 p.Phe537Leu Uncertain significance Single submitter
- TGM2 p.Pro144Arg Uncertain significance Single submitter
- TGM2 p.Pro349Leu Uncertain significance Single submitter
- TGM2 p.Pro543Ser Uncertain significance Single submitter
- TGM2 p.Pro570Leu Uncertain significance Single submitter
- TGM2 p.Pro570Ser Uncertain significance Single submitter
- TGM2 p.Pro587Ser Uncertain significance Single submitter
- TGM2 p.Pro639Ser Uncertain significance Single submitter
- TGM2 p.Ser101Leu Uncertain significance Single submitter
- TGM2 p.Ser129Asn Uncertain significance Single submitter
- TGM2 p.Ser303Leu Uncertain significance Single submitter
- TGM2 p.Ser328Arg Uncertain significance Single submitter
- TGM2 p.Ser385Gly Uncertain significance Single submitter
- TGM2 p.Ser53Asn Uncertain significance Single submitter
- TGM2 p.Thr496Asn Uncertain significance Single submitter
- TGM2 p.Thr91Ile Uncertain significance Single submitter
- TGM2 p.Trp40Cys Uncertain significance Single submitter
- TGM2 p.Tyr388Asn Uncertain significance Single submitter
- TGM2 p.Tyr548Cys Uncertain significance Single submitter
- TGM2 p.Val160Ile Uncertain significance Single submitter
- TGM2 p.Val298Met Uncertain significance Single submitter
- TGM2 p.Val491Ile Uncertain significance Single submitter
- TGM2 p.Val636Leu Uncertain significance Single submitter
- TGM2 p.Val665Leu Uncertain significance Single submitter
- TGM2 p.Val92Met Uncertain significance Single submitter
Predictors split 17
The independent predictors disagree with each other — read with care.
- TGM2 p.Arg377His Benign Multiple submitters
- TGM2 p.Ala110Thr Likely benign Single submitter
- TGM2 p.Ala459Val Uncertain significance Single submitter
- TGM2 p.Arg156Gln Uncertain significance Single submitter
- TGM2 p.Arg240His Uncertain significance Single submitter
- TGM2 p.Arg48His Uncertain significance Single submitter
- TGM2 p.Asp400His Uncertain significance Single submitter
- TGM2 p.Glu329Lys Uncertain significance Single submitter
- TGM2 p.Ile379Leu Uncertain significance Single submitter
- TGM2 p.Leu100Phe Uncertain significance Single submitter
- TGM2 p.Leu529Pro Uncertain significance Single submitter
- TGM2 p.Leu544Phe Uncertain significance Single submitter
- TGM2 p.Pro345Leu Uncertain significance Single submitter
- TGM2 p.Pro359Ser Uncertain significance Single submitter
- TGM2 p.Pro597Leu Uncertain significance Single submitter
- TGM2 p.Thr106Ile Uncertain significance Single submitter
- TGM2 p.Tyr548Ser Uncertain significance Single submitter
All TGM2 variants
Benign 15
- p.Ala282= Multiple submitters
- p.Ala390= Multiple submitters
- p.Arg28= Multiple submitters
- p.Arg377His Multiple submitters ⚠
- p.Arg76His Multiple submitters
- p.Asp326= Multiple submitters
- p.Ile416= Multiple submitters
- p.Pro217= Multiple submitters
- p.Pro641= Multiple submitters
- p.Thr635= Multiple submitters
- p.Val542Phe Multiple submitters
- p.Ala145= Single submitter
- p.Ala71= Single submitter
- p.Glu314= Single submitter
- p.Tyr245= Single submitter
Likely benign 17
- c.433+3G>A Multiple submitters
- p.Thr368= Multiple submitters
- p.Ala110Thr Single submitter ⚠
- p.Ala207= Single submitter
- p.Arg296= Single submitter
- p.Arg34= Single submitter
- p.Arg418His Single submitter
- p.Asp434= Single submitter
- p.Gly248= Single submitter
- p.His305= Single submitter
