THEM6 — 33 ClinVar variants
All ClinVar germline THEM6 variants across every classification, each assembled from ClinVar, gnomAD, AlphaMissense, conservation and more. 32 flagged for review →
33 Uncertain significance
Full THEM6 gene report on Sugi Atlas → Gene function, pathways, protein structure, constraint & interactions⚑ Evidence disagreements 32
Variants where the independent computational evidence doesn't line up with the clinical picture — a QC signal for a second look, not a reclassification.
Predictors lean, ClinVar uncertain 20
ClinVar classifies these uncertain (VUS), but the independent predictors unanimously lean one way — a triage signal for review, not a reclassification.
- THEM6 p.Ala30Thr Uncertain significance Single submitter
- THEM6 p.Arg112His Uncertain significance Single submitter
- THEM6 p.Arg120Leu Uncertain significance Single submitter
- THEM6 p.Arg42Pro Uncertain significance Single submitter
- THEM6 p.Arg72Cys Uncertain significance Single submitter
- THEM6 p.Asp60Glu Uncertain significance Single submitter
- THEM6 p.Gln193Arg Uncertain significance Single submitter
- THEM6 p.Glu93Gln Uncertain significance Single submitter
- THEM6 p.Gly86Trp Uncertain significance Single submitter
- THEM6 p.Ile185Met Uncertain significance Single submitter
- THEM6 p.Leu111Val Uncertain significance Single submitter
- THEM6 p.Leu114Val Uncertain significance Single submitter
- THEM6 p.Leu61Pro Uncertain significance Single submitter
- THEM6 p.Met197Val Uncertain significance Single submitter
- THEM6 p.Pro51Ser Uncertain significance Single submitter
- THEM6 p.Ser103Thr Uncertain significance Single submitter
- THEM6 p.Ser57Thr Uncertain significance Single submitter
- THEM6 p.Thr121Ser Uncertain significance Single submitter
- THEM6 p.Val204Ile Uncertain significance Single submitter
- THEM6 p.Val25Ala Uncertain significance Single submitter
Predictors split 12
The independent predictors disagree with each other — read with care.
- THEM6 p.Ala102Thr Uncertain significance Single submitter
- THEM6 p.Arg122His Uncertain significance Single submitter
- THEM6 p.Arg136Cys Uncertain significance Single submitter
- THEM6 p.Arg53His Uncertain significance Single submitter
- THEM6 p.Asn66Thr Uncertain significance Single submitter
- THEM6 p.Glu189Lys Uncertain significance Single submitter
- THEM6 p.His107Arg Uncertain significance Single submitter
- THEM6 p.His97Pro Uncertain significance Single submitter
- THEM6 p.Leu111Arg Uncertain significance Single submitter
- THEM6 p.Leu32Met Uncertain significance Single submitter
- THEM6 p.Phe117Leu Uncertain significance Single submitter
- THEM6 p.Ser110Leu Uncertain significance Single submitter
All THEM6 variants
Uncertain significance 33
- p.Ala102Thr Single submitter ⚠
- p.Ala30Thr Single submitter ⚠
- p.Arg112His Single submitter ⚠
- p.Arg120Leu Single submitter ⚠
- p.Arg122His Single submitter ⚠
- p.Arg136Cys Single submitter ⚠
- p.Arg42Pro Single submitter ⚠
- p.Arg53His Single submitter ⚠
- p.Arg72Cys Single submitter ⚠
- p.Asn66Thr Single submitter ⚠
- p.Asp60Glu Single submitter ⚠
- p.Gln193Arg Single submitter ⚠
- p.Glu189Lys Single submitter ⚠
- p.Glu93Gln Single submitter ⚠
- p.Gly86Trp Single submitter ⚠
- p.His107Arg Single submitter ⚠
- p.His97Pro Single submitter ⚠
- p.Ile185Met Single submitter ⚠
- p.Leu111Arg Single submitter ⚠
- p.Leu111Val Single submitter ⚠
- p.Leu114Val Single submitter ⚠
- p.Leu32Met Single submitter ⚠
- p.Leu61Pro Single submitter ⚠
- p.Met197Val Single submitter ⚠
- p.Phe117Leu Single submitter ⚠
- p.Pro51Ser Single submitter ⚠
- p.Ser103Thr Single submitter ⚠
- p.Ser110Leu Single submitter ⚠
- p.Ser57Thr Single submitter ⚠
- p.Thr121Ser Single submitter ⚠
- p.Val204Ile Single submitter ⚠
- p.Val25Ala Single submitter ⚠
- p.Val99Met Single submitter