- p.Leu347= Single submitter
- p.Pro345= Single submitter
- p.Pro656= Single submitter
- p.Pro686= Single submitter
- p.Ser101= Single submitter
- p.Ser449= Single submitter
- p.Thr513= Single submitter
Uncertain significance 95
- p.Ala147Val Single submitter ⚠
- p.Ala172Val Single submitter ⚠
- p.Ala390Val Single submitter ⚠
- p.Ala459Val Single submitter ⚠
- p.Ala500Thr Single submitter ⚠
- p.Ala511Val Single submitter
- p.Ala578Thr Single submitter ⚠
- p.Ala71Thr Single submitter ⚠
- p.Arg116Leu Single submitter ⚠
- p.Arg156Gln Single submitter ⚠
- p.Arg19Gln Single submitter ⚠
- p.Arg209His Single submitter ⚠
- p.Arg240His Single submitter ⚠
- p.Arg262Gln Single submitter ⚠
- p.Arg263Cys Single submitter ⚠
- p.Arg271Cys Single submitter ⚠
- p.Arg271His Single submitter ⚠
- p.Arg28Gln Single submitter ⚠
- p.Arg296Cys Single submitter ⚠
- p.Arg48Cys Single submitter
- p.Arg48His Single submitter ⚠
- p.Arg506His Single submitter ⚠
- p.Arg512His Single submitter ⚠
- p.Arg592Gln Single submitter ⚠
- p.Arg592Leu Single submitter
- p.Arg76Cys Single submitter ⚠
- p.Asn417His Single submitter ⚠
- p.Asp232Gly Single submitter ⚠
- p.Asp25Asn Single submitter ⚠
- p.Asp358Val Single submitter ⚠
- p.Asp400His Single submitter ⚠
- p.Asp403Tyr Single submitter ⚠
- p.Asp640Gly Single submitter ⚠
- p.Cys98Phe Single submitter ⚠
- p.Gln103Leu Single submitter ⚠
- p.Gln599Leu Single submitter ⚠
- p.Gln69Leu Single submitter ⚠
- p.Glu329Lys Single submitter ⚠
- p.Glu549Ala Single submitter ⚠
- p.Glu631Gln Single submitter ⚠
- p.Glu637Val Single submitter ⚠
- p.Glu643Lys Single submitter ⚠
- p.Glu669Lys Single submitter ⚠
- p.Gly124Asp Single submitter ⚠
- p.Gly133Val Single submitter ⚠
- p.Gly208Ser Single submitter ⚠
- p.Gly268Ser Single submitter ⚠
- p.Gly47Asp Single submitter ⚠
- p.Gly525Ala Single submitter ⚠
- p.Gly619Asp Single submitter ⚠
- p.Gly626Ala Single submitter ⚠
- p.His22Arg Single submitter ⚠
- p.Ile379Leu Single submitter ⚠
- p.Ile546Val Single submitter ⚠
- p.Ile589Thr Single submitter ⚠
- p.Leu100Phe Single submitter ⚠
- p.Leu311His Single submitter ⚠
- p.Leu529Pro Single submitter ⚠
- p.Leu544Phe Single submitter ⚠
- p.Lys550Asn Single submitter ⚠
- p.Lys550Gln Single submitter ⚠
- p.Lys550Thr Single submitter ⚠
- p.Lys649Arg Single submitter ⚠
- p.Phe537Leu Single submitter ⚠
- p.Pro144Arg Single submitter ⚠
- p.Pro345Leu Single submitter ⚠
- p.Pro349Leu Single submitter ⚠
- p.Pro359Ser Single submitter ⚠
- p.Pro543Ser Single submitter ⚠
- p.Pro570Leu Single submitter ⚠
- p.Pro570Ser Single submitter ⚠
- p.Pro587Ser Single submitter ⚠
- p.Pro597Leu Single submitter ⚠
- p.Pro639Ser Single submitter ⚠
- p.Ser101Leu Single submitter ⚠
- p.Ser129Asn Single submitter ⚠
- p.Ser303Leu Single submitter ⚠
- p.Ser328Arg Single submitter ⚠
- p.Ser385Gly Single submitter ⚠
- p.Ser53Asn Single submitter ⚠
- p.Thr106Ile Single submitter ⚠
- p.Thr496Asn Single submitter ⚠
- p.Thr91Ile Single submitter ⚠
- p.Trp40Cys Single submitter ⚠
- p.Tyr388Asn Single submitter ⚠
- p.Tyr548Cys Single submitter ⚠
- p.Tyr548Ser Single submitter ⚠
- p.Val160Ile Single submitter ⚠
- p.Val298Met Single submitter ⚠
- p.Val401Met Single submitter
- p.Val491Ile Single submitter ⚠
- p.Val636Leu Single submitter ⚠
- p.Val665Leu Single submitter ⚠
- p.Val666Ala Single submitter
- p.Val92Met Single submitter ⚠